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    DGAT1 diacylglycerol O-acyltransferase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282609, updated on 30-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Role of diacylglycerol O-acyltransferase 1 (DGAT1) in lipolysis and autophagy of adipose tissue from ketotic dairy cows.

    Role of diacylglycerol O-acyltransferase 1 (DGAT1) in lipolysis and autophagy of adipose tissue from ketotic dairy cows.
    Xu Q, Fan Y, Mauck J, Loor JJ, Sun X, Jia H, Li X, Xu C.

    07/23/2024
    Interaction of DGAT1 polymorphism, parity, and acetate supplementation on feeding behavior, milk synthesis, and plasma metabolites.

    Interaction of DGAT1 polymorphism, parity, and acetate supplementation on feeding behavior, milk synthesis, and plasma metabolites.
    Matamoros C, Dechow CD, Harvatine KJ., Free PMC Article

    11/30/2023
    Analysis of the impact of DGAT1 p.M435L and p.K232A variants on pre-mRNA splicing in a full-length gene assay.

    Analysis of the impact of DGAT1 p.M435L and p.K232A variants on pre-mRNA splicing in a full-length gene assay.
    Gaiani N, Bourgeois-Brunel L, Rocha D, Boulling A., Free PMC Article

    06/16/2023
    Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day.

    Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day.
    Sanjayaranj I, MacGibbon AKH, Holroyd SE, Janssen PWM, Blair HT, Lopez-Villalobos N., Free PMC Article

    03/30/2023
    DGAT1 K232A polymorphism is associated with milk production traits in Chinese cattle.

    DGAT1 K232A polymorphism is associated with milk production traits in Chinese cattle.
    Li F, Cai C, Qu K, Liu J, Jia Y, Hanif Q, Chen N, Zhang J, Chen H, Huang B, Lei C.

    01/1/2022
    The functions and mechanisms of sequence differences of DGAT1 gene on milk fat synthesis between dairy cow and buffalo.

    The functions and mechanisms of sequence differences of DGAT1 gene on milk fat synthesis between dairy cow and buffalo.
    Bhattarai D, Dad R, Worku T, Xu S, Ullah F, Zhang M, Liang X, Den T, Fan M, Zhang S.

    03/13/2021
    These findings demonstrated that milk fat percentage, somatic cell count (SCC), somatic cell score (SCS), serum cytokines interleukin 6 (IL-6) and interferon gamma (IFN-gamma) showed significant associations (P < 0.05) with at least one or more identified single nucleotide polymorphisms (SNPs).

    Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins.
    Khan MZ, Wang D, Liu L, Usman T, Wen H, Zhang R, Liu S, Shi L, Mi S, Xiao W, Yu Y.

    06/20/2020
    report on the interaction effect of diacylglycerol O-acyltransferase 1 K232A polymorphism in cows and season on the triacylglycerol composition in milk fat

    The DGAT1 K232A polymorphism and feeding modify milk fat triacylglycerol composition.
    Pacheco-Pappenheim S, Yener S, van Valenberg HJF, Tzompa-Sosa DA, Bovenhuis H.

    10/26/2019
    the effects of dietary linseed oil, DGAT1, and the interaction between dietary linseed oil and DGAT1 on CH4 and H2 emission, energy and N metabolism, lactation performance, ruminal fermentation, and rumen bacterial and archaeal composition of dairy cows

    Linseed oil and DGAT1 K232A polymorphism: Effects on methane emission, energy and nitrogen metabolism, lactation performance, ruminal fermentation, and rumen microbial composition of Holstein-Friesian cows.
    van Gastelen S, Visker MHPW, Edwards JE, Antunes-Fernandes EC, Hettinga KA, Alferink SJJ, Hendriks WH, Bovenhuis H, Smidt H, Dijkstra J.

    07/7/2018
    Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively. The DGAT1 GC/GC allele was associated with lower milk fat and protein content, lower saturated fatty acid levels, and higher polyunsaturated FA

    Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation.
    Carvajal AM, Huircan P, Dezamour JM, Subiabre I, Kerr B, Morales R, Ungerfeld EM.

    03/18/2017
    study showed that the DGAT1 K232A polymorphism has major effects on FA and mineral composition of bovine milk; effects are relevant in relation to cow health, human health, and functional properties of milk fat and milk protein

    Effects of the diacylglycerol o-acyltransferase 1 (DGAT1) K232A polymorphism on fatty acid, protein, and mineral composition of dairy cattle milk.
    Bovenhuis H, Visker MHPW, Poulsen NA, Sehested J, van Valenberg HJF, van Arendonk JAM, Larsen LB, Buitenhuis AJ.

    12/17/2016
    Association of a novel mutation in DGAT1 that may be responsible for unsaturated milk fat in cattle.

    Phenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fat.
    Lehnert K, Ward H, Berry SD, Ankersmit-Udy A, Burrett A, Beattie EM, Thomas NL, Harris B, Ford CA, Browning SR, Rawson P, Verkerk GA, van der Does Y, Adams LF, Davis SR, Jordan TW, MacGibbon AK, Spelman RJ, Snell RG., Free PMC Article

    12/12/2015
    An effect of DGAT1 identified on subcutaneous fat thickness.

    CAPN1, CAST, and DGAT1 genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in a beef cattle population selected for haplotype and allele equalization.
    Tait RG Jr, Shackelford SD, Wheeler TL, King DA, Keele JW, Casas E, Smith TP, Bennett GL.

    10/24/2015
    Russian and Kazakh populations of the Kazakh white-headed breed were characterized by a high content of the AA genotype of RORC (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975)

    [Polymorphisms of bGH, RORC, and DGAT1 genes in Russian beef cattle breeds].
    Gorlov IF, Fedunin AA, Randelin DA, Sulimova GE.

    06/20/2015
    Studied the occurrence of the DGAT1 p.Lys232Ala polymorphism in Romanian Holstein cattle and Romanian Buffalo breeds and further investigated its possible influence on fat percentage and fatty acid profiles.

    Influence of DGAT1 K232A polymorphism on milk fat percentage and fatty acid profiles in Romanian holstein cattle.
    Tăbăran A, Balteanu VA, Gal E, Pusta D, Mihaiu R, Dan SD, Tăbăran AF, Mihaiu M.

    04/18/2015
    Novel SNPs and INDEL polymorphism in DGAT1 are associated with milk production and protein and fat milk composition.

    Novel SNPs and INDEL polymorphisms in the 3'UTR of DGAT1 gene: in silico analyses and a possible association.
    Rosse Ida C, Steinberg Rda S, Coimbra RS, Peixoto MG, Verneque RS, Machado MA, Fonseca CG, Carvalho MR.

    02/7/2015
    Single nucleotide polymorphisms in the DGAT1 gene significantly effected fat distribution in Chinese commercial cattle.

    Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle.
    Yuan Z, Li J, Li J, Gao X, Gao H, Xu S.

    06/22/2013
    effects of K232A polymorphism on milk fat composition in winter and summer

    Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions.
    Duchemin S, Bovenhuis H, Stoop WM, Bouwman AC, van Arendonk JA, Visker MH.

    06/8/2013
    results indicated that knockdown of DGAT1 expression significantly reduced triglyceride content in bovine mammary epithelial cells

    RNA interference-mediated knockdown of DGAT1 decreases triglyceride content of bovine mammary epithelial cell line.
    Lu C, Yang R, Shen B, Osman H, Zhang Y, Yan S, Zhang L, Zhao Z., Free PMC Article

    05/4/2013
    The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

    Effect of polymorphisms in the leptin, leptin receptor and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on bovine milk composition.
    Glantz M, Lindmark Månsson H, Stålhammar H, Paulsson M.

    05/4/2013
    pleiotropic effects of polymorphism Ala to Lys amino acid substitution at position 232 in mammary gland tissue

    Pleiotropic effects of polymorphism of the gene diacylglycerol-O-transferase 1 (DGAT1) in the mammary gland tissue of dairy cows.
    Mach N, Blum Y, Bannink A, Causeur D, Houee-Bigot M, Lagarrigue S, Smits MA.

    02/2/2013
    The impact of different alleles of DGAT1 and leptin on milk production in Giorlando cattle is reported.

    Productive performance of the dairy cattle Girolando breed mediated by the fat-related genes DGAT1 and LEP and their polymorphisms.
    Cardoso SR, Queiroz LB, Goulart VA, Mourão GB, Benedetti E, Goulart LR.

    07/14/2012
    Genotype KK has the greatest effect on all milk composition content traits, while genotype AA has the greatest effect on yield traits. It can be concluded that the DGAT1 gene can be used as a gene marker for assisted selection in milk composition traits.

    Effects of acyl-CoA:diacylglycerol acyl transferase 1 (DGAT1) gene on milk production traits in crossbred Holstein dairy cattle.
    Molee A, Duanghaklang N, Na-Lampang P.

    06/30/2012
    No differential allelic expression was observed for the DGAT1 genes in bovine fetal tissues.

    Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle.
    Niciura SC, Ibelli AM, Gouveia GV, Gromboni JG, Rocha MI, de Souza MM, de Mello SS, Regitano LC.

    03/3/2012
    The present study investigated putative interaction effects between the DGAT1 K232A mutation and the polygenic term (i.e., all genes except DGAT1) for 5 milk production traits in the German Holstein dairy cattle population.

    Short communication: evidence for a major gene by polygene interaction for milk production traits in German Holstein dairy cattle.
    Streit M, Neugebauer N, Meuwissen TH, Bennewitz J.

    04/30/2011
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