| EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis. | EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis.
Zhang W, Chen L, Lu X, Dong X, Feng M, Tu Y, Wang Z. | 06/17/2024 |
| EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death. | EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.
Wu J, Xu X, Duan J, Chai Y, Song J, Gong D, Wang B, Hu Y, Han T, Ding Y, Liu Y, Li J, Cao X., Free PMC Article | 02/20/2024 |
| miRNA-126a-3p participates in hippocampal memory via alzheimer's disease-related proteins. | miRNA-126a-3p participates in hippocampal memory via alzheimer's disease-related proteins.
Xue B, Qu Y, Zhang X, Xu XF. | 11/5/2022 |
| Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. | Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.
Lehne F, Pokrant T, Parbin S, Salinas G, Großhans J, Rust K, Faix J, Bogdan S., Free PMC Article | 05/14/2022 |
| EFhd2 brain interactome reveals its association with different cellular and molecular processes. | EFhd2 brain interactome reveals its association with different cellular and molecular processes.
Soliman AS, Umstead A, Grabinski T, Kanaan NM, Lee A, Ryan J, Lamp J, Vega IE., Free PMC Article | 01/15/2022 |
| B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2. | B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2.
Reimer D, Meyer-Hermann M, Rakhymzhan A, Steinmetz T, Tripal P, Thomas J, Boettcher M, Mougiakakos D, Schulz SR, Urbanczyk S, Hauser AE, Niesner RA, Mielenz D. | 05/29/2021 |
| Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. | Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.
Giricz Z, Makkos A, Schreckenberg R, Pöling J, Lörchner H, Kiss K, Bencsik P, Braun T, Schulz R, Ferdinandy P, Schlüter KD., Free PMC Article | 02/20/2021 |
| Study in LPS-induced or cecal ligation and puncture-induced sepsis in mice report that swiprosin-1 (also known as EFhd2) plays an important role in the macrophage immune response to sepsis in mice. Swiprosin-1 depletion causes higher mortality, more severe organ dysfunction, restrained macrophage recruitment in the lung and kidney, and attenuated inflammatory cytokine production. | Swiprosin-1 deficiency impairs macrophage immune response of septic mice.
Zhang S, Tu Y, Sun YM, Li Y, Wang RM, Cao Y, Li L, Zhang LC, Wang ZB., Free PMC Article | 11/2/2019 |
| EFHD2 is an important regulator of T cell cytotoxicity and further studies should evaluate its role in T cell-mediated inflammation | EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity.
Peled M, Dragovich MA, Adam K, Strazza M, Tocheva AS, Vega IE, Mor A., Free PMC Article | 07/20/2019 |
| Together with our finding of severe hippocampal tauopathy in Efhd2 knockout mice, these data connect Efhd2 to impaired synaptic plasticity as present in Alzheimer's disease and identify a role of Efhd2 in neuronal survival and synaptic integration in the adult hippocampus | Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis.
Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B., Free PMC Article | 01/19/2019 |
| These results indicate that swiprosin-1 in the vestibular nuclei is a critical determinant of the susceptibility to motion sickness. | Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice.
Wang ZB, Han P, Tong LC, Luo Y, Su WH, Wei X, Yu XH, Liu WY, Zhang XH, Lei H, Li ZZ, Wang F, Chen JG, Ma TH, Su DF, Li L., Free PMC Article | 10/20/2018 |
| this study shows that EFhd2/swiprosin-1 regulates LPS-induced macrophage recruitment via enhancing actin polymerization and cell migration | EFhd2/swiprosin-1 regulates LPS-induced macrophage recruitment via enhancing actin polymerization and cell migration.
Tu Y, Zhang L, Tong L, Wang Y, Zhang S, Wang R, Li L, Wang Z. | 09/1/2018 |
| These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss. | The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice.
Morowski M, Brachs S, Mielenz D, Nieswandt B, Dütting S., Free PMC Article | 06/20/2015 |
| EFhd2 is a neuronal protein that interferes with kinesin-mediated transport. | The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D., Free PMC Article | 05/16/2015 |
| a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE. | Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity.
Brachs S, Turqueti-Neves A, Stein M, Reimer D, Brachvogel B, Bösl M, Winkler T, Voehringer D, Jäck HM, Mielenz D. | 03/7/2015 |
| Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183 | Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin.
Huh YH, Kim SH, Chung KH, Oh S, Kwon MS, Choi HW, Rhee S, Ryu JH, Park ZY, Jun CD, Song WK., Free PMC Article | 01/25/2014 |
| Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain. | Functional and structural analysis of the conserved EFhd2 protein.
Ferrer-Acosta Y, Rodríguez Cruz EN, Vaquer Adel C, Vega IE., Free PMC Article | 10/26/2013 |
| EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration. | EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease.
Ferrer-Acosta Y, Rodríguez-Cruz EN, Orange F, De Jesús-Cortés H, Madera B, Vaquer-Alicea J, Ballester J, Guinel MJ, Bloom GS, Vega IE., Free PMC Article | 08/10/2013 |
| Swip-1 provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent BCR-induced calcium flux. | Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.
Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D. | 05/3/2010 |
| These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway. | Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway.
Thylur RP, Kim YD, Kwon MS, Oh HM, Kwon HK, Kim SH, Im SH, Chun JS, Park ZY, Jun CD. | 01/21/2010 |
| The identification of a novel calcium-binding protein associated with tau protein in terminally ill tauopathy mouse model suggests that this association may play an important physiological and/or pathological role. | A novel calcium-binding protein is associated with tau proteins in tauopathy.
Vega IE, Traverso EE, Ferrer-Acosta Y, Matos E, Colon M, Gonzalez J, Dickson D, Hutton M, Lewis J, Yen SH., Free PMC Article | 01/21/2010 |
| study shows that swiprosin-1 may regulate lifespan and BCR signaling thresholds in immature B cells | The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis.
Avramidou A, Kroczek C, Lang C, Schuh W, Jäck HM, Mielenz D. | 01/21/2010 |