| The Abca7[V1613M] variant reduces Abeta generation, plaque load, and neuronal damage. | The Abca7(V1613M) variant reduces Aβ generation, plaque load, and neuronal damage.
Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN., Free PMC Article | 07/22/2024 |
| ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism. | ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Kawatani K, Holm ML, Starling SC, Martens YA, Zhao J, Lu W, Ren Y, Li Z, Jiang P, Jiang Y, Baker SK, Wang N, Roy B, Parsons TM, Perkerson RB 3rd, Bao H, Han X, Bu G, Kanekiyo T., Free PMC Article | 06/13/2024 |
| ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. | ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex.
Iqbal J, Suarez MD, Yadav PK, Walsh MT, Li Y, Wu Y, Huang Z, James AW, Escobar V, Mokbe A, Brickman AM, Luchsinger JA, Dai K, Moreno H, Hussain MM., Free PMC Article | 11/12/2022 |
| Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease. | Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P., Free PMC Article | 10/29/2022 |
| Effects of environmental enrichment on cognitive behavior and the expression of adenosine triphosphate binding cassette transporter A7 in hippocampus of adolescent mice with high fat diet.", trans "A7. | Effects of environmental enrichment on cognitive behavior and the expression of adenosine triphosphate binding cassette transporter A7 in hippocampus of adolescent mice with high fat diet.
Zou G, Su J, Zhang Y, Li F, Li C, Meng X. | 10/24/2020 |
| results demonstrate that ABCA7 loss of function may contribute to Alzheimer disease pathogenesis by altering proper microglial responses to acute inflammatory challenges and during the development of amyloid pathology, providing insight into disease mechanisms and possible treatment strategies | ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T., Free PMC Article | 04/4/2020 |
| Study demonstrates that changes in surface CD1d expression and intracellular trafficking, as well as reduced CD1d localization to lipid rafts, are all caused by the absence of the ATP binding cassette transporter ABCA7. | ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, Fitzgerald ML, Kronenberg M, Hedrick CC., Free PMC Article | 11/3/2018 |
| ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse. | Abca7 deletion does not affect adult neurogenesis in the mouse.
Li H, Karl T, Garner B., Free PMC Article | 12/17/2016 |
| This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease. | ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T., Free PMC Article | 08/13/2016 |
| ABCA7 has a role in Alzheimer amyloid processing | ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.
Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE., Free PMC Article | 01/16/2016 |
| Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta homeostasis in the brain and that this may be related to altered phagocyte function. | Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease.
Kim WS, Li H, Ruberu K, Chan S, Elliott DA, Low JK, Cheng D, Karl T, Garner B., Free PMC Article | 04/27/2013 |
| Male knockout mice exhibited significantly impaired novel object recognition memory.Female knockout mice exhibited impaired spatial reference memory. | Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases.
Logge W, Cheng D, Chesworth R, Bhatia S, Garner B, Kim WS, Karl T., Free PMC Article | 03/9/2013 |
| ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen | Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.
Meurs I, Calpe-Berdiel L, Habets KL, Zhao Y, Korporaal SJ, Mommaas AM, Josselin E, Hildebrand RB, Ye D, Out R, Kuiper J, Van Berkel TJ, Chimini G, Van Eck M., Free PMC Article | 07/14/2012 |
| concluded that statins enhance macrophage phagocytosis through the SREBP-ABCA7 pathway. | HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.
Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S., Free PMC Article | 12/10/2011 |
| Data suggest that extracellular helical apolipoproteins augment ABCA7-associated phagocytosis by stabilizing ABCA7, and show direct enhancement of the host defense system by HDL components. | Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.
Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S., Free PMC Article | 02/26/2011 |
| Mouse spermatozoa in the seminiferous tubules and epididymis express ABCA1, ABCA7 and ABCG1. | ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.
Morales CR, Marat AL, Ni X, Yu Y, Oko R, Smith BT, Argraves WS., Free PMC Article | 01/21/2010 |
| ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues | ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.
Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, Chen W, Martinez LO, Tall AR. | 01/21/2010 |
| genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I | Potential role of ABCA7 in cellular lipid efflux to apoA-I.
Linsel-Nitschke P, Jehle AW, Shan J, Cao G, Bacic D, Lan D, Wang N, Tall AR. | 01/21/2010 |
| ABCA7 plays a novel role in lipid and fat metabolism | Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.
Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW. | 01/21/2010 |