| GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway. | GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway.
Sun Y, Han Y. | 09/11/2024 |
| Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15. | Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.
Zeng B, Chen Y, Chen H, Zhao Q, Sun Z, Liu D, Li X, Zhang Y, Wang J, Xing HR. | 02/22/2023 |
| GNA15 was not expressed in normal neuroendocrine cells but was overexpressed in gastroenteropancreatic neuroendocrine neoplasia cell lines. | GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.
Zanini S, Giovinazzo F, Alaimo D, Lawrence B, Pfragner R, Bassi C, Modlin I, Kidd M. | 12/19/2015 |
| Data indicate the importance of Galpha16 as a downstream effector of the non-canonical Wnt signaling pathway and as a potential therapeutic target for the treatment of non small cell lung cancer. | Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
Avasarala S, Bikkavilli RK, Van Scoyk M, Zhang W, Lapite A, Hostetter L, Byers JT, Heasley LE, Sohn JW, Winn RA., Free PMC Article | 08/30/2014 |
| G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients. | Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.
Giovinazzo F, Malpeli G, Zanini S, Parenti M, Piemonti L, Colombatti M, Valenti MT, Dalle Carbonare L, Scarpa A, Sinnett-Smith J, Rozengurt E, Bassi C, Innamorati G. | 08/31/2013 |
| This review summarizes the specific features that distinguish Galpha15/GNA15 (G15 alpha subunit) from all other alpha subunits of the Gq class. G15 is a heterotrimeric G protein complex that is named after its alpha subunit. | The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.
Giannone F, Malpeli G, Lisi V, Grasso S, Shukla P, Ramarli D, Sartoris S, Monsurró V, Krampera M, Amato E, Tridente G, Colombatti M, Parenti M, Innamorati G. | 07/2/2012 |
| This paper shows how G alpha 15 and other Gq class members phosphorylate PKD in differing patterns | Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.
Waldron RT, Innamorati G, Torres-Marquez ME, Sinnett-Smith J, Rozengurt E., Free PMC Article | 07/2/2012 |
| The paper describes G alpha 15 resistance to arrestin-desensitization making it differ from other heterotrimeric G proteins (Gq, Gs, Gi, G12/13 class) | Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.
Innamorati G, Giannone F, Guzzi F, Rovati GE, Accomazzo MR, Chini B, Bianchi E, Schiaffino MV, Tridente G, Parenti M. | 07/2/2012 |
| beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras | Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.
Liu AM, Lo RKh, Guo EX, Ho MK, Ye RD, Wong YH., Free PMC Article | 09/17/2011 |
| The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. | CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades.
Lee MM, Wong YH. | 01/21/2010 |
| Co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP. | Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signaling.
Lo RK, Liu AM, Wise H, Wong YH. | 01/21/2010 |
| Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism | Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.
Lo RK, Cheung H, Wong YH. | 01/21/2010 |
| G protein-coupled receptors activate STAT3 via G alpha(16), a G alpha subunit which is primarily expressed in hematopoietic cells. | Regulation of STAT3 activity by G16-coupled receptors.
Wu EH, Lo RK, Wong YH. | 01/21/2010 |
| role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16. | Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16).
Ho BY, Current L, Drewett JG. | 01/21/2010 |
| Results suggest that the G(q) class proteins are degraded through the proteasome pathway and that cellular localization and/or other protein interactions determine their stability. | Proteasome involvement in the degradation of the G(q) family of Galpha subunits.
Johansson BB, Minsaas L, Aragay AM. | 01/21/2010 |
| Megakaryocytopoiesis was accompanied by down-regulation of the 43 kDa and 46 kDa variants of G16alpha, constant expression of Gsalpha, and up-regulation of Gqalpha and Gialpha1/2. | Biogenesis of G-protein mediated calcium signaling in human megakaryocytes.
den Dekker E, Gorter G, van der Vuurst H, Heemskerk JW, Akkerman JW. | 01/21/2010 |