| Negative relationship between brain alpha1A-AR neurotransmission and betaArr2 levels in anxious adolescent rats subjected to early life stress. | Negative relationship between brain α(1A)-AR neurotransmission and βArr2 levels in anxious adolescent rats subjected to early life stress.
Mahmoodkhani M, Amini M, Derafshpour L, Ghasemi M, Mehranfard N. | 08/7/2021 |
| Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors. | Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors.
Romero-Imbachi MR, Cupitra N, Ángel K, González B, Estrada O, Calderón JC, Guerrero-Vargas J, Beltrán J, Narvaez-Sanchez R. | 07/24/2021 |
| MAPKs Are Highly Abundant but Do Not Contribute to alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period. | MAPKs Are Highly Abundant but Do Not Contribute to α(1)-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period.
Gaynullina DK, Kudryashova TV, Vorotnikov AV, Schubert R, Tarasova OS., Free PMC Article | 07/17/2021 |
| Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro. | Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Chmielarz P, Kuśmierczyk J, Rafa-Zabłocka K, Chorązka K, Kowalska M, Satała G, Nalepa I., Free PMC Article | 07/3/2021 |
| those results suggested NE which stimulated alpha1A -adrenoceptor-mediated the proliferation of pulmonary artery smooth muscle cells (PASMCs), which may be via the CaMKII pathway, and it could be used as a novel treatment strategy in Pulmonary arterial hypertension (PAH). | alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation of pulmonary artery smooth muscle cells via CaMKII signaling.
Luo Q, Wang X, Liu R, Qiao H, Wang P, Jiang C, Zhang Q, Cao Y, Yu H, Qu L. | 07/18/2020 |
| the importance of alpha1A-AR in the peripheral control of ejaculatio | Contraction of Rat Cauda Epididymis Smooth Muscle to α(1)-Adrenoceptor Activation Is Mediated by α(1A)-Adrenoceptors.
Pacini ESA, Castilho ACS, Hebeler-Barbosa F, Pupo AS, Kiguti LRA. | 08/10/2019 |
| Heterologous expression of the alpha1-adrenergic receptors in HEK 293 cell showed accumulation of cAMP in response to phenylephrine in the nucleus and cytoplasm in a GTP-binding proteins-dependent manner. | Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α(1)-adrenergic and ETA endothelin receptors.
Martin RD, Sun Y, Bourque K, Audet N, Inoue A, Tanny JC, Hébert TE. | 06/29/2019 |
| Study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by beta1-adrenoreceptors-autoantibodies (beta1-aabs) and that beta3-adrenoreceptor stimulation blunts the development of beta1-aabs-induced dilated cardiomyopathy. | MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.
Vanhoutte L, Guilbaud C, Martherus R, Bouzin C, Gallez B, Dessy C, Balligand JL, Moniotte S, Feron O., Free PMC Article | 11/10/2018 |
| Chronic stress (water avoidance stress) animals present high levels of urinary noradrenaline, and we find the bladder dysfunctions in these animals are mediated by alpha 1A adrenoceptors, as Silodosin administration prevents the appearance of these alterations. | The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.
Matos R, Serrão P, Rodriguez L, Birder LA, Cruz F, Charrua A. | 05/12/2018 |
| the excitatory input and post-synaptic dynamics of pontine reticular nucleus reticulospinal neurons are indeed intricately modulated by the activation of alpha1- and alpha2-adrenoceptors. | Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus.
Yang N, Qiao QC, Liu YH, Zhang JQ, Hu ZA, Zhang J. | 12/30/2017 |
| effects of female sexual hormones on the expression and function of alpha1A- and alpha1D-adrenoceptor subtypes in the late-pregnant rat myometrium | The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium.
Bóta J, Hajagos-Tóth J, Ducza E, Samavati R, Borsodi A, Benyhe S, Gáspár R. | 09/24/2016 |
| These findings indicated that noradrenaline activates alpha1-adrenoceptors, which were found to be the main receptors in Ca(2+)-related cell homeostasis and protein (including mucin) secretion in rats lacrimal glands. | α1-Adrenoceptors relate Ca(2+) modulation and protein secretions in rat lacrimal gland.
Ikeda-Kurosawa C, Higashio H, Nakano M, Okubo M, Satoh Y, Kurosaka D, Saino T. | 09/24/2016 |
| Silodosin, a selective alpha(1A)-adrenoceptor antagonist, improves voiding behavior in rat models with BOO by inducing recovery of bladder blood flow. | Effect of silodosin, a selective α(1A)-adrenoceptor antagonist, on voiding behavior and bladder blood flow in a rat model of bladder outlet obstruction.
Goi Y, Tomiyama Y, Yokoyama A, Tatemichi S, Maruyama K, Kobayashi M, Yamaguchi O. | 07/30/2016 |
| Within 2 weeks of a burn, Adra1 expression increased in the re-forming epidermis, in dense bands of spindle-shaped cells in the upper dermis and on nerve fibres in the deep dermis. Adra1 expression in the upper dermis decreased contralateral to the burn. | Up-regulation of cutaneous α1-adrenoceptors after a burn.
Drummond PD, Dawson LF, Finch PM, Drummond ES, Wood FM, Fear MW. | 06/28/2016 |
| The experiments suggest that in the SHR but not the WKY aorta, alpha1 -adrenoceptor activation desensitizes TP receptors through activation of PKC-epsilon. | α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
Zhao Y, Vanhoutte PM, Leung SW., Free PMC Article | 05/21/2016 |
| CXCR4 and ACKR3 modulate alpha1-AR reactivity in vascular smooth muscle and regulate hemodynamics in normal and pathological conditions | Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function.
Bach HH 4th, Wong YM, Tripathi A, Nevins AM, Gamelli RL, Volkman BF, Byron KL, Majetschak M., Free PMC Article | 12/12/2015 |
| Our data suggest that PKCalpha, beta and epsilon activation may underlie physiological and pathophysiological responses of alpha1-AR signaling for the phosphorylation of membrane-associated substrates including ion-channel and transporter proteins. | Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.
O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM., Free PMC Article | 11/28/2015 |
| heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction | Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 06/27/2015 |
| Data suggest an important role of alpha1 adrenoceptor autoimmunity in the pathogenesis and management of hypertension especially in those harboring high alpha1-AA levels. | Enhanced vasoconstriction to α1 adrenoceptor autoantibody in spontaneously hypertensive rats.
Yan L, Tan X, Chen W, Zhu H, Cao J, Liu H. | 04/25/2015 |
| In conclusion, Gq protein-coupled alpha1 adrenergic receptors evoke pMF, but they are not necessary for AIH-induced pLTF. | Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation.
Huxtable AG, MacFarlane PM, Vinit S, Nichols NL, Dale EA, Mitchell GS., Free PMC Article | 01/24/2015 |
| Data indicate that co-expression of alpha1A- and alpha2A-adrenoceptor in the same neuron was observed in normal DRG and increased post chronic constriction injury of sciatic nerve (CCI). | Differential expression of alpha-adrenoceptor subtypes in rat dorsal root ganglion after chronic constriction injury.
Cheng HJ, Ma KT, Li L, Zhao L, Wang Y, Si JQ. | 10/4/2014 |
| Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha1- and alpha2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress. | Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
Alves FH, Crestani CC, Resstel LB, Corrêa FM., Free PMC Article | 09/20/2014 |
| In the frontal cortex during sleep deprivation, adrenergic alpha1 receptor mRNA levels were reduced. | Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system.
Kim Y, Chen L, McCarley RW, Strecker RE., Free PMC Article | 04/12/2014 |
| This study demonistrated that expression of alpha(1)-adrenergic receptors in rat prefrontal cortex and collozation with 5-HT(2A) receptors. | Expression of α(1)-adrenergic receptors in rat prefrontal cortex: cellular co-localization with 5-HT(2A) receptors.
Santana N, Mengod G, Artigas F. | 01/4/2014 |
| Heightened baseline NPY1 receptor and alpha1 adrenergic receptor sympathetic control of blood flow and vascular conductance in prediabetic rats. | Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats.
Novielli NM, Al-Khazraji BK, Medeiros PJ, Goldman D, Jackson DN., Free PMC Article | 04/6/2013 |