| CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis. | CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis.
Luo JT, Wang YF, Wang Y, Wang CL, Liu RY, Zhang Z. | 04/28/2023 |
| Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B. | Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
Bailey J, Douglas H, Masino L, de Carvalho LPS, Argyrou A., Free PMC Article | 01/1/2022 |
| lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells. | lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells.
García-Venzor A, Mandujano-Tinoco EA, Ruiz-Silvestre A, Sánchez JM, Lizarraga F, Zampedri C, Melendez-Zajgla J, Maldonado V. | 07/24/2021 |
| the protein-protein interacting surface formed in MATa2:MATbeta complexes is explored to demonstrate that several quinolone-based compounds modulate the activity of MATa2 and its mutants, providing a rational for chemical design/intervention responsive to the level of S-Adenosylmethionine in the cellular environment | Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds.
Panmanee J, Bradley-Clarke J, Mato JM, O'Neill PM, Antonyuk SV, Hasnain SS., Free PMC Article | 05/16/2020 |
| Results found that MAT2B was overexpressed in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis for HCC patients. Its silencing could suppress liver cancer cell migration and invasion through the inhibition of EGFR signaling, which suggested that MAT2B might serve as a new prognostic marker for HCC. | MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma.
Wu L, Chen P, Ying J, Zhang Q, Liu F, Lv B, Che Z, Zhang W, Wu M, Zhang J, Yang D, Liu J. | 03/14/2020 |
| MAT2B was markedly increased in osteosarcoma (OS) specimens compared with the normal bone tissues, and it was additionally abundantly expressed in OS cell lines. Inhibition of MAT2B expression caused a marked decrease in proliferation and significant increase in apoptosis. Results demonstrated that MAT2B functions as a tumor oncogene in OS in vivo and in vitro via regulation of EGFR and PCNA. | MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen.
Yuan Y, Wang Y, Liu Z, Sun Y, Yao Y, Yu W, Shen Z., Free PMC Article | 08/31/2019 |
| This study showed that variant upstream of MAT2B whose association is prominent in back, hip, knee, and neck pain-provides preliminary evidence of shared contributing mechanisms at the genetic-molecular level. | Genetic studies of human neuropathic pain conditions: a review.
Zorina-Lichtenwalter K, Parisien M, Diatchenko L., Free PMC Article | 04/6/2019 |
| Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. | Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma.
Lei Y, Zhang B, Zhang Y, Zhao Y, Sun J, Zhang X, Yang S. | 04/8/2017 |
| Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway | Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Peng H, Li TW, Yang H, Moyer MP, Mato JM, Lu SC., Free PMC Article | 12/12/2015 |
| Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. | Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation.
Ramani K, Donoyan S, Tomasi ML, Park S., Free PMC Article | 04/11/2015 |
| resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition. | Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
Yang H, Zheng Y, Li TW, Peng H, Fernandez-Ramos D, Martínez-Chantar ML, Rojas AL, Mato JM, Lu SC., Free PMC Article | 11/2/2013 |
| MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. | MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC., Free PMC Article | 08/31/2013 |
| The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad. | Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
Shafqat N, Muniz JR, Pilka ES, Papagrigoriou E, von Delft F, Oppermann U, Yue WW., Free PMC Article | 06/29/2013 |
| Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. | Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.
Nordgren KK, Peng Y, Pelleymounter LL, Moon I, Abo R, Feng Q, Eckloff B, Yee VC, Wieben E, Weinshilboum RM., Free PMC Article | 05/5/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation. | Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants.
Xia M, Chen Y, Wang LC, Zandi E, Yang H, Bemanian S, Martínez-Chantar ML, Mato JM, Lu SC., Free PMC Article | 08/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.
Martinez CA, Northrup H, Lin JI, Morrison AC, Fletcher JM, Tyerman GH, Au KS. | 04/7/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.
Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT., Free PMC Article | 01/11/2009 |
| differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells. | Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis.
Attia RR, Gardner LA, Mahrous E, Taxman DJ, Legros L, Rowe S, Ting JP, Geller A, Kotb M., Free PMC Article | 01/21/2010 |
| a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B | Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma.
Wang Q, Liu QY, Liu ZS, Qian Q, Sun Q, Pan DY., Free PMC Article | 01/21/2010 |
| Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. | Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
Ramani K, Yang H, Xia M, Ara AI, Mato JM, Lu SC., Free PMC Article | 01/21/2010 |
| Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death. | Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Yang H, Ara AI, Magilnick N, Xia M, Ramani K, Chen H, Lee TD, Mato JM, Lu SC., Free PMC Article | 01/21/2010 |