| Structural analysis of human G-protein-coupled receptor 17 ligand binding sites. | Structural analysis of human G-protein-coupled receptor 17 ligand binding sites.
Konda Mani S, Thiyagarajan R, Yli-Harja O, Kandhavelu M, Murugesan A. | 04/21/2023 |
| Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication. | Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.
Mutharasu G, Murugesan A, Konda Mani S, Yli-Harja O, Kandhavelu M. | 05/14/2022 |
| Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells. | Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.
Lin KN, Zhang K, Zhao W, Huang SY, Li H., Free PMC Article | 03/19/2022 |
| GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma. | GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma.
Nguyen P, Doan P, Murugesan A, Ramesh T, Rimpilainen T, Candeias NR, Yli-Harja O, Kandhavelu M. | 02/19/2022 |
| Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis. | Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.
Raffaele S, Gelosa P, Bonfanti E, Lombardi M, Castiglioni L, Cimino M, Sironi L, Abbracchio MP, Verderio C, Fumagalli M., Free PMC Article | 11/22/2021 |
| G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. | G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.
Liu H, Xing R, Ou Z, Zhao J, Hong G, Zhao TJ, Han Y, Chen Y., Free PMC Article | 11/6/2021 |
| Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles. | Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles.
Conley JM, Sun H, Ayers KL, Zhu H, Chen R, Shen M, Hall MD, Ren H., Free PMC Article | 08/28/2021 |
| The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients. | The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.
Angelini J, Marangon D, Raffaele S, Lecca D, Abbracchio MP., Free PMC Article | 06/5/2021 |
| FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane. | FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.
Yang J, Gong Z, Lu YB, Xu CJ, Wei TF, Yang MS, Zhan TW, Yang YH, Lin L, Liu J, Tang C, Zhang WP. | 02/2/2021 |
| GPR17 may mediate hypoxia injury in RGC-5 cells, while the knockdown of GPR17 can reduce the hypoxia injury | [G protein-coupled receptor 17 is involved in CoCl(2)-induced hypoxic injury in RGC-5 cells].
Lin K, Lin M, Gu Y, Zhang S, Huang S., Free PMC Article | 06/1/2019 |
| In silico and ex vivo validation experiments provided the deep understanding of ligand binding with GPR17 and the present findings reported here may lead to use these two compounds as a potential activator of GPR17 for therapeutic intervention. | Identification of novel GPR17-agonists by structural bioinformatics and signaling activation.
Saravanan KM, Palanivel S, Yli-Harja O, Kandhavelu M. | 07/14/2018 |
| Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation. | SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.
Meraviglia V, Ulivi AF, Boccazzi M, Valenza F, Fratangeli A, Passafaro M, Lecca D, Stagni F, Giacomini A, Bartesaghi R, Abbracchio MP, Ceruti S, Rosa P. | 01/6/2018 |
| uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds. | The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E. | 05/13/2017 |
| GPR17 gene disruption does not alter food intake or glucose homeostasis in mice. | GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.
Mastaitis J, Min S, Elvert R, Kannt A, Xin Y, Ochoa F, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J., Free PMC Article | 05/9/2015 |
| This review summarizes knowledge about role of GPR17 receptors in physiology and pathology of nervous system, with special attention to remyelination processes. | [Recently identified GPR17 receptors--characteristics and role in pathology of the nervous system].
Wypych D. | 04/11/2015 |
| Low levels of GRK2/GRK5 causes a slow and not complete desensitization/down-regulation of GPR17. | Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?
Daniele S, Trincavelli ML, Fumagalli M, Zappelli E, Lecca D, Bonfanti E, Campiglia P, Abbracchio MP, Martini C. | 11/29/2014 |
| Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17. | Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.
Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E., Free PMC Article | 06/21/2014 |
| Data validate GPR17 as a target for neurorepair | Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury.
Franke H, Parravicini C, Lecca D, Zanier ER, Heine C, Bremicker K, Fumagalli M, Rosa P, Longhi L, Stocchetti N, De Simoni MG, Weber M, Abbracchio MP., Free PMC Article | 03/22/2014 |
| Nucleotides, nucleotide sugars, and cysteinyl leukotrienes do not promote activation of GPR17 in five different cell lines, nor does GPR17 have signaling properties. | Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17.
Qi AD, Harden TK, Nicholas RA., Free PMC Article | 11/30/2013 |
| analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells | The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.
Fratangeli A, Parmigiani E, Fumagalli M, Lecca D, Benfante R, Passafaro M, Buffo A, Abbracchio MP, Rosa P., Free PMC Article | 05/4/2013 |
| A functional cross-talk exists between cysteinyl-leukotriene and purinergic sites at GPR17; the latter have a hierarchy in producing desensitizing signals. | Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands.
Daniele S, Trincavelli ML, Gabelloni P, Lecca D, Rosa P, Abbracchio MP, Martini C. | 10/1/2011 |
| REVIEW: functional properties and in vivo biology | EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
Nørregaard K, Benned-Jensen T, Rosenkilde MM. | 09/17/2011 |
| We present the first isoform-specific characterization of GPR17 and show that differences exist between the isoforms in expression pattern and pharmacological profile; the two human isoforms might serve tissue-specific functions | Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants.
Benned-Jensen T, Rosenkilde MM., Free PMC Article | 07/19/2010 |
| long-GPR17 isoform is a functional receptor that is stimulated by both uracil nucleotides and cysteinyl leukotrienes | Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells.
Pugliese AM, Trincavelli ML, Lecca D, Coppi E, Fumagalli M, Ferrario S, Failli P, Daniele S, Martini C, Pedata F, Abbracchio MP. | 01/21/2010 |
| Molecular dynamics simulations suggest that GPR17 nucleotide binding pocket is similar to that described for the other P2Y receptors, although only one of the 3 basic residues that have been typically involved in ligand recognition is conserved (Arg255). | GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.
Parravicini C, Ranghino G, Abbracchio MP, Fantucci P., Free PMC Article | 01/21/2010 |