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    EPHA10 EPH receptor A10 [ Homo sapiens (human) ]

    Gene ID: 284656, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.

    A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
    Huang S, Ma L, Liu X, He C, Li J, Hu Z, Jiang L, Liu Y, Liu X, Feng Y, Cai X.

    02/24/2023
    EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.

    EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
    Zhao W, Liu L, Li X, Xu S.

    08/27/2022
    Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.

    Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
    Peng J, Zhang D., Free PMC Article

    02/5/2022
    Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.

    Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
    Chen YL, Yen YC, Jang CW, Wang SH, Huang HT, Chen CH, Hsiao JR, Chang JY, Chen YW., Free PMC Article

    08/14/2021
    Cataloguing the dead: breathing new life into pseudokinase research.

    Cataloguing the dead: breathing new life into pseudokinase research.
    Shrestha S, Byrne DP, Harris JA, Kannan N, Eyers PA., Free PMC Article

    05/22/2021
    we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage.

    Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex.
    Li Y, Jin L, Ye F, Ma Q, Yang Z, Liu D, Yang J, Ma D, Gao Q., Free PMC Article

    03/10/2018
    We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.

    EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.
    Johnson C, Segovia B, Kandpal RP., Free PMC Article

    01/28/2017
    Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

    Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers.
    Nagano K, Maeda Y, Kanasaki S, Watanabe T, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S.

    04/11/2015
    Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here.

    Eph receptor A10 has a potential as a target for a prostate cancer therapy.
    Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S.

    09/27/2014
    EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression.

    Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.
    Nagano K, Kanasaki S, Yamashita T, Maeda Y, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S., Free PMC Article

    09/6/2014
    EPHA10 does not interact with EPHB6 in breast neoplasms

    A paradigm shift in EPH receptor interaction: biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell lines.
    Fox BP, Kandpal RP.

    12/10/2011
    CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10.

    Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells.
    Alonso-C LM, Trinidad EM, de Garcillan B, Ballesteros M, Castellanos M, Cotillo I, Muñoz JJ, Zapata AG.

    01/21/2010
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