| Role of RGC-32 in multiple sclerosis and neuroinflammation - few answers and many questions. | Role of RGC-32 in multiple sclerosis and neuroinflammation - few answers and many questions.
Tatomir A, Cuevas J, Badea TC, Muresanu DF, Rus V, Rus H., Free PMC Article | 10/15/2022 |
| RGC-32' dual role in smooth muscle cells and atherogenesis. | RGC-32' dual role in smooth muscle cells and atherogenesis.
Vlaicu SI, Tatomir A, Fosbrink M, Nguyen V, Boodhoo D, Cudrici C, Badea TC, Rus V, Rus H. | 05/28/2022 |
| Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling. | Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS. | 05/8/2021 |
| Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progression. | Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progression.
Zhao P, Wang B, Zhang Z, Zhang W, Liu Y., Free PMC Article | 08/29/2020 |
| Study findings suggest that diminished RGC-32 expression and M2 macrophage polarization were associated with the pro-inflammatory microenvironment of psoriasis. | Decreased expression of response gene to complement 32 in psoriasis and its association with reduced M2 macrophage polarization.
Kim HJ, Jang J, Lee EH, Jung S, Roh JY, Jung Y. | 08/17/2019 |
| the extent of Pumilio binding to the endogenous RGC-32 mRNA in EBV-infected cell lines also correlated with RGC-32 protein expression. Our data demonstrate the importance of RGC-32 for the survival of EBV-immortalised B cells and identify Pumilio as a key regulator of RGC-32 translation. | Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32.
Brocard M, Khasnis S, Wood CD, Shannon-Lowe C, West MJ., Free PMC Article | 07/20/2019 |
| RGC32 facilitates epithelial-mesenchymal transition of colorectal cancer cells by activating Smad/Sip1 signaling. | RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.
Wang XY, Li SN, Zhu HF, Hu ZY, Zhong Y, Gu CS, Chen SY, Liu TF, Li ZG., Free PMC Article | 12/1/2018 |
| This study demonstrated the up-regulation of RGC-32 contributed to the imbalance of Treg/Th17 cells in patients with Dilated Cardiomyopathy. [RGC-32] | Response Gene to Complement-32 Promotes the Imbalance of Treg/Th17 in Patients with Dilated Cardiomyopathy.
Li B, Zhou W, Tang X, Wang W, Pan J, Tan M. | 12/23/2017 |
| RGC-32 mediates human aortic endothelial cell migration through the regulation of RhoA and ROCK1 expression. | RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migration.
Vlaicu SI, Tatomir A, Boodhoo D, Ito T, Fosbrink M, Cudrici C, Mekala AP, Ciriello J, Crişan D, Boţan E, Rus V, Rus H. | 06/3/2017 |
| RGCC may be a candidate cell cycle target for neuroprotection during the onset of Alzheimer's disease. | Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.
Counts SE, Mufson EJ., Free PMC Article | 04/29/2017 |
| RGC-32 expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4. | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.
Zhao P, Gao D, Wang Q, Song B, Shao Q, Sun J, Ji C, Li X, Li P, Qu X., Free PMC Article | 08/13/2016 |
| Data suggest that expression of RGC32 is down-regulated in placental trophoblasts in women with pre-eclampsia as compared to women with normal term pregnancies; silencing RGC32 expression by RNA interference inhibits trophoblast migration/invasion. | Expression of RGC32 in human normal and preeclamptic placentas and its role in trophoblast cell invasion and migration.
Wang QJ, Song BF, Zhang YH, Ma YY, Shao QQ, Liu J, Qu X. | 12/12/2015 |
| Suggest that RGC32 is involved in tumorigenesis of human lung cancer, inducing apoptosis and inhibiting cell growth, migration, and invasion. | Knockdown of response gene to complement 32 (RGC32) induces apoptosis and inhibits cell growth, migration, and invasion in human lung cancer cells.
Xu R, Shang C, Zhao J, Han Y, Liu J, Chen K, Shi W. | 10/31/2015 |
| In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene. | C5a stimulates the proliferation of breast cancer cells via Akt-dependent RGC-32 gene activation.
Lu Y, Hu XB. | 07/4/2015 |
| results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis. | Response gene to complement 32 protein promotes macrophage phagocytosis via activation of protein kinase C pathway.
Tang R, Zhang G, Chen SY., Free PMC Article | 12/20/2014 |
| RGC32 promotes cell migration and invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-kappaB signaling pathway. | Overexpression of response gene to complement 32 (RGC32) promotes cell invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-κB signaling pathway.
Sun Q, Yao X, Ning Y, Zhang W, Zhou G, Dong Y. | 11/30/2013 |
| data suggest RGC-32 plays a dual role in multiple sclerosis, both as a regulator of T-cells mediated apoptosis and as a promoter of TGF-beta-mediated profibrotic effects in astrocytes | Dual role of Response gene to complement-32 in multiple sclerosis.
Tegla CA, Cudrici CD, Azimzadeh P, Singh AK, Trippe R 3rd, Khan A, Chen H, Andrian-Albescu M, Royal W 3rd, Bever C, Rus V, Rus H. | 04/6/2013 |
| analysis of upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells, due to transcriptional activation by high levels of the differentially expressed RUNX1c transcription factor | Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells.
Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ., Free PMC Article | 07/21/2012 |
| Data demonstrate that RGC-32 interacts with Smad3 to mediate the epithelial-mesenchymal transition of human renal proximal tubular cells. | Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells.
Guo X, Jose PA, Chen SY., Free PMC Article | 08/27/2011 |
| methylation-associated down-regulation of RGC32 plays an important role in the pathogenesis of NSCLC, particularly in females | Promoter methylation of the RGC32 gene in nonsmall cell lung cancer.
Kim DS, Lee JY, Lee SM, Choi JE, Cho S, Park JY. | 04/2/2011 |
| RGC-32 may contribute to the development of colon cancer by regulating chromatin assembly. | Epigenetic modifications induced by RGC-32 in colon cancer.
Vlaicu SI, Tegla CA, Cudrici CD, Fosbrink M, Nguyen V, Azimzadeh P, Rus V, Chen H, Mircea PA, Shamsuddin A, Rus H., Free PMC Article | 03/1/2010 |
| RGC-32 plays an important homeostatic role in that it contributes to differentiating the pathways for vascular endothelial growth factor and fibroblast growth factor 2 in angiogenesis and provides a new target for ischemic disorder and tumor therapies. | Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.
An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J., Free PMC Article | 01/21/2010 |
| RGC-32 plays a critical role in TGF-beta-induced epithelial-mesenchymal transition of renal tubular cells | RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells.
Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY., Free PMC Article | 01/21/2010 |
| Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 dependent and this is in part through regulation of Akt and growth factor release. | Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
Fosbrink M, Cudrici C, Tegla CA, Soloviova K, Ito T, Vlaicu S, Rus V, Niculescu F, Rus H., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.
Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, Ovarian Cancer Association Consortium. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Quaye L, Dafou D, Ramus SJ, Song H, Gentry-Maharaj A, Notaridou M, Hogdall E, Kjaer SK, Christensen L, Hogdall C, Easton DF, Jacobs I, Menon U, Pharoah PD, Gayther SA. | 03/25/2009 |