| Knockdown of calpain1 in lumbar motoneurons reduces spasticity after spinal cord injury in adult rats. | Knockdown of calpain1 in lumbar motoneurons reduces spasticity after spinal cord injury in adult rats.
Kerzonkuf M, Verneuil J, Brocard C, Dingu N, Trouplin V, Ramirez Franco JJ, Bartoli M, Brocard F, Bras H., Free PMC Article | 04/11/2024 |
| Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p. | Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
Xue X, Xi W, Li W, Xiao J, Wang Z, Zhang Y., Free PMC Article | 10/13/2023 |
| MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA. | MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA.
Zhang Y, Zhang J, Sun Z, Wang H, Ning R, Xu L, Zhao Y, Yang K, Xi X, Tian J., Free PMC Article | 06/24/2023 |
| Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6. | Exercise improves the body function and protects the neuronal injury in Parkinson's disease rats by activating calpain 1 and kallikrein 6.
Guo J, Yang J, Fu J, Tripathi A. | 12/10/2022 |
| Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. | Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease.
Zaman V, Drasites KP, Myatich A, Shams R, Shields DC, Matzelle D, Haque A, Banik NL., Free PMC Article | 12/10/2022 |
| LXR activation ameliorates high glucose stress-induced aberrant mitochondrial dynamics via downregulation of Calpain1 expression in H9c2 cardiomyoblasts. | LXR activation ameliorates high glucose stress-induced aberrant mitochondrial dynamics via downregulation of Calpain1 expression in H9c2 cardiomyoblasts.
Lin J, Wang F, Jiang G, Zhang T, Zhang J, He Q, Fan Y. | 06/18/2022 |
| elevated ammonia level may induce neuronal dysfunction via abnormal calcium influx and calpain-dependent CRMP-2 cleavage | Ammonia induces calpain-dependent cleavage of CRMP-2 during neurite degeneration in primary cultured neurons.
Cai Z, Zhu X, Zhang G, Wu F, Lin H, Tan M., Free PMC Article | 07/25/2020 |
| In sum, by up- and down-regulating the persistent sodium current and KCC2, the calpain-mediated proteolysis of voltage-gated sodium (Nav) channels and KCC2 drives the hyperexcitability of motoneurons which leads to spasticity after spasticity after spinal cord injury. | Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity.
Plantier V, Sanchez-Brualla I, Dingu N, Brocard C, Liabeuf S, Gackière F, Brocard F., Free PMC Article | 05/30/2020 |
| The data support a link between Parkin phosphorylation and its cleavage by calpain. | Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer(65)Parkin reducing its calpain-cleavage.
Wang H, Cheung F, Stoll AC, Rockwell P, Figueiredo-Pereira ME., Free PMC Article | 02/8/2020 |
| Study found that the number of spontaneous seizures detected prior to sample collection was correlated with altered calpain activity and expression. | Calpain activation and neuronal death during early epileptogenesis.
Lam PM, González MI., Free PMC Article | 12/28/2019 |
| Results implicate calpain-2 in the Ca2+-dependent regulation of extrasynaptic NMDARs and calpain-1 in the Ca2+-dependent regulation of synaptic NMDARs in substantia nigra pars compacta-dopaminergic neurons during the first postnatal week and suggest that these roles of calpain-1 and calpain-2 are developmentally regulated. | Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons.
Zhao J, Baudry M, Jones S. | 02/23/2019 |
| The protective effect of oxytocin in ischemic stroke may be associated with calpain-1-dependent mechanisms. | Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1.
Etehadi Moghadam S, Azami Tameh A, Vahidinia Z, Atlasi MA, Hassani Bafrani H, Naderian H. | 07/28/2018 |
| inhibition of pathological micro-calpain activation may present an interesting novel drug target in the treatment of postherpetic neuralgia. | Activation and expression of μ-calpain in dorsal root contributes to RTX-induced mechanical allodynia.
Yuan XC, Wu CH, Gao F, Li HP, Xiang HC, Zhu H, Pan XL, Lin LX, Liu YS, Yu W, Tian B, Meng XF, Li M., Free PMC Article | 05/5/2018 |
| the present study demonstrated that in rats with hypoxic-ischemic brain damage , there is a positive correlation between increased apoptosis of myocardial cells and expression levels of calpain-1 and caspase-3. | Association between myocardial cell apoptosis and calpain-1/caspase-3 expression in rats with hypoxic-ischemic brain damage.
Zhao H, Xu M, Chu G. | 02/17/2018 |
| Results indicate that calpain-1 and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 and CA3, and triggers neurodegenerative cascades. | Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
Seinfeld J, Baudry N, Xu X, Bi X, Baudry M., Free PMC Article | 10/28/2017 |
| Our findings indicate that calpain-GRIP signaling is essential for the restabilization process that is associated with drug cue memory and the inhibition of calpain activity may be a novel strategy for the prevention of drug relapse. | Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory.
Liang J, Li JL, Han Y, Luo YX, Xue YX, Zhang Y, Zhang Y, Zhang LB, Chen ML, Lu L, Shi J., Free PMC Article | 09/30/2017 |
| In conclusion, our data provide evidence that damage to membrane skeleton proteins via calpain is a destructive downstream event of CaMKII activation in the setting of myocardial IR injury. | CaMKII inhibition mitigates ischemia/reperfusion-elicited calpain activation and the damage to membrane skeleton proteins in isolated rat hearts.
Kong LH, Gu XM, Wu F, Jin ZX, Zhou JJ. | 09/16/2017 |
| Our results are supportive of the hypothesis that suppression of calpain expression leading to slowing of cell migration is a potential mechanism through which NSAIDs cause GI toxicity. | Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum.
Silver K, Littlejohn A, Thomas L, Bawa B, Lillich JD., Free PMC Article | 06/24/2017 |
| hese results suggest that the protein adjustments observed in lipid raft/caveolin-1 microdomains could be visualized as a process required to protect the cells against NO overproduction and aberrant calpain activation. Alterations in eNOS, calpain-1 and HSP90 levels have been observed in aorta of Zucker Diabetic Rats (ZDR). | Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Martines A, Stifanese R, Faelli EL, Perasso L, Melloni I, Ruggeri P, Averna M. | 02/4/2017 |
| Cytoplasmic and nuclear immunostaining for bax, caspase-3, calpain-1 and survivin proteins were found in the endometrial epithelium and stromal cells. | Involution dependent changes in distribution and localization of bax, survivin, caspase-3, and calpain-1 in the rat endometrium.
Alan E, Liman N. | 12/24/2016 |
| This study demonstrates that Nav channel expression in lumbar motoneurons is altered after SCI, and it shows a tight relationship between the calpain-dependent proteolysis of Nav1.6 channels, the upregulation of I(NaP) and spastici | Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury.
Brocard C, Plantier V, Boulenguez P, Liabeuf S, Bouhadfane M, Viallat-Lieutaud A, Vinay L, Brocard F. | 08/27/2016 |
| Our results indicate that low calpain activity, due to absence of calpain 1 and degradation of calpain 2, results in a preference for ACD over apoptosis in insulin-deprived HCN cells | Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal.
Chung KM, Park H, Jung S, Ha S, Yoo SJ, Woo H, Lee HJ, Kim SW, Kim EK, Moon C, Yu SW. | 07/16/2016 |
| Calpain-1 activation plays critical role in vascular calcification caused by oxidized low density lipoprotein, which might be mediated by pyrophosphate metabolism disorder. | Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
Tang F, Chan E, Lu M, Zhang X, Dai C, Mei M, Zhang S, Wang H, Song Q., Free PMC Article | 03/26/2016 |
| alphaB-crystallin has a role in controlling FAK function and cardiomyocyte survival through the prevention of calpain-mediated degradation of FAK | αB-crystallin interacts with and prevents stress-activated proteolysis of focal adhesion kinase by calpain in cardiomyocytes.
Pereira MB, Santos AM, Gonçalves DC, Cardoso AC, Consonni SR, Gozzo FC, Oliveira PS, Pereira AH, Figueiredo AR, Tiroli-Cepeda AO, Ramos CH, de Thomaz AA, Cesar CL, Franchini KG. | 02/27/2016 |
| Manganese induces the cleavage of alpha-synuclein protein via overactivation of calpain and subsequent alpha-synuclein oligomerization. | Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures.
Xu B, Liu W, Deng Y, Yang TY, Feng S, Xu ZF., Free PMC Article | 01/16/2016 |