| Pendrin abundance, subcellular distribution, and function are unaffected by either alphaENaC gene ablation or by increasing ENaC channel activity. | Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity.
Loffing J, Pech V, Loffing-Cueni D, Abood DC, Kim YH, Chen C, Pham TD, Verlander JW, Wall SM., Free PMC Article | 04/19/2023 |
| Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism. | Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.
Ochiai-Homma F, Kuribayashi-Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, Kawagoe M, Tomomitsu Y, Murakawa M, Asakawa S, Hirohama D, Nagura M, Arai S, Yamazaki O, Tamura Y, Fujigaki Y, Nishikawa T, Shibata S., Free PMC Article | 01/29/2022 |
| These studies implicate the involvement of pendrin-facilitated chloride-bicarbonate exchange in the regulation of airway surface liquid volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases. | Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.
Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS., Free PMC Article | 08/19/2017 |
| these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess. | Iodide excess regulates its own efflux: a possible involvement of pendrin.
Calil-Silveira J, Serrano-Nascimento C, Kopp PA, Nunes MT., Free PMC Article | 08/27/2016 |
| Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. | Pendrin localizes to the adrenal medulla and modulates catecholamine release.
Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, Plotsky PM, Wall SM., Free PMC Article | 12/19/2015 |
| Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats. | Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.
Simão S, Gomes P, Pinho MJ, Soares-da-Silva P. | 08/9/2014 |
| Excessive mucus production, as implicated by significant overexpression of the pendrin coding gene, SLC26A4, was identified as a potential novel mechanism for silica-induced pulmonary toxicity. | Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats.
Sellamuthu R, Umbright C, Roberts JR, Cumpston A, McKinney W, Chen BT, Frazer D, Li S, Kashon M, Joseph P., Free PMC Article | 07/13/2013 |
| These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression. | Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms.
Calil-Silveira J, Serrano-Nascimento C, Nunes MT. | 05/19/2012 |
| Bilateral ureteral obstruction caused a significant reduction in the expression of NHE3, NBC1, NKCC2, NBCn1, and pendrin. | Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney.
Wang G, Li C, Kim SW, Ring T, Wen J, Djurhuus JC, Wang W, Nielsen S, Frøkiaer J. | 01/21/2010 |
| pendrin expression and localisation are regulated by insulin and influenced by a PKC-epsilon-dependent intracellular pathway. | PKC-epsilon-dependent cytosol-to-membrane translocation of pendrin in rat thyroid PC Cl3 cells.
Muscella A, Marsigliante S, Verri T, Urso L, Dimitri C, Bottà G, Paulmichl M, Beck-Peccoz P, Fugazzola L, Storelli C. | 01/21/2010 |
| Pds(pendrin protein) expression is specifically regulated in response to changes in chloride balance in the rat kidney | The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance.
Quentin F, Chambrey R, Trinh-Trang-Tan MM, Fysekidis M, Cambillau M, Paillard M, Aronson PS, Eladari D. | 01/21/2010 |
| its presence in both the apical plasma membrane and the apical intracellular vesicles of type B and non-A-non-B intercalated cells suggests that HCO secretion may be regulated by trafficking between the two membrane compartments | Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney.
Kim YH, Kwon TH, Frische S, Kim J, Tisher CC, Madsen KM, Nielsen S. | 01/21/2010 |
| pendrin and thyroglobulin are downstream targets in vivo of TTF-1, whose action is a prime factor in controlling thyroid differentiation in vivo | Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.
Dentice M, Luongo C, Elefante A, Ambrosio R, Salzano S, Zannini M, Nitsch R, Di Lauro R, Rossi G, Fenzi G, Salvatore D., Free PMC Article | 01/21/2010 |
| Metabolic acidosis and alkalosis with maintained water and sodium intake affected pendrin expression in kidney cortex collecting duct cells; regulation of pendrin expression may be clinically important in the correction of acid-base disturbances | Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading.
Frische S, Kwon TH, Frøkiaer J, Madsen KM, Nielsen S. | 01/21/2010 |
| metabolic acidosis decreases the activity of the apical Cl(-)/HCO(3)(-) exchanger in beta-ICs of the rat CCD by reducing the expression of pendrin. | Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis.
Petrovic S, Wang Z, Ma L, Soleimani M. | 01/21/2010 |
| pendrin expression is regulated in acidotic rats with no changes in aldosterone & no external Cl load.Pendrin reduction may help redirect tubules to Cl excretion & HCO3 reabsorption, leading to increased plasma HCO3 & decreased Cl of respiratory acidosis. | Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule.
de Seigneux S, Malte H, Dimke H, Frøkiaer J, Nielsen S, Frische S. | 01/21/2010 |