| Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners. | Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners.
László L, Kurilla A, Tilajka Á, Pancsa R, Takács T, Novák J, Buday L, Vas V., Free PMC Article | 08/21/2024 |
| Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells. | Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells.
Jacksi M, Schad E, Tantos A., Free PMC Article | 05/20/2024 |
| Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial-Mesenchymal Transition (EMT) Process. | Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial-Mesenchymal Transition (EMT) Process.
Kurilla A, László L, Takács T, Tilajka Á, Lukács L, Novák J, Pancsa R, Buday L, Vas V., Free PMC Article | 10/30/2023 |
| Comprehensive bioinformatics and experimental analysis of SH3PXD2B reveals its carcinogenic effect in gastric carcinoma. | Comprehensive bioinformatics and experimental analysis of SH3PXD2B reveals its carcinogenic effect in gastric carcinoma.
Zhu Y, Hu Y, Wang P, Dai X, Fu Y, Xia Y, Sun L, Ruan S. | 06/19/2023 |
| Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells. | Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells.
Jacksi M, Schad E, Buday L, Tantos A., Free PMC Article | 01/28/2023 |
| Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4. | Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4.
Mehes E, Barath M, Gulyas M, Bugyik E, Geiszt M, Szoor A, Lanyi A, Czirok A., Free PMC Article | 10/31/2020 |
| Significance of the Tks4 scaffold protein in bone tissue homeostasis. | Significance of the Tks4 scaffold protein in bone tissue homeostasis.
Vas V, Kovács T, Körmendi S, Bródy A, Kudlik G, Szeder B, Mező D, Kállai D, Koprivanacz K, Merő BL, Dülk M, Tóvári J, Vajdovich P, Şenel ŞN, Özcan I, Helyes Z, Dobó-Nagy C, Buday L., Free PMC Article | 10/10/2020 |
| Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells. | Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells.
Szeder B, Tárnoki-Zách J, Lakatos D, Vas V, Kudlik G, Merő B, Koprivanacz K, Bányai L, Hámori L, Róna G, Czirók A, Füredi A, Buday AL., Free PMC Article | 08/22/2020 |
| The interaction of Tks4 with Src may result in the long term stabilization of the kinase in its active conformation, leading to prolonged Src activity following epidermal growth factor stimulation. | EGF Regulates the Interaction of Tks4 with Src through Its SH2 and SH3 Domains.
Dülk M, Szeder B, Glatz G, Merő BL, Koprivanacz K, Kudlik G, Vas V, Sipeki S, Cserkaszky A, Radnai L, Buday L. | 04/6/2019 |
| We report a sibling pair with Frank-ter Haar syndrome (FTHS) caused by a homozygous, novel mutation pLys133Glnfs*13 in the SH3PXD2B gene. | Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair.
Chang TC, Bauer M, Puerta HS, Greenberg MB, Cavuoto KM. | 06/16/2018 |
| Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation. | The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.
Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA., Free PMC Article | 02/24/2018 |
| Misfolded Frank-ter Haar syndrome protein Tks4(R43W) is transported via the microtubule system to the aggresomes. | Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes.
Ádám C, Fekete A, Bőgel G, Németh Z, Tőkési N, Ovádi J, Liliom K, Pesti S, Geiszt M, Buday L., Free PMC Article | 03/12/2016 |
| a new function for Tks4 in the regulation of growth factor-dependent cell migration. | Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.
Bögel G, Gujdár A, Geiszt M, Lányi Á, Fekete A, Sipeki S, Downward J, Buday L., Free PMC Article | 11/24/2012 |
| SH3PXD2B is a scaffold protein that plays a key role in regulating the actin cytoskeleton via Src and cortactin. | The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading.
Lányi Á, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, Petrovszki E, Kis-Tóth K, Sirokmány G, Rajnavölgyi É, Terhorst C, Buday L, Geiszt M., Free PMC Article | 01/21/2012 |
| Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins. | Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.
Gianni D, DerMardirossian C, Bokoch GM., Free PMC Article | 07/23/2011 |
| The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation. | c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.
Gianni D, Taulet N, DerMardirossian C, Bokoch GM., Free PMC Article | 06/25/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development. | Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.
Iqbal Z, Cejudo-Martin P, de Brouwer A, van der Zwaag B, Ruiz-Lozano P, Scimia MC, Lindsey JD, Weinreb R, Albrecht B, Megarbane A, Alanay Y, Ben-Neriah Z, Amenduni M, Artuso R, Veltman JA, van Beusekom E, Oudakker A, Millán JL, Hennekam R, Hamel B, Courtneidge SA, van Bokhoven H., Free PMC Article | 03/22/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.
Vogel CI, Greene B, Scherag A, Müller TD, Friedel S, Grallert H, Heid IM, Illig T, Wichmann HE, Schäfer H, Hebebrand J, Hinney A., Free PMC Article | 03/25/2009 |