| TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation. | TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation.
Xue C, Meng H, Niu W, Li M, Wei J, Chen S, Zheng L, Duan Y, Deng H, Tang F, Fan S, Tan M, Xiong W, Zhou M. | 10/15/2024 |
| Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE. | Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.
Huang K, Wu Y, Fan W, Zhao Y, Xue M, Liu H, Tang Y, Li J. | 08/31/2023 |
| BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma. | BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Li M, Wei Y, Liu Y, Wei J, Zhou X, Duan Y, Chen S, Xue C, Zhan Y, Zheng L, Deng H, Tang F, Fan S, Xiong W, Li G, Tan M, Zhou M., Free PMC Article | 02/16/2023 |
| Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes. | Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
Agbo L, Loehr J, Kougnassoukou Tchara PE, Lambert JP. | 01/14/2023 |
| LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling. | LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.
Li S, Sun J, Ma J, Zhou C, Yang X, Zhang S, Huang L, Jia H, Shao Y, Zhang E, Zheng M, Zhao Q, Zang L., Free PMC Article | 12/17/2022 |
| BRD7 restrains TNF-alpha-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling. | BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
Li H, Yang T, Chen T, Liu Y, Pang Y, Yang L. | 09/24/2022 |
| Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. | Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.
Li S, Huang Z, Zhu Y, Yan J, Li J, Chen J, Zhou J, Zhang Y, Chen W, Xu K, Ye W. | 10/16/2021 |
| Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer. | Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.
Vivenza D, Garrone O, Brizio R, Mantovani F, Del Sal G, Merlano M, Crook T, Lo Nigro C. | 02/6/2021 |
| PARP1 induces the degradation of BRD7. | Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.
Hu K, Wu W, Li Y, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E, Yin D., Free PMC Article | 05/2/2020 |
| c-Myc transactivates miR-141 expression and that BRD7, a direct target of c-Myc, serves as a cofactor of c-Myc and forms a negative feedback loop with c-Myc in miR-141 transcription in NPC. | BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
Liu Y, Zhao R, Wei Y, Li M, Wang H, Niu W, Zhou Y, Qiu Y, Fan S, Zhan Y, Xiong W, Zhou Y, Li X, Li Z, Li G, Zhou M., Free PMC Article | 05/11/2019 |
| BRD7 was positively correlated with BAK levels in breast cancer tissues, and the survival rate of patients with low BAK and BRD7 expression was significantly lower than that of patients with high BAK and BRD7 expression. In addition, BRD7 activated BAK promoter activity and induced BAK expression in an indirect manner. | Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.
Ma J, Niu W, Wang X, Zhou Y, Wang H, Liu F, Liu Y, Guo J, Xiong W, Zeng Z, Fan S, Li X, Nie X, Li G, Gui R, Luo Y, Zhou M., Free PMC Article | 03/9/2019 |
| the transcriptional signature of low BRD7 expressing cells is associated with increased angiogenesis. | A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7).
van Beijnum JR, Nowak-Sliwinska P, van Berkel M, Wong TJ, Griffioen AW., Free PMC Article | 06/23/2018 |
| our data indicated that BRD7 may serve as a tumor suppressor in hepatocellular carcinoma | Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma.
Chen CL, Wang Y, Pan QZ, Tang Y, Wang QJ, Pan K, Huang LX, He J, Zhao JJ, Jiang SS, Zhang XF, Zhang HX, Zhou ZQ, Weng de S, Xia JC., Free PMC Article | 12/9/2017 |
| Results demonstrate a novel function of BRD7 in TGF-beta signaling. BRD7 interacts with the Smad tumor suppressor complex, and enhances both DNA-binding ability and transcriptional activity of Smads. BRD7 functions in growth inhibition and tumor suppression partly as a transcriptional co-activator of Smads. | Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-β responses.
Liu T, Zhao M, Liu J, He Z, Zhang Y, You H, Huang J, Lin X, Feng XH., Free PMC Article | 09/9/2017 |
| the expression of miR-141 in BRD7-overexpressing NPC cells could partially reverse the tumor suppressive effect of BRD7 on cell proliferation and tumor growth in vitro and in vivo. | miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma.
Liu Y, Zhao R, Wang H, Luo Y, Wang X, Niu W, Zhou Y, Wen Q, Fan S, Li X, Xiong W, Ma J, Li X, Tan M, Li G, Zhou M., Free PMC Article | 11/19/2016 |
| constructed a regulating network of BRD7 downstream genes, and this network suggests multiple feedback regulations of the pathways. Furthermore, we validated BIRC2, BIRC3, TXN2, and NOTCH1 genes as direct, functional BRD7 targets | Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network.
Xu K, Xiong W, Zhou M, Wang H, Yang J, Li X, Chen P, Liao Q, Deng H, Li X, Li G, Zeng Z. | 10/29/2016 |
| Propose that the balance between BRD7 function and Ras/Raf/MEK/ERK activity is important for determining the outcomes of HCV infection and HCC development. | Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, Wu K, Wu J. | 05/21/2016 |
| BRD7 promoter hypermethylation is an indicator of well differentiated oral squamous cell carcinomas. | BRD7 promoter hypermethylation as an indicator of well differentiated oral squamous cell carcinomas.
Balasubramanian A, Subramaniam R, Narayanan V, Annamalai T, Ramanathan A. | 12/12/2015 |
| Data indicate that bromodomain-containing protein 7 (BRD7) was a direct target of microRNA-410 (miR-410). | MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer.
Li D, Yang Y, Zhu G, Liu X, Zhao M, Li X, Yang Q. | 10/31/2015 |
| lower BRD7 expression is an indicator for poor prognosis in patients with osteosarcoma. | Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.
Hu K, Liao D, Wu W, Han AJ, Shi HJ, Wang F, Wang X, Zhong L, Duan T, Wu Y, Cao J, Tang J, Sang Y, Wang L, Lv X, Xu S, Zhang RH, Deng WG, Li SP, Zeng YX, Kang T., Free PMC Article | 01/24/2015 |
| These results suggested that BRD7 acts as a tumor suppressor in epithelial ovarian cancers | Tumor suppressive effects of bromodomain-containing protein 7 (BRD7) in epithelial ovarian carcinoma.
Park YA, Lee JW, Kim HS, Lee YY, Kim TJ, Choi CH, Choi JJ, Jeon HK, Cho YJ, Ryu JY, Kim BG, Bae DS. | 10/11/2014 |
| Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. | Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
Tang H, Wang Z, Liu Q, Liu X, Wu M, Li G., Free PMC Article | 09/20/2014 |
| BRD7-mediated translocation of a subfraction (but not all) of the p85 protein to the nucleus could enhance PI3K signaling. | BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.
Chiu YH, Lee JY, Cantley LC., Free PMC Article | 05/31/2014 |
| No evidence for breast cancer susceptibility is associated with variants of BRD7. | No evidence for breast cancer susceptibility associated with variants of BRD7, a component of p53 and BRCA1 pathways.
Penkert J, Schlegelberger B, Steinemann D, Gadzicki D. | 04/27/2013 |
| Data show a substantial proportion of germ-line mutations in triple-negative breast cancer (TNBC), with a preponderance of BRCA1 mutations over mutations in BRCA2 or PALB2, but no evidence to implicate BRD7 mutations in the etiology of TNBC. | Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.
Pern F, Bogdanova N, Schürmann P, Lin M, Ay A, Länger F, Hillemanns P, Christiansen H, Park-Simon TW, Dörk T., Free PMC Article | 04/6/2013 |