| Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila. | Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
Li L, Zhang N, Beati SAH, De Las Heras Chanes J, di Pietro F, Bellaiche Y, Müller HJ, Großhans J., Free PMC Article | 11/14/2023 |
| A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction. | A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction.
Cheon Y, Yoon S, Lee JH, Kim K, Kim HJ, Hong SW, Yun YR, Shim J, Kim SH, Lu B, Lee M, Lee S., Free PMC Article | 08/25/2023 |
| The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes. | The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Mysh M, Poulton JS., Free PMC Article | 10/9/2021 |
| Actin-microtubule crosslinker Pod-1 tunes PAR-1 signaling to control synaptic development and tau-mediated synaptic toxicity. | Actin-microtubule crosslinker Pod-1 tunes PAR-1 signaling to control synaptic development and tau-mediated synaptic toxicity.
Kang HY, Kim HJ, Kim K, Oh SI, Yoon S, Kim J, Park S, Cheon Y, Her S, Lee M, Lu B, Lee S., Free PMC Article | 10/31/2020 |
| Par-1 is required for cells to form cortical actin caps following syncytial Drosophila embryo development | Par-1 controls the composition and growth of cortical actin caps during Drosophila embryo cleavage.
Jiang T, Harris TJC., Free PMC Article | 06/6/2020 |
| Par-1 role in the eye during development. | Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
Ansar M, Chung H, Waryah YM, Makrythanasis P, Falconnet E, Rao AR, Guipponi M, Narsani AK, Fingerhut R, Santoni FA, Ranza E, Waryah AM, Bellen HJ, Antonarakis SE., Free PMC Article | 12/7/2019 |
| localization of BRP-an essential active zone scaffolding protein in Drosophila, depends on the precise balance of neuronal Par-1 kinase. | Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses.
Barber KR, Hruska M, Bush KM, Martinez JA, Fei H, Levitan IB, Dalva MB, Wairkar YP., Free PMC Article | 11/30/2019 |
| orb interacts genetically with aPKC and cdc42 and in egg chambers compromised for orb activity, Par-1 and aPKC protein and aPKC mRNA are mislocalized. Moreover, like cdc42-, the defects in Par protein localization appear to be connected to abnormalities in the cortical actin cytoskeleton. | The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte.
Barr J, Charania S, Gilmutdinov R, Yakovlev K, Shidlovskii Y, Schedl P., Free PMC Article | 09/21/2019 |
| Here, the authors show that the kinase PAR-1 is required for dendrite pruning and dendritic microtubule breakdown. | PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila.
Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S., Free PMC Article | 07/15/2017 |
| Shot/Patronin foci are excluded from the oocyte posterior by the Par-1 polarity kinase to generate the polarized microtubule network that localizes axis determinants | Patronin/Shot Cortical Foci Assemble the Noncentrosomal Microtubule Array that Specifies the Drosophila Anterior-Posterior Axis.
Nashchekin D, Fernandes AR, St Johnston D., Free PMC Article | 06/24/2017 |
| These results suggest that tau phosphorylation at Ser262 plays the predominant role in tau stabilization when PAR-1/MARK activity. | Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.
Ando K, Oka M, Ohtake Y, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM., Free PMC Article | 06/3/2017 |
| Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau | Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.
Barber KR, Tanquary J, Bush K, Shaw A, Woodson M, Sherman M, Wairkar YP., Free PMC Article | 05/27/2017 |
| It is also found that Tau's role in photoreceptor cell polarity depends on Par-1 kinase | Role of Tau, a microtubule associated protein, in Drosophila photoreceptor morphogenesis.
Nam SC. | 05/6/2017 |
| aPKC prevents hyper-polarization of junctions as epithelia develop from cellularization to gastrulation by inhibiting a positive feedback loop between Bazooka (Baz)/Par-3 and centrosomes. This loop is driven by Par-1, a kinase known to phosphorylate Baz. | A Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell Adhesion.
Jiang T, McKinley RF, McGill MA, Angers S, Harris TJ. | 08/6/2016 |
| Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association | Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association.
Huang HL, Wang S, Yin MX, Dong L, Wang C, Wu W, Lu Y, Feng M, Dai C, Guo X, Li L, Zhao B, Zhou Z, Ji H, Jiang J, Zhao Y, Liu XY, Zhang L., Free PMC Article | 03/8/2014 |
| These results reveal that Par-1 controls the timing of pole plasm assembly by promoting the localization of oskar mRNA but inhibiting the accumulation of Short Oskar protein. | Oskar is targeted for degradation by the sequential action of Par-1, GSK-3, and the SCF⁻Slimb ubiquitin ligase.
Morais-de-Sá E, Vega-Rioja A, Trovisco V, St Johnston D., Free PMC Article | 11/2/2013 |
| Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Abeta toxicity. | Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila.
Lee S, Wang JW, Yu W, Lu B., Free PMC Article | 06/8/2013 |
| These results suggest that an increase in tau phosphorylation at Ser262 through PAR-1 contributes to tau-mediated neurodegeneration under a pathological condition in which axonal mitochondria is depleted | Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM., Free PMC Article | 01/5/2013 |
| We identify a critical new role for Par-1 kinase: spatiotemporal regulation of Myo-II activity within the border cell cluster through localized inhibition of myosin phosphatase. | Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.
Majumder P, Aranjuez G, Amick J, McDonald JA., Free PMC Article | 08/11/2012 |
| Junctional positioning in the dorsal epithelium depends on the polarity proteins Bazooka and Par-1. | Differential positioning of adherens junctions is associated with initiation of epithelial folding.
Wang YC, Khan Z, Kaschube M, Wieschaus EF., Free PMC Article | 05/26/2012 |
| Regulation of cyclin A localization via Par-1 function plays a critical role in the centrosome orientation checkpoint. | Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells.
Yuan H, Chiang CY, Cheng J, Salzmann V, Yamashita YM., Free PMC Article | 02/4/2012 |
| This organization originated through MT nucleation at the oocyte nucleus and cortex, except at the posterior end of the oocyte, where PAR-1 suppressed nucleation. | A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte.
Parton RM, Hamilton RS, Ball G, Yang L, Cullen CF, Lu W, Ohkura H, Davis I., Free PMC Article | 10/1/2011 |
| The Par genes are not sufficient to polarize the oocyte early and that the activity of the tumor-suppressor gene lethal giant larvae (lgl) is required for the posterior translocation of oocyte-specific proteins, including germline determinants. | lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte.
Fichelson P, Jagut M, Lepanse S, Lepesant JA, Huynh JR. | 03/22/2010 |
| The balance of PAR-1 and PP2A effects on Baz phosphorylation determines neuroblasts polarity. | PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.
Krahn MP, Egger-Adam D, Wodarz A. | 01/21/2010 |
| Data suggest that proper levels of Par-1 at correct position in the oocyte are key to oocyte polarity and that the conserved role of Par-1 and Tau is crucial for the establishment of an AP gradient of microtubules and for AP axis specification. | Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes.
Tian AG, Deng WM., Free PMC Article | 01/21/2010 |