| GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway. | GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway.
Zhang Y, Tang X, Liu L, Cai D, Gou S, Hao S, Li Y, Shen J, Chen Y, Zhao Y, Wu X, Li M, Chen M, Li X, Sun Y, Gu L, Li W, Wang F, Zhang Z, Wang X, Deng S, Xiao Z, Yao L, Du F., Free PMC Article | 10/30/2024 |
| Glyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression. | Glyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression.
Kim JY, Jung JH, Jung S, Lee S, Lee HA, Ouh YT, Hong SH., Free PMC Article | 06/26/2024 |
| Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study. | Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study.
Zeng Q, Yang T, Wei W, Zou D, Wei Y, Han F, He J, Huang J, Guo R., Free PMC Article | 12/1/2023 |
| MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation. | MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.
Zhenhai Z, Qi C, Shuchao Z, Zhongqi W, Xue S, Zhijun G, Zhijie M, Jianmin L, Beibei L, Yuanyuan G., Free PMC Article | 10/11/2023 |
| The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus. | The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.
Bora S, Adole PS, Vinod KV, Pillai AA, Ahmed S. | 09/19/2023 |
| H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis. | H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis.
Xie N, Zhang R, Bi Z, Ren W, You K, Hu H, Xu Y, Yao H. | 04/14/2023 |
| High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients. | High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.
Tian X, Wang Y, Ding X, Cheng W. | 06/25/2022 |
| The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136. | The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Cortizo FG, Pfaff D, Wirth A, Schlotterer A, Medert R, Morgenstern J, Weber T, Hammes HP, Fleming T, Nawroth PP, Freichel M, Teleman AA., Free PMC Article | 04/2/2022 |
| Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors. | Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Rabbani N, Thornalley PJ., Free PMC Article | 03/26/2022 |
| Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. | Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Driessen RGH, Kiers D, Schalkwijk CG, Scheijen JLJM, Gerretsen J, Pickkers P, van de Poll MCG, van der Horst ICC, Bergmans DCJJ, Kox M, van Bussel BCT., Free PMC Article | 02/5/2022 |
| GLO 1 and PKClambda Regulate ALDH1-positive Breast Cancer Stem Cell Survival. | GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival.
Motomura H, Tamori S, Yatani MA, Namiki A, Onaga C, Ozaki A, Takasawa R, Mano Y, Sato T, Hara Y, Sato K, Xiong Y, Harada Y, Hanawa T, Tanuma SI, Sasaki K, Ohno S, Akimoto K. | 12/11/2021 |
| Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer. | Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer.
Scheifele C, Zhu Q, Ignatov A, Kalinski T, Nass N. | 10/2/2021 |
| Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons. | Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons.
Hara T, Toyoshima M, Hisano Y, Balan S, Iwayama Y, Aono H, Futamura Y, Osada H, Owada Y, Yoshikawa T., Free PMC Article | 08/21/2021 |
| Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth. | Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth.
Jandova J, Wondrak GT., Free PMC Article | 08/7/2021 |
| The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. | The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
Saeed M, Kausar MA, Singh R, Siddiqui AJ, Akhter A. | 05/29/2021 |
| Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells. | Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells.
Schmidt B, Ferreira C, Alves Passos CL, Silva JL, Fialho E., Free PMC Article | 02/20/2021 |
| LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. | LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1.
Wu Z, Liu Y, Wei L, Han M. | 01/9/2021 |
| Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction. | Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction.
Villanueva M, Michie C, Parent S, Kanaan GN, Rafatian G, Kanda P, Ye B, Liang W, Harper ME, Davis DR., Free PMC Article | 08/22/2020 |
| The most active compound (ST018515) showed an IC50 of 0.34 +/- 0.03 muM, which, compared to reported GLO-I inhibitors, can be considered a potent inhibitor, making it a good candidate for further optimization towards designing more potent GLO-I inhibitors. | Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.
Al-Shar'i NA, Al-Balas QA, Al-Waqfi RA, Hassan MA, Alkhalifa AE, Ayoub NM. | 07/25/2020 |
| Results indicate that the GLO1 loss of function (GLO1 (fs) mutation derived from the schizophrenia patient and the engineered GLO1 (-/-) mutation) impaired the cellular development of iPS cells because of the enhanced carbonyl stress. | Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.
Toyoshima M, Jiang X, Ogawa T, Ohnishi T, Yoshihara S, Balan S, Yoshikawa T, Hirokawa N., Free PMC Article | 07/4/2020 |
| The three genes associated with chronic kidney disease (AGT, GLO1, and SHROOM3) showed associations with both the high levels of oxidatively damaged DNA and genomic instability. | Loci associated with genomic damage levels in chronic kidney disease patients and controls.
Corredor Z, da Silva Filho MI, Rodríguez-Ribera L, Catalano C, Hemminki K, Coll E, Silva I, Diaz JM, Ballarin JA, Henández A, Försti A, Marcos R, Pastor S. | 04/25/2020 |
| Common GLO1 variants do not increase chronic pancreatitis risk. | Common variants in glyoxalase I do not increase chronic pancreatitis risk.
Kaune T, Hollenbach M, Keil B, Chen JM, Masson E, Becker C, Damm M, Ruffert C, Grützmann R, Hoffmeister A, Te Morsche RHM, Cavestro GM, Zuppardo RA, Saftoiu A, Malecka-Panas E, Głuszek S, Bugert P, Lerch MM, Weiss FU, Zou WB, Liao Z, Hegyi P, Drenth JP, Riedel J, Férec C, Scholz M, Kirsten H, Tóth A, Ewers M, Witt H, Griesmann H, Michl P, Rosendahl J., Free PMC Article | 03/14/2020 |
| The schizophrenia case with the highest neurite curvature carried a frame shift mutation in the GLO1 gene, suggesting that oxidative stress due to the GLO1 mutation caused the structural alteration of the neurites. | Three-dimensional alteration of neurites in schizophrenia.
Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K, Itokawa M, Arai M., Free PMC Article | 01/18/2020 |
| Glo1, together with miR-101, might be potential therapeutic targets for metastatic prostate cancer. | Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.
Antognelli C, Cecchetti R, Riuzzi F, Peirce MJ, Talesa VN., Free PMC Article | 10/26/2019 |
| GLO1 may be of functional importance target downstream of MMSET I. | MMSET I acts as an oncoprotein and regulates GLO1 expression in t(4;14) multiple myeloma cells.
Xie Z, Chooi JY, Toh SHM, Yang D, Basri NB, Ho YS, Chng WJ. | 05/25/2019 |