| Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. | Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
Yang D, Tang M, Zhang M, Ren H, Li X, Zhang Z, He B, Peng S, Wang W, Fang D, Song Y, Xiong Y, Liu ZZ, Liang L, Shi W, Fu C, Hu Y, Jose PA, Zhou L, Han Y, Zeng C. | 03/31/2023 |
| Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. | Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.
Yang J, Hall JE, Jose PA, Chen K, Zeng C., Free PMC Article | 11/12/2022 |
| Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. | Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.
Cao N, Tang H, Tian M, Gong X, Xu Z, Zhou B, Lan C, Chen C, Qu S, Zheng S, Ren H, Fan C, Jose PA, Zeng C, Xia T., Free PMC Article | 12/25/2021 |
| Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population. | Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
Du B, Jia X, Tian W, Yan X, Wang N, Cai D, Li X, Zhang H, Jin M, Wu N, Qiu C, Zhang Q. | 12/25/2021 |
| Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension. | Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.
Yang J, Villar VAM, Jose PA, Zeng C., Free PMC Article | 12/4/2021 |
| Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang. | Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.
Jiang W, Wang X, Li R, Wang P, Shan G, Jia X, Gu M., Free PMC Article | 11/13/2021 |
| The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. | The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
Li L, Fu W, Gong X, Chen Z, Tang L, Yang D, Liao Q, Xia X, Wu H, Liu C, Tian M, Zeng A, Zhou L, Jose PA, Chen K, Wang WE, Zeng C., Free PMC Article | 06/5/2021 |
| Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells. | Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells.
Luo Y, Huang X, Yang J, Huang L, Li R, Wu Q, Jiang X. | 09/5/2020 |
| GRK4 gene variants in humans (GRK4 A>65L, A>142V, and A>486V) are associated with Hypertension in several but not all ethnic groups. GRK4 gene variants impair the function of D1R and D3R and abet the function of AT1R. These lead to enhancement of renal sodium reabsorption and impaired ability to excrete a sodium load that eventually leads to hypertension. Acknowledgments | Gastrorenal Axis.
Jose PA, Felder RA, Yang Z, Zeng C, Eisner GM., Free PMC Article | 01/20/2018 |
| On normal salt diet, renal CuZnSOD and ECSOD proteins were similar but renal MnSOD was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice. | Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.
Diao Z, Asico LD, Villar VAM, Zheng X, Cuevas S, Armando I, Jose PA, Wang X., Free PMC Article | 12/16/2017 |
| A novel function of GRK4 on triggering a p53-independent cellular senescence, which involves an intricate signaling network. | G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling.
Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, Wedegaertner PB, Jiang X., Free PMC Article | 11/11/2017 |
| the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients. | Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
Sanada H, Yoneda M, Yatabe J, Williams SM, Bartlett J, White MJ, Gordon LN, Felder RA, Eisner GM, Armando I, Jose PA., Free PMC Article | 10/1/2016 |
| Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis] | Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
Zhang H, Sun ZQ, Liu SS, Yang LN., Free PMC Article | 10/1/2016 |
| Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK function. | Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor.
Kuwasako K, Sekiguchi T, Nagata S, Jiang D, Hayashi H, Murakami M, Hattori Y, Kitamura K, Kato J. | 06/28/2016 |
| hGRK4gamma(142V) phosphorylates histone deacetylase type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R expression and greater pressor response to angiotensin II. | Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
Wang Z, Zeng C, Villar VA, Chen SY, Konkalmatt P, Wang X, Asico LD, Jones JE, Yang Y, Sanada H, Felder RA, Eisner GM, Weir MR, Armando I, Jose PA., Free PMC Article | 05/21/2016 |
| A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children. | Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.
Lee M, Kim MK, Kim SM, Park H, Park CG, Park HK., Free PMC Article | 02/6/2016 |
| The C-terminal region of FMRP interacts with a domain of GRK4 mRNA that is folded in four stem loops. | The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.
Maurin T, Melko M, Abekhoukh S, Khalfallah O, Davidovic L, Jarjat M, D'Antoni S, Catania MV, Moine H, Bechara E, Bardoni B., Free PMC Article | 01/16/2016 |
| GRK4alpha is more similar to GRK2 than GRK6. A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop | Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Allen SJ, Parthasarathy G, Darke PL, Diehl RE, Ford RE, Hall DL, Johnson SA, Reid JC, Rickert KW, Shipman JM, Soisson SM, Zuck P, Munshi SK, Lumb KJ., Free PMC Article | 12/12/2015 |
| GRK4 genetic polymorphism plays an important role in the regulation of hypertension. | G protein-coupled receptor kinase 4: role in hypertension.
Yang J, Villar VA, Jones JE, Jose PA, Zeng C., Free PMC Article | 08/1/2015 |
| Mutations in GRK4 gene is associated with stress fracture. | Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
Friedman E, Moran DS, Ben-Avraham D, Yanovich R, Atzmon G., Free PMC Article | 04/11/2015 |
| Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase | Buffalo colostrum β-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase.
Chougule RA, P S, Salimath BP, Sosalegowda AH. | 04/19/2014 |
| This study provides a mechanism by which GRK4, via regulation of arterial AT(1)R expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension. | Role of GRK4 in the regulation of arterial AT1 receptor in hypertension.
Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C., Free PMC Article | 03/8/2014 |
| internalization of agonist-activated D1R is regulated by both SNX5 and GRK4, and that SNX5 is critical to the recycling of the receptor to the plasma membrane | Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension.
Villar VA, Armando I, Sanada H, Frazer LC, Russo CM, Notario PM, Lee H, Comisky L, Russell HA, Yang Y, Jurgens JA, Jose PA, Jones JE., Free PMC Article | 07/6/2013 |
| The significant association was also found for rs2960306 polymorphism in the GRK4 gene among Europeans. | Pooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk.
Liu C, Xi B., Free PMC Article | 09/22/2012 |
| GRK-4 polymorphisms predict blood pressure response to dietary modification in Black subjects with mild-to-moderate hypertension. | G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.
Rayner B, Ramesar R, Steyn K, Levitt N, Lombard C, Charlton K. | 08/11/2012 |