| KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1. | KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1.
Zhang C, Ye W, Zhao M, Long L, Xia D, Fan Z., Free PMC Article | 09/11/2023 |
| The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model. | The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
Li Y, Ma L, Deng Y, Du Z, Guo B, Yue J, Liu X, Zhang Y. | 09/7/2023 |
| the results in this study indicated nerve injury diminishes spinal Hes1-dependent suppression of CDK9-dependent RNAPII phosphorylation on the mGluR5 promoter that possibly enhances mGluR5 transcription/expression for neuropathic pain development. | Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription.
Hsieh MC, Peng HY, Ho YC, Lai CY, Cheng JK, Chen GD, Lin TB., Free PMC Article | 01/25/2020 |
| Penehyclidine hydrochloride alleviates LPS-induced ALI by ameliorating ER stress-mediated apoptosis and promoting Hes1/Notch1 signaling in vivo and in vitro. | Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway.
Weng J, Chen M, Lin Q, Chen J, Wang S, Fang D. | 11/9/2019 |
| MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1 | MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1.
Zhang Y, Peng B, Han Y. | 12/29/2018 |
| This study showed that overexpression of microRNA381 promotes cell proliferation of neurocytes in spinal cord injury via Hes1 expression. | MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury.
Ruan W, Ning G, Feng S, Gao S, Hao Y. | 10/13/2018 |
| Hes1 is upregulated and mediates cardioprotection provided by ischemic postconditioning and suggest that Hes1 is a potential new target for the treatment of ischemic cardiomyopathy. | Hes1 is upregulated by ischemic postconditioning and contributes to cardioprotection.
Zhou XL, Zhao Y, Fang YH, Xu QR, Liu JC. | 10/10/2015 |
| Notch1 signaling appears to interact with TGF-beta/BMP signaling and co-regulates Hes1 expression in activated hepatic stellate cells. | Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling.
Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF., Free PMC Article | 09/26/2015 |
| Hes-1 may play an important role in the pathogenesis of asthma. | [Relationship between Hes-1 and airway inflammation and remodeling in a rat model of asthma].
Qiang BC, Xie L, Liu HM, Fan ZY, Chen LN. | 10/18/2014 |
| The Jagged-2/Notch-1/Hes-1 signaling pathway is involved in intestinal epithelium regeneration early after I/R injury by increasing crypt epithelial cell proliferation. | The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury.
Chen G, Qiu Y, Sun L, Yu M, Wang W, Xiao W, Yang Y, Liu Y, Yang S, Teitelbaum DH, Ma Y, Lu D, Yang H., Free PMC Article | 08/9/2014 |
| results indicate that HES1 acts as a master repressor, the silencing of which is required for proper glucocorticoid signaling. | HES1 is a master regulator of glucocorticoid receptor-dependent gene expression.
Revollo JR, Oakley RH, Lu NZ, Kadmiel M, Gandhavadi M, Cidlowski JA., Free PMC Article | 07/26/2014 |
| The Jagged-1/Notch-1/Hes-1 signaling pathway is involved in intestinal adaptation through increasing crypt epithelial cell proliferation. | The Jagged-1/Notch-1/Hes-1 pathway is involved in intestinal adaptation in a massive small bowel resection rat model.
Chen G, Sun L, Yu M, Meng D, Wang W, Yang Y, Yang H. | 11/30/2013 |
| The rate of mortality, frequency of spontaneous recurrent seizures and incidence of epileptiform waves show a tendency to decrease after treatment with Hes1-bone marrow stromal cell transplantation in epileptic rats. | Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells.
Long Q, Qiu B, Liu W, Fei Z, Feng G, Wang P, Zhong J, Yi X, Liu Y, Zhang Y, Han R. | 04/6/2013 |
| After ischemia and reperfusion, Hes1 intracellular domain level in ischemic striatum in electroacupuncture pretreatment group were increased and reached the peak at 2 h and 24 h. | Electroacupuncture pretreatment induces tolerance against focal cerebral ischemia through activation of canonical Notch pathway.
Zhao Y, Chen X, Ma L, Zuo Z, Zhu Z, Zhu X, Wang Q, He E, Xiong L, Pei J, Xu L, Hou L, Chen S., Free PMC Article | 03/9/2013 |
| The induction of the EL-box-containing promoter by BMAL1/CLOCK or BMAL1/NPAS2 was suppressed by HES1, whereas HES1 does not show any suppressive effect on the E-box element. | Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1.
Ueshima T, Kawamoto T, Honda KK, Noshiro M, Fujimoto K, Nakao S, Ichinose N, Hashimoto S, Gotoh O, Kato Y. | 12/22/2012 |
| Folic acid stimulated the expression of Notch1, Hes1, and Hes5 proteins, and this effect increased with folic acid dose in the rat middle cerebral artery occlusion model of stroke. | Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia.
Zhang X, Huang G, Liu H, Chang H, Wilson JX. | 09/22/2012 |
| JNK1 phosphorylation of Hes-1 stabilizes the Hes-1 protein and enhances the suppressing effect of Hes-1 on GluR1 expression. | JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1.
Lin CH, Lee EH., Free PMC Article | 03/24/2012 |
| Renal ischemia/reperfusion injury activates Notch2/Hes-1 signaling. | Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the γ-secretase inhibitor DAPT has a nephroprotective effect.
Huang R, Zhou Q, Veeraragoo P, Yu H, Xiao Z. | 06/18/2011 |
| Hes1 was expressed on postnatal days 0 - 3 in rat greater epithelial ridge cells. | [Expression of three kinds of transcription factors in greater epithelial ridge cells of rat cochlear].
Zhang Y, Hu YY, Song W, Guo WW, Zhai SQ. | 03/12/2011 |
| Data indicate that exposure of hippocampal neural precursor cells to TNFalpha during differentiation but not proliferation has a detrimental effect on their neuronal lineage fate, which may be mediated through increased expression of Hes1. | Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1.
Keohane A, Ryan S, Maloney E, Sullivan AM, Nolan YM. | 05/3/2010 |
| The ability of truncated versions of Hes1 to bind Ptf1-p48 correlates with their ability to down-regulate the activity of the PTF1 transcriptional complex. | Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.
Ghosh B, Leach SD., Free PMC Article | 01/21/2010 |
| Regulated lipocalin-type prostaglandin D synthase gene expression through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells. | Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells.
Fujimori K, Fujitani Y, Kadoyama K, Kumanogoh H, Ishikawa K, Urade Y. | 01/21/2010 |
| HES-1 is a regulator of intracellular signal transduction stimulated by cell adhesion molecules involved in neurite outgrowth. | Neural cell adhesion molecule-mediated neurite outgrowth is repressed by overexpression of HES-1.
Jessen U, Novitskaya V, Walmod PS, Berezin V, Bock E. | 01/21/2010 |
| Hes1 can drive GRPs to an astrocyte cell fate at the expense of oligodendrocyte differentiation. | Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.
Wu Y, Liu Y, Levine EM, Rao MS. | 01/21/2010 |