| Role of NOD2 and hepcidin in inflammatory periapical periodontitis. | Role of NOD2 and hepcidin in inflammatory periapical periodontitis.
Hu J, Dusenge MA, Ye Q, Zhao YQ, Tan L, Feng Y, Zhao J, Gao ZR, Zhang SH, Chen Y, Zhou YH, Guo Y, Feng YZ., Free PMC Article | 07/9/2022 |
| Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. | Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes.
Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC., Free PMC Article | 01/8/2022 |
| Data show that mRNA expression and protein levels of nucleotide-binding oligomerization domain-containing proteins (NOD1, NOD2) and NLR family, pyrin domain containing 3 protein (NLRP3) were significantly increased in the severe acute pancreatitis (SAP) models. | Involvement of Nucleotide-Binding and Oligomerization Domain-Like Receptors in the Intestinal Injury of Severe Acute Pancreatitis in Rats.
Xu S, Wei S, Guo Y, Cui D, Yao J. | 10/6/2018 |
| NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression. | NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells.
Layunta E, Latorre E, Forcén R, Grasa L, Castro M, Arias MA, Alcalde AI, Mesonero JE. | 08/18/2018 |
| in rat peritoneal mast cells the ingested cargo can, through interruptions of the phagosome membrane, interact directly with NOD1 and NOD2 proteins, which act as switches in the process of cytokine production. | NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence.
Zabucchi G, Trevisan E, Vita F, Soranzo MR, Borelli V. | 02/20/2016 |
| Nod2-Rip2-NFkappaB signaling involved in the small intestinal inflammatory injury caused by muramyl dipeptide which is transported through PepT1. | Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats.
Ma G, Shi B, Liu J, Zhang H, YinTao Z, Lou X, Liang D, Hou Y, Wan S, Yang W. | 02/6/2016 |
| Mammary innate immune responses were activated after Staphylococcus aureus inoculation. TLR2, NOD2, and inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, CXCL1, IL-10, TGF-beta1, and IFN-gamma) are involved in the response to mastitis induced by S. aureus. | Characterization of TLR2, NOD2, and related cytokines in mammary glands infected by Staphylococcus aureus in a rat model.
Wang H, Yu G, Yu H, Gu M, Zhang J, Meng X, Liu Z, Qiu C, Li J., Free PMC Article | 02/6/2016 |
| studies demonstrate that HuR acts as a key posttranscriptional regulator of NOD2 expression, suggesting that targeting of HuR-NOD2 signaling might be crucial for the treatment of DN | Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy.
Shang J, Wan Q, Wang X, Duan Y, Wang Z, Wei X, Zhang Y, Wang H, Wang R, Yi F. | 01/16/2016 |
| NOD2 triggering induces CD4 antigen-negative dendritic cells to mature and produce high levels of interleukin (IL)-12p40, low levels of IL-10, and tumor necrosis factor-alpha. | Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets.
Hubert FX, Voisine C, Louvet C, Heslan JM, Ouabed A, Heslan M, Josien R. | 07/28/2011 |
| The NOD2 may play an important role in the up-regulation and activation of NF-kappaB during inflammation reactions in acute pancreatitis. | Expression of NOD2 in a rat model of acute pancreatitis.
Qian M, Fang L, Cui Y. | 01/15/2011 |
| These results show that NOD2 alone is capable of acutely inducing insulin resistance within muscle cells, possibly by activating endogenous inflammatory signals and/or through cytokine production, curbing upstream insulin signals. | NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance.
Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, Philpott DJ, Klip A. | 01/8/2011 |
| These results suggest that intestinal I/R increases the infiltration of DCs into the small intestine, thus potentially involving the upregulation of NOD2, HMGB1, and TLR4 | Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine.
Hagiwara S, Iwasaka H, Hasegawa A, Asai N, Uchida T, Noguchi T. | 07/19/2010 |
| TLR-2, TLR-4, NOD2 and pNF-kappaB areexpressed in a neonatal rat model of necrotizing enterocolitis | Expression of TLR-2, TLR-4, NOD2 and pNF-kappaB in a neonatal rat model of necrotizing enterocolitis.
Le Mandat Schultz A, Bonnard A, Barreau F, Aigrain Y, Pierre-Louis C, Berrebi D, Peuchmaur M., Free PMC Article | 01/21/2010 |
| results suggest that in addition to the TLR recognition systems, Card15/Nod2 may contribute to the inflammatory process not only in the epithelial and submucosal layers but also in the tunica muscularis. | Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats.
Fujisawa M, Kiyosue M, Hori M, Ozaki H. | 01/21/2010 |