| Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF. | Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF.
Wang L, Sha H, He X, Xie Y, Deng J, Chen J, Li G, Yang J., Free PMC Article | 03/8/2024 |
| Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches. | Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches.
Song P, Li P, Huang Z, Yuan Y, Wei M, Wang C, Zhang G, Ji M, Guan H., Free PMC Article | 12/1/2023 |
| Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress. | Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress.
Subbotina AY, Martyusheva AS, Ratmirov AM, Abramova AY, Alekseeva IV, Pertsov SS. | 02/14/2023 |
| Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis. | Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis.
Zhong YM, Zhang LL, Lu WT, Shang YN, Zhou HY. | 05/14/2022 |
| IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation. | IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation.
Deng M, Wang J, Wu H, Wang M, Cao D, Li J, Wu Y, Gong J., Free PMC Article | 01/9/2021 |
| Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells. | Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.
Zogbi C, Oliveira NC, Levy D, Bydlowski SP, Bassaneze V, Neri EA, Krieger JE., Free PMC Article | 12/12/2020 |
| Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia. | Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia.
Ting SM, Zhao X, Zheng X, Aronowski J., Free PMC Article | 09/26/2020 |
| Shashen-Maidong decoction can improve the immune function of RP rats by increasing IFN-gamma concentration and decreasing IL-4 concentration, possibly by increasing the relative ratio of IFN-gamma/IL-4 to regulate the immune imbalance of Th1/Th2. | Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats.
Yang Y, Zhou Y., Free PMC Article | 12/28/2019 |
| this study shows that IL-4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes | Interleukin 4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes.
Szczepankiewicz D, Skrzypski M, Pruszyńska-Oszmałek E, Kołodziejski PA, Sassek M, Stefańska B, Nowak KW, Szczepankiewicz A. | 06/29/2019 |
| Bacterial overgrowth associated with bacterial translocation is linked to intestinal over-expression of IFN-gamma, IL-4, IL-17 and mucin-2 in cholestasis. | Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.
Vega-Magaña N, Delgado-Rizo V, García-Benavides L, Del Toro-Arreola S, Segura-Ortega J, Morales ASMZ, Zepeda-Nuño JS, Escarra-Senmarti M, Gutiérrez-Franco J, Haramati J, Bueno-Topete MR. | 04/27/2019 |
| age-related decrease in IL-4 expression exacerbated surgery-induced cognitive deficits and exaggerated the neuroinflammatory responses | Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4.
Li Z, Liu F, Ma H, White PF, Yumul R, Jiang Y, Wang N, Cao X. | 03/24/2018 |
| Addition of 20 (3) and 40 (6) mg/L (mg/kg BW) of boron to drinking water significantly increased rat serum IgG concentrations, splenic IFN-gamma and IL-4 expression as well as the number of splenic CD3(+), CD4(+) and proliferating cell nuclear antigen (PCNA)(+) cells. | Boron Affects Immune Function Through Modulation of Splenic T Lymphocyte Subsets, Cytokine Secretion, and Lymphocyte Proliferation and Apoptosis in Rats.
Jin E, Li S, Ren M, Hu Q, Gu Y, Li K. | 01/27/2018 |
| IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response | IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response.
Minardi S, Corradetti B, Taraballi F, Byun JH, Cabrera F, Liu X, Ferrari M, Weiner BK, Tasciotti E. | 08/19/2017 |
| Data show that the ratio of peripheral blood CD4(+)/CD8(+) T lymphocytes and the levels of connexin-40 (Cx40), interleukins IL-2, IL-4 and IL-6 are significantly elevated in SH rats. | [An increase in the ratio of peripheral blood CD4+/CD8+ T lymphocytes and the levels of connexin 40 and inflammatory factors in spontaneously hypertensive rats].
Wang A, Zhang H, Zhang L, Li X, Li L, Si J, Ma K. | 07/30/2016 |
| Formoterol synergizes with des-ciclesonide to inhibit IL-4 expression in IgE/antigen-induced mast cells by inhibiting JNK activation. | Formoterol synergy with des-ciclesonide inhibits IL-4 expression in IgE/antigen-induced mast cells by inhibiting JNK activation.
Sun YH, Ge LT, Jiang JX, Shen HJ, Jia YL, Dong XW, Sun Y, Xie QM. | 05/21/2016 |
| CaSR activation promoted T-cell apoptosis and the secretion of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-4. | Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis.
Wu CL, Wu QY, Du JJ, Zeng JY, Li TT, Xu CQ, Sun YH. | 03/7/2015 |
| Stimulating hippocampal microglia with the peptide neurotransmitter VIP via VPAC1 receptors increases production of IL-4 which promotes their trophic and proliferative effects on neural stem/progenitor cells | Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release.
Nunan R, Sivasathiaseelan H, Khan D, Zaben M, Gray W., Free PMC Article | 02/7/2015 |
| IL-4 was found to augment the mRNA expression of ICAM-1. | Interleukin (IL)-4 induces production of cytokine-induced neutrophil chemoattractants (CINCs) and intercellular adhesion molecule (ICAM)-1 in lungs of asthmatic rats.
Guo YL, Huang H, Zeng DX, Zhao JP, Fang HJ, Lavoie JP. | 09/13/2014 |
| IL-4 has a modulatory effect on the enzymatic compartment of the antioxidant defense system in the brain of rats. | Effect of interleukin-4 on antioxidant protection of the brain in rats during acute emotional stress.
Kalinichenko LS, Pertsov SS, Koplik EV. | 08/9/2014 |
| IL-4 promoted the activation of effector cells to mediate rejection and did not support alloantigen-specific Treg that could transfer specific tolerance. | Cytokines affecting CD4(+) T regulatory cells in transplant tolerance. Interleukin-4 does not maintain alloantigen specific CD4(+)CD25(+) Treg.
Plain KM, Verma ND, Tran GT, Nomura M, Boyd R, Robinson CM, Hodgkinson SJ, Hall BM. | 07/12/2014 |
| PDIA3 might be potentially involve into the occurence and development of acute rejection response in renal transplantation and increased plasma IL-2, IL-4, IL-6, and CRP levels play an important role to prevent acute kidney allograft rejection in rats. | PDIA3 mRNA expression and IL-2, IL-4, IL-6, and CRP levels of acute kidney allograft rejection in rat.
Chen G, Mi J, Xiao MZ, Fu YR. | 07/14/2012 |
| The level of IL-4 is elevated in masseter muscle of both sexes following chemically induced inflammation. | Changes in intramuscular cytokine levels during masseter inflammation in male and female rats.
Niu KY, Ro JY., Free PMC Article | 11/12/2011 |
| The purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD in muscle and adipose tissue. | Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats.
Rosa Neto JC, Lira FS, Zanchi NE, Oyama LM, Pimentel GD, Santos RV, Seelaender M, Oller do Nascimento CM., Free PMC Article | 09/24/2011 |
| Garlicin could increase the level of INF-gamma and decrease the level of IL4 significantly in allergic rhinitis. | [Effect of garlicin on the serum levels of interleukin 4 and interferon gamma in allergic rhinitis model in rats].
Li YX, Chen D, Li TY, Feng LQ, Xu G, Wen WP. | 03/26/2011 |
| Treatment with intranasal interferon gamma can inhibit production of IL4 and IL5 in allergic rhinitis. | [Treatment of allergic rhinitis rats by intranasal interferon gamma].
Li Q, Zhang YD, Sun CW, Chen YL, Du YH, Zhao GJ, Zhang DL. | 03/19/2011 |