| Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic beta-cell apoptosis and dysfunction. | Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction.
Ma L, Zhang C, Wu L, Qin L, Liu T., Free PMC Article | 02/26/2022 |
| C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B. | Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme.
Ghorbani A, Omrani GR, Hadjzadeh MA, Varedi M. | 09/28/2013 |
| PI3K but not Akt is an upstream regulator of the PDE3B pathway of leptin signalling in the rat hypothalamus. | Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus.
Sahu A, Koshinaka K, Sahu M., Free PMC Article | 07/13/2013 |
| Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B. | Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G. | 07/30/2011 |
| PDE3B is activated in response to agents relevant for beta-cell function and activation is linked to increased as well as decreased phosphorylation of the enzyme | Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
Heimann E, Jones HA, Resjö S, Manganiello VC, Stenson L, Degerman E., Free PMC Article | 07/9/2011 |
| PDE3 inhibition reverses leptin-induced stimulation of proopiomelanocortin and neurotensin gene expression; the PDE3B pathway plays an important role in mediating leptin action in the hypothalamus | A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus.
Sahu A., Free PMC Article | 10/23/2010 |
| Increased expression of PDE3B along with decreased cAMP in the exdotoxemic kidneys were associated with reduced renal function, alteration of renal tubular cell morphology, and increased iNOS expression. | The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury.
Choi WI, Kwon KY, Seo JW, Beagle J, Quinn DA, Hales CA., Free PMC Article | 01/21/2010 |
| PDE3B, a key enzyme in insulin signalling, appears to be associated with caveolae in adipocytes and this localization seems to be functionally important. | Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.
Nilsson R, Ahmad F, Swärd K, Andersson U, Weston M, Manganiello V, Degerman E. | 01/21/2010 |
| plays an important role in the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin | Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.
Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS. | 01/21/2010 |
| data suggest that PDE3B, but not PDE4, contributes to the regulation of insulin-induced glucose uptake, GLUT-4 translocation, and lipogenesis presumably by regulation of a cAMP/Epac signalling mechanisms | Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E. | 01/21/2010 |
| insulin and beta-agonists act directly at adipocytes in opposing fashions to regulate production of adiponectin & leptin; PI3K-PDE3B-cAMP pathway mediates effects of insulin to restore beta-agonist/cAMP-suppressed secretion of these adipokines. | Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.
Cong L, Chen K, Li J, Gao P, Li Q, Mi S, Wu X, Zhao AZ., Free PMC Article | 01/21/2010 |
| systemic administration of forskolin increased PDE3A, PDE3B, and PDE4D mRNA levels in aortic VSMC and femoral artery VSMC, 2) local delivery of dbcAMP increased PDE3A, PDE3B, and PDE4D3 protein levels in femoral artery VSMC. | Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo.
Tilley DG, Maurice DH. | 01/21/2010 |