| The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function. | The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
Haykir B, Moser SO, Pastor-Arroyo EM, Schnitzbauer U, Radvanyi Z, Prucker I, Qiu D, Fiedler D, Saiardi A, Jessen HJ, Hernando N, Wagner CA., | 04/10/2024 |
| Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium. | Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
Bhat SA, Malla AB, Oddi V, Sen J, Bhandari R. | 11/20/2023 |
| Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. | Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, Msengi EN, Haubner J, Guo C, Pike DP, Ghoshal S, Ford DA, Neuschwander-Tetri BA, Chakraborty A., Free PMC Article | 03/26/2022 |
| Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction. | Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
Ghoshal S, Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Chakraborty A., Free PMC Article | 03/12/2022 |
| Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival. | Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
Lolla P, Shah A, Unnikannan CP, Oddi V, Bhandari R. | 11/27/2021 |
| Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory. | Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
Kim MG, Zhang S, Park H, Park SJ, Kim S, Chung C., Free PMC Article | 06/5/2021 |
| the unique metabolic sensing properties of IP6K1 guarantees appropriate concentrations of IP7 and thereby both correct basal insulin secretion and intact first phase insulin release. | Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO., Free PMC Article | 08/24/2019 |
| juvenile spermatids from Ip6k1(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression. | IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
Malla AB, Bhandari R. | 05/5/2018 |
| these findings reveal an important role for IP6K1 in regulating Mesenchymal stem/stromal cell fitness and differentiation fate. | IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Boregowda SV, Ghoshal S, Booker CN, Krishnappa V, Chakraborty A, Phinney DG., Free PMC Article | 04/21/2018 |
| IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate. | Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.
Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH., Free PMC Article | 04/14/2018 |
| IP6K1 is a novel regulator of PLIN1 mediated lipolysis | Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Ghoshal S, Tyagi R, Zhu Q, Chakraborty A., Free PMC Article | 11/26/2017 |
| IP6K1 regulates energy metabolism via a mechanism that could potentially be targeted in obesity. | Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Zhu Q, Ghoshal S, Rodrigues A, Gao S, Asterian A, Kamenecka TM, Barrow JC, Chakraborty A., Free PMC Article | 09/2/2017 |
| provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport | Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport.
Chanduri M, Rai A, Malla AB, Wu M, Fiedler D, Mallik R, Bhandari R., Free PMC Article | 07/1/2017 |
| IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression. | Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Jadav RS, Kumar D, Buwa N, Ganguli S, Thampatty SR, Balasubramanian N, Bhandari R., Free PMC Article | 02/25/2017 |
| IP6K1 preferentially bound to the phospholipid phosphatidic acid, and this binding was required for IP6K1 nuclear localization and the regulation of inositol-3-phosphate synthase transcription. | Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells.
Yu W, Ye C, Greenberg ML., Free PMC Article | 12/17/2016 |
| IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. | Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.
Rao F, Xu J, Khan AB, Gadalla MM, Cha JY, Xu R, Tyagi R, Dang Y, Chakraborty A, Snyder SH., Free PMC Article | 04/18/2015 |
| present study demonstrates that IP6K1 physiologically regulates GSK3 kinases. | Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways.
Chakraborty A, Latapy C, Xu J, Snyder SH, Beaulieu JM. | 11/8/2014 |
| FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. | The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.
Niger C, Luciotti MA, Buo AM, Hebert C, Ma V, Stains JP., Free PMC Article | 12/14/2013 |
| IP6K1 has a role in regulation of mammalian hemostasis via its control of platelet polyP levels | Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels.
Ghosh S, Shukla D, Suman K, Lakshmi BJ, Manorama R, Kumar S, Bhandari R. | 11/16/2013 |
| Mouse embryonic fibroblasts (MEFs) lacking IP6K1 exhibit impaired DNA damage repair via homologous recombination. | Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair.
Jadav RS, Chanduri MV, Sengupta S, Bhandari R., Free PMC Article | 03/30/2013 |
| Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions | Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
Bhandari R, Juluri KR, Resnick AC, Snyder SH., Free PMC Article | 01/21/2010 |