| Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia. | Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia.
Takano-Kawabe K, Matoba K, Nakamura Y, Moriyama M. | 01/10/2024 |
| Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. | Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.
Kulkarni K, Patel S, Ali R, Hussain T., Free PMC Article | 03/22/2023 |
| Megalin: A Novel Endocytic Receptor for Prorenin and Renin. | Megalin: A Novel Endocytic Receptor for Prorenin and Renin.
Sun Y, Goes Martini A, Janssen MJ, Garrelds IM, Masereeuw R, Lu X, Danser AHJ. | 04/13/2021 |
| Renal megalin expression was found to be upregulated in early type 2 diabetic rats in a process that may involve high glucose and insulin in a PI3K/Akt-dependent manner. | Increased megalin expression in early type 2 diabetes: role of insulin-signaling pathways.
Bryniarski MA, Yee BM, Jaffri I, Chaves LD, Yu JA, Guan X, Ghavam N, Yacoub R, Morris ME. | 09/21/2019 |
| Mild oxidative stress increases renal megalin expression through the phosphatidylinositol 3-kinase-Akt pathway in the normoalbuminuric stage of diabetes mellitus. | Oxidative stress increases megalin expression in the renal proximal tubules during the normoalbuminuric stage of diabetes mellitus.
Kurosaki Y, Imoto A, Kawakami F, Yokoba M, Takenaka T, Ichikawa T, Katagiri M, Ishii N. | 05/4/2019 |
| Data suggest that, in acute kidney injury (here, due to cadmium poisoning), kidney exhibits down-regulation of megalin receptor activity; up-regulation of NFkappaB, TLR2 (toll like receptor-2), and TLR4 (toll like receptor-4); and significant reduction in GSH (glutathione). | Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats.
Elshaer SS, Anwar HM. | 06/16/2018 |
| Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules. | Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy.
De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A. | 08/19/2017 |
| Data suggest both LRP1 and LRP2 are necessary in growth cones for ligand- (zinc metallothionein IIa-)mediated chemotactic calcium-dependent signal transduction in sensory neurons, for axon guidance/neurogenesis, and for peripheral nerve regeneration. | Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration.
Landowski LM, Pavez M, Brown LS, Gasperini R, Taylor BV, West AK, Foa L., Free PMC Article | 06/4/2016 |
| Megalin-mediated B12 endocytosis in renal tubules may be regulated by methylmalonic acid. | Elevation of urinary methylmolonic acid induces the suppression of megalin-mediated endocytotic cycles during vitamin B12 deficiency.
Shiga T, Kawata T, Furusho T, Tadokoro T, Suzuki T, Yamamoto Y. | 11/14/2015 |
| The inhibition of megalin/cubilin or lysosomal cathepsin B reduced albuminuria-induced NLRP3 inflammasome activation. | Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC., Free PMC Article | 10/17/2015 |
| ARH knockdown leads to fast recycling of megalin via a Rab35 pathway. | ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Shah M, Baterina OY Jr, Taupin V, Farquhar MG., Free PMC Article | 09/14/2013 |
| Dietary resistant starch normalized megalin and Dab2 mRNA overexpression in diabetic rats. | Dietary resistant starch prevents urinary excretion of 25-hydroxycholecalciferol and vitamin D-binding protein in type 1 diabetic rats.
Smazal AL, Borcherding NC, Anderegg AS, Schalinske KL, Whitley EM, Rowling MJ. | 08/31/2013 |
| megalin-dependent endocytosis has a role along the proximal nephron in the intrarenal renin angiotensin system | Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F., Free PMC Article | 02/26/2011 |
| NMHC-IIA is functionally linked to megalin by interaction with Dab2 and is likely involved in megalin-mediated endocytosis in proximal tubule cells. | Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.
Hosaka K, Takeda T, Iino N, Hosojima M, Sato H, Kaseda R, Yamamoto K, Kobayashi A, Gejyo F, Saito A. | 01/21/2010 |
| cubilin and megalin constitute a dual-receptor complex facilitating the function of each other in the inner ear | Cubilin and megalin co-localize in the neonatal inner ear.
Tauris J, Christensen EI, Nykjaer A, Jacobsen C, Petersen CM, Ovesen T. | 01/21/2010 |
| There is AT(1A)R- and insulin-mediated competitive signaling cross talk to regulate megalin expression in cultured proximal tubule cells. | Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk.
Hosojima M, Sato H, Yamamoto K, Kaseda R, Soma T, Kobayashi A, Suzuki A, Kabasawa H, Takeyama A, Ikuyama K, Iino N, Nishiyama A, Thekkumkara TJ, Takeda T, Suzuki Y, Gejyo F, Saito A. | 01/21/2010 |
| Astrocytes express megalin, an endocytic receptor for multiple ligands including albumin; megalin is required for albumin binding and internalization in the astrocyte. | Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid.
Bento-Abreu A, Velasco A, Polo-Hernández E, Pérez-Reyes PL, Tabernero A, Medina JM. | 01/21/2010 |
| The present data indicate that leptin represents a novel megalin ligand of importance in the levels and therapeutic actions of leptin into the brain. | Megalin mediates the transport of leptin across the blood-CSF barrier.
Dietrich MO, Spuch C, Antequera D, Rodal I, de Yébenes JG, Molina JA, Bermejo F, Carro E. | 01/21/2010 |
| Three distinct regions of cubilin bind to megalin and its interactions with both megalin and amnionless are essential for its intracellular stability. | Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability.
Ahuja R, Yammani R, Bauer JA, Kalra S, Seetharam S, Seetharam B. | 01/21/2010 |
| Significant amounts of megalin and cubilin were present in the glomerular cells in addition to the proximal tubular cells. The quantity of these receptors progressively increased in the glomerulus with age. | Age-related change of endocytic receptors megalin and cubilin in the kidney in rats.
Odera K, Goto S, Takahashi R. | 01/21/2010 |
| Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease | Early changes in gene expression that influence the course of primary glomerular disease.
Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C, Chugh SS. | 01/21/2010 |
| Megalin is an endocytic receptor that binds multiple ligands and is essential for many physiological processes such as brain development | The adaptor protein ARH escorts megalin to and through endosomes.
Nagai M, Meerloo T, Takeda T, Farquhar MG., Free PMC Article | 01/21/2010 |
| The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns. | Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.
Wolf CA, Dancea F, Shi M, Bade-Noskova V, Rüterjans H, Kerjaschki D, Lücke C. | 01/21/2010 |
| megalin has a role in thyroid homeostasis with possible implications in thyroid diseases | Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release.
Lisi S, Pinchera A, McCluskey RT, Willnow TE, Refetoff S, Marcocci C, Vitti P, Menconi F, Grasso L, Luchetti F, Collins AB, Marino M., Free PMC Article | 01/21/2010 |
| Coordinated and reciprocal alterations of the increase in CYP27B1 mRNA and the decrease in CYP24 mRNA may play a pivotal role in maintaining the plasma level of 1 alpha,25(OH)2D3 in the face of reduced nephron mass and/or megalin expression. | Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats.
Takemoto F, Shinki T, Yokoyama K, Inokami T, Hara S, Yamada A, Kurokawa K, Uchida S. | 01/21/2010 |