| study first addressed in detail the LF/fOPN interaction and proposed a LF:fOPN 4/1 maximal stoichiometry. | Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex.
Ameziane-Le Hir S, Bourgeois D, Basset C, Hagège A, Vidaud C. | 05/19/2018 |
| This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions. | Osteopontin binds multiple calcium ions with high affinity and independently of phosphorylation status.
Kläning E, Christensen B, Sørensen ES, Vorup-Jensen T, Jensen JK. | 04/4/2015 |
| Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk. | Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Dudemaine PL, Thibault C, Alain K, Bissonnette N. | 03/7/2015 |
| Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells. | Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
Santarelli A, Mascitti M, Orsini G, Memè L, Rocchetti R, Tiriduzzi P, Sampalmieri F, Putignano A, Procaccini M, Lo Muzio L, Bambini F. | 11/22/2014 |
| osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen. | Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.
Rodriguez DE, Thula-Mata T, Toro EJ, Yeh YW, Holt C, Holliday LS, Gower LB., Free PMC Article | 08/16/2014 |
| Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter. | Characterization of UO2(2+) binding to osteopontin, a highly phosphorylated protein: insights into potential mechanisms of uranyl accumulation in bones.
Qi L, Basset C, Averseng O, Quéméneur E, Hagège A, Vidaud C. | 08/16/2014 |
| Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation. | Expression and regulation of secreted phosphoprotein 1 in the bovine corpus luteum and effects on T lymphocyte chemotaxis.
Poole DH, Ndiaye K, Pate JL. | 07/19/2014 |
| OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm. | Osteopontin reduces biofilm formation in a multi-species model of dental biofilm.
Schlafer S, Raarup MK, Wejse PL, Nyvad B, Städler BM, Sutherland DS, Birkedal H, Meyer RL., Free PMC Article | 01/12/2013 |
| This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs. | Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase.
Ek-Rylander B, Andersson G. | 03/1/2010 |
| the present study is the first to demonstrate functionally that SPP1 directly binds specific integrins to promote trophectoderm cell migration and attachment to luminal epithelium that may be critical to conceptus elongation and implantation. | Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.
Erikson DW, Burghardt RC, Bayless KJ, Johnson GA. | 01/21/2010 |
| Polymorphisms in the genomic sequence of SPP1 can influence the number of somatic cells in milk and, potentially, influence susceptibility to mastitis. | Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis.
Alain K, Karrow NA, Thibault C, St-Pierre J, Lessard M, Bissonnette N., Free PMC Article | 01/21/2010 |
| SPP1 (also known as osteopontin) has a significant role in the modulation of milk protein gene expression. | A functional genomics approach to evaluate candidate genes located in a QTL interval for milk production traits on BTA6.
Sheehy PA, Riley LG, Raadsma HW, Williamson P, Wynn PC. | 01/21/2010 |
| OPN may act as a carrier protein for LF in milk, and modulate the potent antimicrobial and immunostimulatory activities of the LF protein. | Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin.
Yamniuk AP, Burling H, Vogel HJ. | 01/21/2010 |
| The role of OPN phosphate groups in adsorption to, incorporation into and inhibition of calcium oxalate monohydrate crystals was studied by comparing OPN isoforms differing in phosphorylation. | Role of phosphate groups in inhibition of calcium oxalate crystal growth by osteopontin.
Hunter GK, Grohe B, Jeffrey S, O'Young J, Sørensen ES, Goldberg HA. | 01/21/2010 |
| Results of this study confirm for the first time, the expression of Opn in the ileum and ileocecal lymph node of cattle with paratuberculosis. | Osteopontin immunoreactivity in the ileum and ileocecal lymph node of dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis.
Karcher EL, Johnson CS, Beitz DC, Stabel JR. | 01/21/2010 |
| Opn may be a key regulator against Mycobacterium avium ssp. paratuberculosis infection | Osteopontin: a novel cytokine involved in the regulation of Mycobacterium avium subspecies paratuberculosis infection in periparturient dairy cattle.
Karcher EL, Bayles DO, Bannantine JP, Beitz DC, Stabel JR. | 01/21/2010 |
| The binding of bovine seminal proteins A1, A2, and 30 kDa and osteopontin to spermatozoa and the effects of oviductal fluid on protein binding are reported. | Binding patterns of bovine seminal plasma proteins A1/A2, 30 kDa and osteopontin on ejaculated sperm before and after incubation with isthmic and ampullary oviductal fluid.
Souza CE, Moura AA, Monaco E, Killian GJ. | 01/21/2010 |
| In this study, we have expressed bovine osteopontin in a prokaryotic system and identified the seven amino acid residues phosphorylated in vitro by CKII. | Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification.
Saad FA, Salih E, Glimcher MJ., Free PMC Article | 01/21/2010 |
| topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein | Complete topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein and their biological implications.
Salih E, Flückiger R. | 01/21/2010 |
| the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6 | Fine-mapping milk production quantitative trait loci on BTA6: analysis of the bovine osteopontin gene.
Schnabel RD, Kim JJ, Ashwell MS, Sonstegard TS, Van Tassell CP, Connor EE, Taylor JF., Free PMC Article | 01/21/2010 |
| The relationship between polymorphisms in SPP1 and several factors affecting growth and development in beef cattle was studied. | Evaluation in beef cattle of six deoxyribonucleic acid markers developed for dairy traits reveals an osteopontin polymorphism associated with postweaning growth.
White SN, Casas E, Allan MF, Keele JW, Snelling WM, Wheeler TL, Shackelford SD, Koohmaraie M, Smith TP. | 01/21/2010 |
| findings show significant association of osteoponitin variants with milk composition traits | The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations.
Khatib H, Zaitoun I, Wiebelhaus-Finger J, Chang YM, Rosa GJ. | 01/21/2010 |