| Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin. | Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
Merce AP, Ionică LN, Bînă AM, Popescu S, Lighezan R, Petrescu L, Borza C, Sturza A, Muntean DM, Creţu OM. | 01/21/2023 |
| The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety. | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
Tseilikman V, Lapshin M, Klebanov I, Chrousos G, Vasilieva M, Pashkov A, Fedotova J, Tseilikman D, Shatilov V, Manukhina E, Tseilikman O, Sarapultsev A, Downey HF., Free PMC Article | 05/21/2022 |
| Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis. | Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Cho HU, Kim S, Sim J, Yang S, An H, Nam MH, Jang DP, Lee CJ., Free PMC Article | 04/2/2022 |
| Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension. | Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension.
Sun XQ, Peters EL, Schalij I, Axelsen JB, Andersen S, Kurakula K, Gomez-Puerto MC, Szulcek R, Pan X, da Silva Goncalves Bos D, Schiepers REJ, Andersen A, Goumans MJ, Vonk Noordegraaf A, van der Laarse WJ, de Man FS, Bogaard HJ. | 03/28/2021 |
| MAO-A is induced in diabetic aortas and vitamin D can improve diabetes-induced endothelial dysfunction by modulating the MAO-A expression. | Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes.
Sturza A, Văduva A, Uțu D, Rațiu C, Pop N, Duicu O, Popoiu C, Boia E, Matusz P, Muntean DM, Olariu S. | 03/2/2019 |
| Acute alcohol withdrawal was associated with elevated MAO-A levels and activity in the brain. | Elevated monoamine oxidase A activity and protein levels in rodent brain during acute withdrawal after chronic intermittent ethanol vapor exposure.
Matthews BA, Tong J, Attwells S, Xu X, Le A, Kish SJ, Meyer JH. | 09/22/2018 |
| These results suggest that the inhibition of Sirt1/MAO-A expression in astrocytes in the prefrontal cortex may contribute to the different anti-depressive effects of Repetitive transcranial magnetic stimulation with different parameters, and may also provide a novel insight into the mechanisms underlying major depressive disorder. | Repetitive transcranial magnetic stimulation inhibits Sirt1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes.
Peng ZW, Xue F, Zhou CH, Zhang RG, Wang Y, Liu L, Sang HF, Wang HN, Tan QR. | 07/14/2018 |
| Extensive SAR studies and in vivo behavioral evaluations of this and other related analogue series identified a number of potential clinical development candidates; ultimately, compound 8f was identified as a candidate molecule with high selectivity toward MAO-B (29-56 nM) over MAO-A (19% inhibition at a screening concentration of 50 muM), an excellent profile against a panel of other enzymes and receptors, good pharma... | Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition.
Kaplan AP, Keenan T, Scott R, Zhou X, Bourchouladze R, McRiner AJ, Wilson ME, Romashko D, Miller R, Bletsch M, Anderson G, Stanley J, Zhang A, Lee D, Nikpur J. | 02/3/2018 |
| Amine oxidases are important mediators of pathological processes of rhabdomyolysis in rats. | Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats.
Gudkova OO, Latyshko NV, Shandrenko SG. | 01/20/2018 |
| Consequently, MAO activities in a brain and a liver depend on the microsomal oxidation process. | The role of microsomal oxidation in the regulation of monoamine oxidase activity in the brain and liver of rats.
Kozochkin DA, Manukhina EB, Downey HF, Tseilikman OB, Komelkova MV, Vasilyeva MV, Lapshin MS, Sahabutdinov MN, Lazuko SS, Tseilikman VE. | 11/25/2017 |
| Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm | A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.
Huang G, Zhu F, Chen Y, Chen S, Liu Z, Li X, Gan L, Zhang L, Yu Y. | 05/13/2017 |
| this study provides strong evidence that MAO-A is an important source of oxidative stress in the heart and that MAO-A-derived reactive oxygen species contribute to diabetic cardiomyopathy. | Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy.
Umbarkar P, Singh S, Arkat S, Bodhankar SL, Lohidasan S, Sitasawad SL. | 08/6/2016 |
| Growing evidence suggests that the monoamine oxidase A (MAOA) gene, which codes for MAOA, plays an important role in regulating behavior and is linked with impulsivity, stress-related disorders and AUD. | Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation.
Bendre M, Comasco E, Nylander I, Nilsson KW., Free PMC Article | 07/30/2016 |
| In conclusion, data obtained in this study showed a correlation between MAO activity and microsomal oxidation phenotype. | Duration of hexobarbital-induced sleep and monoamine oxidase activities in rat brain: Focus on the behavioral activity and on the free-radical oxidation.
Tseilikman VE, Kozochkin DA, Manukhina EB, Downey HF, Tseilikman OB, Misharina ME, Nikitina AA, Komelkova MV, Lapshin MS, Kondashevskaya MV, Lazuko SS, Kusina OV, Sahabutdinov MV. | 07/16/2016 |
| results demonstrate that selective MAO-A inhibition with pirlindole is able to revert the behavioural effects of stress exposure while promoting hippocampal adult neurogenesis and rescuing the stress-induced dendritic atrophy of granule neurons. | The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
Morais M, Santos PA, Mateus-Pinheiro A, Patrício P, Pinto L, Sousa N, Pedroso P, Almeida S, Filipe A, Bessa JM. | 12/26/2015 |
| Under conditions of chronic hemodynamic stress, enhanced MAO-B activity is a major determinant of cardiac structural and functional disarrangement. | Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.
Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N., Free PMC Article | 08/16/2014 |
| Peripubertally stressed rats showed increased MAOA mRNA levels in the pre-frontal cortex. | Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Márquez C, Poirier GL, Cordero MI, Larsen MH, Groner A, Marquis J, Magistretti PJ, Trono D, Sandi C., Free PMC Article | 07/6/2013 |
| MAO-A upregulation in the heart causes oxidative mitochondrial damage, p53-dependent repression of PGC-1alpha, cardiomyocyte necrosis, and chronic ventricular dysfunction. | p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.
Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J., Free PMC Article | 05/18/2013 |
| A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells. | Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
Liu YJ, Meng FT, Wang LL, Zhang LF, Cheng XP, Zhou JN. | 10/20/2012 |
| Rat MAO A exhibits functional properties similar but not identical with those of the human enzyme, providing additional support for C-H bond cleavage via a polar nucleophilic mechanism | ²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.
Wang J, Edmondson DE., Free PMC Article | 10/22/2011 |
| investigation of topological orientation of MAO-A (and MAO-B) in liver mitochondrial membranes | Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
Wang J, Edmondson DE., Free PMC Article | 06/4/2011 |
| Although approximately 90% identical in sequence to human MAO A, rat MAO A is a more efficient catalyst for amine neurotransmitter oxidation. | High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A.
Wang J, Edmondson DE., Free PMC Article | 05/31/2010 |
| significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex | Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
Meyers B, D'Agostino A, Walker J, Kritzer MF., Free PMC Article | 03/15/2010 |
| Principal component analysis points to the three domains that define MaoA's global dynamics. A pronounced anticorrelation exists in the motions of MaoA domain M relative to domains S and F in the membrane-bound compared to the membrane-unbound system. | Membrane attachment facilitates ligand access to the active site in monoamine oxidase A.
Apostolov R, Yonezawa Y, Standley DM, Kikugawa G, Takano Y, Nakamura H. | 01/21/2010 |
| These data suggest that the structural properties of the active site cavities in rat MAOs are significantly different from the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs. | Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms.
Upadhyay AK, Wang J, Edmondson DE. | 01/21/2010 |