| The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure. | The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
Wang Y, Hou X, Wei S, Yan J, Chen Z, Zhang M, Zhang Q, Lu Y, Zhang Q, Zheng T, Jia J, Dong B, Li Y, Zhang Y, Liang J, Li G., Free PMC Article | 03/19/2023 |
| Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons. | Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
Ehses J, Fernández-Moya SM, Schröger L, Kiebler MA., Free PMC Article | 01/1/2022 |
| LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression. | LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Li L, Zheng B, Zhang F, Luo X, Li F, Xu T, Zhao H, Shi G, Guo Y, Shi J, Sun J. | 10/30/2021 |
| Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling | Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R., Free PMC Article | 10/29/2016 |
| After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR | Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
Santhappan R, Crowder AT, Gouty S, Cox BM, Côté TE., Free PMC Article | 01/16/2016 |
| Data suggest that RGS4 proteins play an important pathophysiological role in the development and expression of l-DOPA-induced dyskinesia | RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
Ko WK, Martin-Negrier ML, Bezard E, Crossman AR, Ravenscroft P. | 04/25/2015 |
| partial agonism of the M2 muscarinic receptor is regulated by the RGS4-mediated inhibition of G-protein signalling | RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
Chen IS, Furutani K, Inanobe A, Kurachi Y., Free PMC Article | 02/21/2015 |
| Tra2beta regulates the expression of RGS4 gene and is induced by morphine. | Splicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphine.
Li SJ, Li Y, Cui SC, Qi Y, Zhao JJ, Liu XY, Xu P, Chen XH., Free PMC Article | 01/24/2015 |
| Rgs4 transcript is readily detected but does not respond to hypoxia. Furthermore, this regulation was found to be dependent on transcription, and occurs in a manner consistent with direct HIF transactivation of Rgs4 transcription | Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway.
Olechnowicz SW, Fedele AO, Peet DJ., Free PMC Article | 03/9/2013 |
| data demonstrate that RGS4 in the dorsal striatum attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function | RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling.
Schwendt M, Sigmon SA, McGinty JF., Free PMC Article | 09/29/2012 |
| RGS4 exerted potent inhibitory activities on the signaling of D(2)R/D(3)R. | RGS4 exerts inhibitory activities on the signaling of dopamine D2 receptor and D3 receptor through the N-terminal region.
Min C, Cheong SY, Cheong SJ, Kim M, Cho DI, Kim KM. | 08/25/2012 |
| The functional activity and protein binding partners of a candidate AP-1R sequence were determined for a novel FRA-2-repressed gene, Rgs4. | Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism.
Davies JS, Klein DC, Carter DA., Free PMC Article | 07/16/2011 |
| A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. | A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.
Yang J, Huang J, Chatterjee TK, Twait E, Fisher RA., Free PMC Article | 10/23/2010 |
| RGS4 plays a key role in G protein coupling selectivity and signaling of the mu- and delta-opioid receptors. | Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling.
Leontiadis LJ, Papakonstantinou MP, Georgoussi Z. | 01/21/2010 |
| After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs4, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling. | RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.
Wang X, Adams LD, Pabón LM, Mahoney WM Jr, Beaudry D, Gunaje J, Geary RL, Deblois D, Schwartz SM. | 01/21/2010 |
| Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking. | Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.
Schwendt M, Hearing MC, See RE, McGinty JF. | 01/21/2010 |
| Expression of RGS4 mRNA was not affected by the corticosterone injection, neither in the CA1 area nor in other hippocampal subregions. | Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus.
van Gemert NG, Meijer OC, Morsink MC, Joëls M. | 01/21/2010 |
| study revealed an important coupling of RGS4 to serotonin signaling in cortical neurons and provided a molecular and cellular mechanism underlying the potential involvement of RGS4 in the pathophysiology of schizophrenia. | RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia.
Gu Z, Jiang Q, Yan Z. | 01/21/2010 |
| Amphetamine may disinhibit RGS4-sensitive guanine nucleotide-binding protein alpha-subunit i- and/or q-coupled signaling pathways and favor mechanisms that counterbalance D(1) receptor stimulation. | Acute amphetamine down-regulates RGS4 mRNA and protein expression in rat forebrain: distinct roles of D1 and D2 dopamine receptors.
Schwendt M, Gold SJ, McGinty JF. | 01/21/2010 |
| RGS4 is expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ganglion (DRG) and sciatic nerve transection results in a substantial down regulation of this transcript. | High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
Costigan M, Samad TA, Allchorne A, Lanoue C, Tate S, Woolf CJ. | 01/21/2010 |
| up-regulation of RGS4 expression may contribute to changes in pain signal processing that lead to the development of hyperalgesia, and further affect its modulation by morphine. | Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine.
Garnier M, Zaratin PF, Ficalora G, Valente M, Fontanella L, Rhee MH, Blumer KJ, Scheideler MA. | 01/21/2010 |
| RGS4 was up-regulated only when RGS2 was down-regulated in the striatum after intracerebroventricular injection of forskolin | Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.
Taymans JM, Leysen JE, Langlois X. | 01/21/2010 |
| These observations suggest that RGS4-dependent attenuation of interneuronal autoreceptor signaling is a major factor in the elevation of striatal acetylcholine release in Parkinson disease. | RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion.
Ding J, Guzman JN, Tkatch T, Chen S, Goldberg JA, Ebert PJ, Levitt P, Wilson CJ, Hamm HE, Surmeier DJ. | 01/21/2010 |