| NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. | NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C., Free PMC Article | 08/5/2024 |
| The Effect of Inactivating Heterozygous Mutation in NBS1 Gene on DNA Damage and Repair Markers and Apoptosis Markers in Mice. | The Effect of Inactivating Heterozygous Mutation in NBS1 Gene on DNA Damage and Repair Markers and Apoptosis Markers in Mice.
Yurova MN, Golubev AG, Aleksakhina SN, Fedoros EI, Tumanyan IA, Otradnova EA, Soloviev IV, Sergiev PV, Imyanitov EN. | 09/8/2023 |
| Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas. | Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas.
Reuss DE, Downing SM, Camacho CV, Wang YD, Piro RM, Herold-Mende C, Wang ZQ, Hofmann TG, Sahm F, von Deimling A, McKinnon PJ, Frappart PO. | 08/31/2023 |
| A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma. | A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.
Petroni M, Fabretti F, Di Giulio S, Nicolis di Robilant V, La Monica V, Moretti M, Belardinilli F, Bufalieri F, Coppa A, Paci P, Corsi A, De Smaele E, Coni S, Canettieri G, Di Marcotullio L, Wang ZQ, Giannini G., Free PMC Article | 09/17/2022 |
| NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis. | NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.
Zhang B, Tang Z, Li L, Lu LY., Free PMC Article | 09/25/2021 |
| Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis. | Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
Chen Y, Sun J, Ju Z, Wang ZQ, Li T., Free PMC Article | 03/20/2021 |
| NBS1 interacts with Notch signaling in neuronal homeostasis. | NBS1 interacts with Notch signaling in neuronal homeostasis.
Zhou ZW, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN, Li TL, Kaether C, Barzilai A, Wang ZQ., Free PMC Article | 11/21/2020 |
| Nbn-Mre11 interaction is required for tumor suppression and genomic integrity. | Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.
Kim JH, Penson AV, Taylor BS, Petrini JHJ., Free PMC Article | 04/4/2020 |
| Loss of Nbn expression is associated with premature hair loss. | Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis.
Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss DE, Frappart L, von Deimling A, Feuerer M, Abdollahi A, Frappart PO., Free PMC Article | 02/3/2018 |
| the essential role of Nbs1 is via its interaction with Mre11 and that most of the Nbs1 protein is dispensable for Mre11 complex functions and suggest that Mre11 and Rad50 directly activate ATM. | The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
Kim JH, Grosbart M, Anand R, Wyman C, Cejka P, Petrini JHJ., Free PMC Article | 11/25/2017 |
| Low NBS1 expression is associated with B-cell lymphomas. | MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Spehalski E, Capper KM, Smith CJ, Morgan MJ, Dinkelmann M, Buis J, Sekiguchi JM, Ferguson DO., Free PMC Article | 10/28/2017 |
| Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired. | NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.
Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S., Free PMC Article | 09/9/2017 |
| findings show that NBS1 is crucial for macrophage function during normal aging | NBS1 is required for macrophage homeostasis and functional activity in mice.
Pereira-Lopes S, Tur J, Calatayud-Subias JA, Lloberas J, Stracker TH, Celada A. | 03/19/2016 |
| TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2 | The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.
Pacheco S, Marcet-Ortega M, Lange J, Jasin M, Keeney S, Roig I., Free PMC Article | 12/26/2015 |
| In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate. | Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo.
Wessendorf P, Vijg J, Nussenzweig A, Digweed M., Free PMC Article | 06/20/2015 |
| Nbs1 mutants initially accumulate replication intermediate, not DSBs. | The essential function of the MRN complex in the resolution of endogenous replication intermediates.
Bruhn C, Zhou ZW, Ai H, Wang ZQ. | 09/27/2014 |
| This report showed that ATM-Chk2-P53 signaling pathway and the AKT/mTOR signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes. | Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes.
Liu B, Chen X, Wang ZQ, Tong WM. | 07/19/2014 |
| JNK signaling and ATR signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice. | The distinct signaling regulatory roles in the cortical atrophy and cerebellar apoptosis of newborn Nbn-deficient mice.
Liu B, Chen X. | 07/12/2014 |
| Nbn and Atm collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner. | Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.
Rodrigues PM, Grigaravicius P, Remus M, Cavalheiro GR, Gomes AL, Rocha-Martins M, Frappart L, Reuss D, McKinnon PJ, von Deimling A, Martins RA, Frappart PO., Free PMC Article | 04/5/2014 |
| the antagonism and redundancy of ATMIN and NBS1 constitute a crucial regulatory mechanism for ATM signaling and function. | Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Zhang T, Penicud K, Bruhn C, Loizou JI, Kanu N, Wang ZQ, Behrens A. | 06/8/2013 |
| Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage. | A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
Li R, Yang YG, Gao Y, Wang ZQ, Tong WM., Free PMC Article | 09/1/2012 |
| NBS1 haploinsufficiency results in increased mammary tumor latency and metastasis. | Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis.
Wan R, Crowe DL. | 09/1/2012 |
| a distinct function of Nbs1 and Atr in neurogenesis | Differential function of NBS1 and ATR in neurogenesis.
Zhou Z, Bruhn C, Wang ZQ. | 05/19/2012 |
| murine cells have evolved mechanisms to ensure the functional redundancy of Pif1 or Nbs1 in the regulation of chromosome healing. | PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.
Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP., Free PMC Article | 03/3/2012 |
| Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage. | Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.
Li T, Wang ZQ. | 01/21/2012 |