| MiR-30c-5p-Targeted Regulation of GNAI2 Improves Neural Function Injury and Inflammation in Cerebral Ischemia-Reperfusion Injury. | MiR-30c-5p-Targeted Regulation of GNAI2 Improves Neural Function Injury and Inflammation in Cerebral Ischemia-Reperfusion Injury.
Deng X, Zeng Y, Ding D. | 11/7/2024 |
| Galphai2-induced conductin/axin2 condensates inhibit Wnt/beta-catenin signaling and suppress cancer growth. | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.
Miete C, Solis GP, Koval A, Brückner M, Katanaev VL, Behrens J, Bernkopf DB., Free PMC Article | 02/26/2022 |
| Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy.
Zhang Z, Ji Z, He J, Lu Y, Tian W, Zheng C, Chen H, Zhang Q, Yang F, Zhang M, Yin Y, Jiang R, Chu WM, Zhang W, Sun B. | 01/15/2022 |
| GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. | GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer.
Ha JH, Jayaraman M, Yan M, Dhanasekaran P, Isidoro C, Song YS, Dhanasekaran DN., Free PMC Article | 10/2/2021 |
| Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals. | Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals.
Lutz PE, Almeida D, Filliol D, Jollant F, Kieffer BL, Turecki G., Free PMC Article | 08/14/2021 |
| The Galphai protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane. | The Gαi protein subclass selectivity to the dopamine D(2) receptor is also decided by their location at the cell membrane.
Polit A, Rysiewicz B, Mystek P, Błasiak E, Dziedzicka-Wasylewska M., Free PMC Article | 08/14/2021 |
| S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. | S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis.
Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y., Free PMC Article | 08/7/2021 |
| Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins-In Silico Study. | Preferential Coupling of Dopamine D(2S) and D(2L) Receptor Isoforms with G(i1) and G(i2) Proteins-In Silico Study.
Żuk J, Bartuzi D, Matosiuk D, Kaczor AA., Free PMC Article | 10/3/2020 |
| CXCL2-CXCR2 axis mediates through Galphai-2 and Galphaq/11 to promote tumorigenesis and contributes to cancer stem cell properties of CPT-11-resistant LoVo cells. | CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.
Chen MC, Baskaran R, Lee NH, Hsu HH, Ho TJ, Tu CC, Lin YM, Viswanadha VP, Kuo WW, Huang CY. | 05/9/2020 |
| We conclude that Gia2 protein acts at two different levels which are both dependent and independent of GPCR signaling to induce cell migration and invasion in prostate cancer cells and its action is downstream of PI3-kinase-AKT-Rac1 axis. | Novel role of Giα2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells.
Caggia S, Chunduri H, Millena AC, Perkins JN, Venugopal SV, Vo BT, Li C, Tu Y, Khan SA., Free PMC Article | 10/5/2019 |
| genotyping at GNAI2 may be a useful biomarker in identifying individuals at risk for developing salt-sensitive blood pressure. | GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study.
Zhang X, Frame AA, Williams JS, Wainford RD., Free PMC Article | 09/7/2019 |
| 3.6 A structure of the human A1R in complex with adenosine and heterotrimeric Gi2 protein determined by Volta phase plate cryo-electron microscopy | Structure of the adenosine-bound human adenosine A(1) receptor-G(i) complex.
Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A. | 01/19/2019 |
| The data show that the nonpalmitoylated CB1 receptor significantly reduced its association with Galphai2 . | Role of palmitoylation of cysteine 415 in functional coupling CB(1) receptor to Gα(i2) protein.
Oddi S, Totaro A, Scipioni L, Dufrusine B, Stepniewski TM, Selent J, Maccarrone M, Dainese E. | 03/17/2018 |
| MicroRNA-222-3p/GNAI2/AKT signaling axis inhibits epithelial ovarian cancer cell growth and is associated with good overall survival. | MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival.
Fu X, Li Y, Alvero A, Li J, Wu Q, Xiao Q, Peng Y, Hu Y, Li X, Yan W, Guo K, Zhou W, Wang Y, Liu J, Zhang Y, Mor G, Wen J, Yin G., Free PMC Article | 02/24/2018 |
| These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3, with no evidence for functional coupling to Galphagust. | Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G(αi1,2,3).
Kim D, Woo JA, Geffken E, An SS, Liggett SB., Free PMC Article | 08/5/2017 |
| Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing. | The GPSM2/LGN GoLoco motifs are essential for hearing.
Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB., Free PMC Article | 10/22/2016 |
| Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma. | Suppression of GNAI2 message in ovarian cancer.
Raymond JR Jr, Appleton KM, Pierce JY, Peterson YK., Free PMC Article | 10/31/2015 |
| Galpha(i2) activates the TRPC4 channel by direct binding. | Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process.
Myeong J, Kwak M, Jeon JP, Hong C, Jeon JH, So I. | 08/8/2015 |
| We observed increased expression of Galphai1/3 in wounded human skin and keloid skin tissues, suggesting the possible involvement of Galphai1/3 in wound healing and keloid formation. | Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.
Zhang YM, Zhang ZQ, Liu YY, Zhou X, Shi XH, Jiang Q, Fan DL, Cao C. | 02/28/2015 |
| Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 subunit, were studied. | Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron.
Jeon JP, Roh SE, Wie J, Kim J, Kim H, Lee KP, Yang D, Jeon JH, Cho NH, Kim IG, Kang DE, Kim HJ, So I. | 05/31/2014 |
| Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase -dependent manner | Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.
Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M., Free PMC Article | 03/22/2014 |
| There is an interaction between the activated Gsalpha subunit and membrane lipid microdomains in the pathophysiology of some major depressive disorders. | Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study.
Mooney JJ, Samson JA, McHale NL, Pappalarado KM, Alpert JE, Schildkraut JJ., Free PMC Article | 01/25/2014 |
| These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 Ca(2+) channels | The familial hemiplegic migraine type 1 mutation K1336E affects direct G protein-mediated regulation of neuronal P/Q-type Ca2+ channels.
Garza-López E, González-Ramírez R, Gandini MA, Sandoval A, Felix R. | 10/26/2013 |
| The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. | Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.
Chishiki K, Kamakura S, Yuzawa S, Hayase J, Sumimoto H. | 08/31/2013 |
| Gialpha2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration. | The essential role of Giα2 in prostate cancer cell migration.
Zhong M, Clarke S, Vo BT, Khan SA., Free PMC Article | 04/27/2013 |