| Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation. | Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO(3) Stimulation.
Zhang S, Qiu Y, Feng Y, Zhang Y, Li Y, Wang B, Wei H, Chen X, Shen L, Li W, Zheng L, Zhang Y., Free PMC Article | 02/4/2023 |
| m-Calpain is released from striatal synaptosomes. | m-Calpain is released from striatal synaptosomes.
Pestereva N, Ivleva I, Zubov A, Tikhomirova M, Karpenko M. | 02/4/2023 |
| Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. | Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease.
Zaman V, Drasites KP, Myatich A, Shams R, Shields DC, Matzelle D, Haque A, Banik NL., Free PMC Article | 12/10/2022 |
| MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2. | MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2.
Ge XY, Zhu TT, Yao MZ, Liu H, Wu Q, Qiao J, Zhang WF, Hu CP., Free PMC Article | 10/2/2021 |
| Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation. | Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation.
Wang H, Yu Q, Zhang ZL, Ma H, Li XQ., Free PMC Article | 09/11/2021 |
| Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.
Wang WY, Xie L, Zou XS, Li N, Yang YG, Wu ZJ, Tian XY, Zhao GY, Chen MH. | 06/5/2021 |
| We found that the number of spontaneous seizures detected prior to sample collection was correlated with altered calpain activity and expression | Calpain activation and neuronal death during early epileptogenesis.
Lam PM, González MI., Free PMC Article | 12/28/2019 |
| The calcium-activated neutral protease-2 (calpain-2) was a direct target gene of miR-137-3p with miR-137-3p binding to the 3'-untranslated region of calpain-2. Silencing of calpain-2 suppressed the expression of neuronal nitric oxide synthase (nNOS), a primary source of nitric oxide (NO). | MiR-137-3p rescue motoneuron death by targeting calpain-2.
Tang Y, Fu R, Ling ZM, Liu LL, Yu GY, Li W, Fang XY, Zhu Z, Wu WT, Zhou LH. | 04/6/2019 |
| Within 24h following L5 ventral root transection (L5-VRT) model injury observed robust elevation of CALP2 and TNF-alpha in bilateral dorsal root ganglias (DRGs) and bilateral spinal cord neurons. CALP2 and TNF-alpha protein induction by L5-VRT were significantly inhibited by pretreatment using the calpain inhibitor MDL28170. | Calpain-2 Regulates TNF-α Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Chen SX, Liao GJ, Yao PW, Wang SK, Li YY, Zeng WA, Liu XG, Zang Y. | 02/23/2019 |
| Results implicate calpain-2 in the Ca2+-dependent regulation of extrasynaptic NMDARs and calpain-1 in the Ca2+-dependent regulation of synaptic NMDARs in substantia nigra pars compacta-dopaminergic neurons during the first postnatal week and suggest that these roles of calpain-1 and calpain-2 are developmentally regulated. | Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons.
Zhao J, Baudry M, Jones S. | 02/23/2019 |
| Results indicate that calpain-1 and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 and CA3, and triggers neurodegenerative cascades. | Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
Seinfeld J, Baudry N, Xu X, Bi X, Baudry M., Free PMC Article | 10/28/2017 |
| Hippocampal calpain-2/p35-p25/Cdk5 pathway was involved in BDE-153-induced neuronal apoptosis. | Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153.
Zhang H, Chang L, Zhang H, Nie J, Zhang Z, Yang X, Vuong AM, Wang Z, Chen A, Niu Q. | 08/12/2017 |
| Our results are supportive of the hypothesis that suppression of calpain expression leading to slowing of cell migration is a potential mechanism through which NSAIDs cause GI toxicity. | Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum.
Silver K, Littlejohn A, Thomas L, Bawa B, Lillich JD., Free PMC Article | 06/24/2017 |
| Our results indicate that low calpain activity, due to absence of calpain 1 and degradation of calpain 2, results in a preference for ACD over apoptosis in insulin-deprived HCN cells | Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal.
Chung KM, Park H, Jung S, Ha S, Yoo SJ, Woo H, Lee HJ, Kim SW, Kim EK, Moon C, Yu SW. | 07/16/2016 |
| ISO increased NOXs-derived ROS which activated nuclear translocation of calpain-2, subsequently nuclear calpain-2 degraded CaMK II dB which reduced the ratio of Bcl-2 to Bax and mitochondria apoptosis pathway was triggered in rat cardiomyocytes | ROS-Induced Nuclear Translocation of Calpain-2 Facilitates Cardiomyocyte Apoptosis in Tail-Suspended Rats.
Chang H, Sheng JJ, Zhang L, Yue ZJ, Jiao B, Li JS, Yu ZB. | 06/4/2016 |
| Results revealed that betaII-spectrin was degraded into major fragments of 110/85 kDa by calpain-2 activation and 108/80 kDa by caspase-3 activation. | Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Kobeissy FH, Liu MC, Yang Z, Zhang Z, Zheng W, Glushakova O, Mondello S, Anagli J, Hayes RL, Wang KK., Free PMC Article | 05/21/2016 |
| hypertrophied cardiomyocytes show increased susceptibility to apoptosis during Ang II stimulation via nuclear calpain-2 and CaMKIIdeltaB pathway. | Nuclear Translocation of Calpain-2 Mediates Apoptosis of Hypertrophied Cardiomyocytes in Transverse Aortic Constriction Rat.
Sheng JJ, Chang H, Yu ZB. | 10/17/2015 |
| Early increase of calpain-2 in L5-ventral root transection rats might be responsible for the induction of allodynia via up-regulating IL-6 in DRG neurons. | Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Zang Y, Chen SX, Liao GJ, Zhu HQ, Wei XH, Cui Y, Na XD, Pang RP, Xin WJ, Zhou LJ, Liu XG. | 08/15/2015 |
| the present study suggests a role for calpain 2 in the disassembly of focal adhesions, which has been previously shown to play a key role in uterine receptivity for implantation | Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites.
Kaneko Y, Murphy CR, Day ML. | 02/7/2015 |
| The findings also suggest that calpain may be involved in the execution phase of apoptosis | Calpain mediates caspase-dependent apoptosis initiated by hydrogen peroxide in pancreatic acinar AR42J cells.
Weber H, Müller L, Jonas L, Schult C, Sparmann G, Schuff-Werner P. | 11/2/2013 |
| the activation of the calpain 2/p35-p25/Cdk5 signaling pathway may contribute to glutamate neurotoxicity in the retina by up-regulating p-NR2A(S1232) expression. | Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons.
Miao Y, Dong LD, Chen J, Hu XC, Yang XL, Wang Z., Free PMC Article | 02/23/2013 |
| Calpain-2 expression was slightly decreased, whereas calpain-1 expression was unaltered in tail-suspended rats. | [Calpain mediates cardiac troponin I degradation in tail-suspended rats].
Xu PT, Song Z, Li Q, Zhang L, Wang YY, Yu ZB. | 02/2/2013 |
| passive stretch on soleus muscles may prevent in part unloading-induced atrophy through a calpain signal pathway | Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles.
Xu PT, Li Q, Sheng JJ, Chang H, Song Z, Yu ZB. | 10/20/2012 |
| cleavage of CPEB3 by NMDA-activated calpain 2 accounts for the activity-related translation of CPEB3-targeted RNAs | Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
Wang CF, Huang YS., Free PMC Article | 10/20/2012 |
| Data show that m-Calpain small subunit does not dissociate from the large subunit, but is proteolyzed to a 40-45k heterodimer of Domains IV and VI. | m-Calpain activation in vitro does not require autolysis or subunit dissociation.
Chou JS, Impens F, Gevaert K, Davies PL. | 08/13/2011 |