| Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury. | Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury.
Chen L, Fang H, Li X, Yu P, Guan Y, Xiao C, Deng Z, Hei Z, Chen C, Luo C., Free PMC Article | 02/20/2024 |
| GJB1 mutations c.212T>G and c.311A>C induce apoptosis and inwardly rectifying potassium current changes in X-linked Charcot-Marie-Tooth type 1. | GJB1 mutations c.212T>G and c.311A>C induce apoptosis and inwardly rectifying potassium current changes in X-linked Charcot-Marie-Tooth type 1.
Guo H, Liu Y, Gu J, Luo J, Ma Y, Xiao F. | 01/1/2022 |
| Heart and liver connexin expression related to the first stage of aging: A study on naturally aged animals. | Heart and liver connexin expression related to the first stage of aging: A study on naturally aged animals.
Moscato S, Cabiati M, Bianchi F, Panetta D, Burchielli S, Massimetti G, Del Ry S, Mattii L. | 09/4/2021 |
| Crosstalk Between Connexin32 and Mitochondrial Apoptotic Signaling Pathway Plays a Pivotal Role in Renal Ischemia Reperfusion-Induced Acute Kidney Injury. | Crosstalk Between Connexin32 and Mitochondrial Apoptotic Signaling Pathway Plays a Pivotal Role in Renal Ischemia Reperfusion-Induced Acute Kidney Injury.
Chen C, Yao W, Wu S, Zhou S, Ge M, Gu Y, Li X, Chen G, Bellanti JA, Zheng SG, Yuan D, Hei Z., Free PMC Article | 08/22/2020 |
| these results highlight the role of post translational modifications and lysines in the C-terminal tail of Cx32 in the fine-tuning of Cx32 protein stability and channel-independent functions. | Acetylation of C-terminal lysines modulates protein turnover and stability of Connexin-32.
Alaei SR, Abrams CK, Bulinski JC, Hertzberg EL, Freidin MM., Free PMC Article | 12/22/2018 |
| In vitro gain and loss of function analyses showed overexpression of Connexin 32 and knockdown of Connexin 43 promoted hepatocytes differentiation from hepatic progenitor cells. | Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes.
Pei H, Zhai C, Li H, Yan F, Qin J, Yuan H, Zhang R, Wang S, Zhang W, Chang M, Wang Y, Pei X., Free PMC Article | 07/14/2018 |
| retrograde influences originating from the peripheral injury site elicit dramatic changes in the central nervous system expression of Connexin 32, which in turn may mediate the plasticity of oligodendrocyte lineage cells observed in the spinal cord following peripheral axon injury. | Increased Cx32 expression in spinal cord TrkB oligodendrocytes following peripheral axon injury.
Coulibaly AP, Isaacson LG., Free PMC Article | 06/24/2017 |
| Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. | Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis.
Kato H, Naiki-Ito A, Naiki T, Suzuki S, Yamashita Y, Sato S, Sagawa H, Kato A, Kuno T, Takahashi S., Free PMC Article | 12/17/2016 |
| Cx 32 and Cx 43 associated with oligodendrocytes and astrocytes had an important role in the first stages of seizures induced by 4-AP, whereas Cx36 localized to neurons could be associated with later stages. | Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus.
Laura MC, Xóchitl FP, Anne S, Alberto MV., Free PMC Article | 04/23/2016 |
| Cx32 and luteolin have suppressive roles in inflammation, fibrosis and hepatocarcinogenesis during non-alcoholic steatohepatitis progression. | Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats.
Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S. | 03/26/2016 |
| Modulating gap junction by Cx32 gene silencing protected BRL-3A liver cells from hypoxia/reoxygenation injury. | Downregulation of connexin 32 attenuates hypoxia/reoxygenation injury in liver cells.
Wang R, Huang F, Chen Z, Li S. | 01/30/2016 |
| Tryptophan was substituted for residues in all four transmembrane domains of connexin32. Tryptophan substitution was poorly tolerated in all domains, with the greatest impact in TM1 and TM4. | Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32.
Brennan MJ, Karcz J, Vaughn NR, Woolwine-Cunningham Y, DePriest AD, Escalona Y, Perez-Acle T, Skerrett IM., Free PMC Article | 10/3/2015 |
| Studies have shown connexin32 expression increases when liver or brain damage becomes more serious and these damages can be blocked by Cx32 inhibitors through decreasing oxidative stress and cell apoptosis. | Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexin 32.
Luo C, Yuan D, Li X, Yao W, Luo G, Chi X, Li H, Irwin MG, Xia Z, Hei Z. | 03/28/2015 |
| Low extracellular pH can regulate pancreatic acinar cell gap junctional intercellular communication by enhancing connexin32 degradation. | Low pH enhances connexin32 degradation in the pancreatic acinar cell.
Reed AM, Kolodecik T, Husain SZ, Gorelick FS., Free PMC Article | 08/30/2014 |
| Cx32 gap junction communication in the hippocampus does not contribute to kindling epileptogenesis | Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy.
Akbarpour B, Sayyah M, Babapour V, Mahdian R, Beheshti S, Kamyab AR., Free PMC Article | 07/26/2014 |
| Transcriptional overexpression of hippocampal Cx30 and Cx32 could be an adaptive response to production of intracellular toxic molecules but it is not accompanied with post- transcriptional overexpression and might have no functional impact. | Upregulation of connexins 30 and 32 gap junctions in rat hippocampus at transcription level by chronic central injection of lipopolysaccharide.
Abbasian M, Sayyah M, Babapour V, Mahdian R, Choopani S, Kaviani B., Free PMC Article | 06/29/2013 |
| Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM. | Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
Stauch K, Kieken F, Sorgen P., Free PMC Article | 11/17/2012 |
| connexin32 hemichannels facilitate the apoptotic-to-necrotic transition, which typically occurs in the final stage of hepatocellular apoptosis | Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death.
Vinken M, Decrock E, De Vuyst E, De Bock M, Vandenbroucke RE, De Geest BG, Demeester J, Sanders NN, Vanhaecke T, Leybaert L, Rogiers V., Free PMC Article | 03/22/2010 |
| Cx43 and Cx32 undergo a multistep conformational maturation process in which folding of connexin monomers within the endoplasmic reticulum is a prerequisite for multisubunit assembly in the trans-Golgi network. | Conformational maturation and post-ER multisubunit assembly of gap junction proteins.
Vanslyke JK, Naus CC, Musil LS., Free PMC Article | 01/21/2010 |
| magnitude of cell proliferation was inversely proportional to level of cx32 expression in a hepatoma cell line; inverse relationship between Cx32 expression & proliferation was continuous | A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line.
Edwards GO, Jondhale S, Chen T, Chipman JK. | 01/21/2010 |
| a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction. | Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.
Kotsias BA, Salim M, Peracchia LL, Peracchia C. | 01/21/2010 |
| Cx32 is downregulated by the ILK pathway activation in rat hepatocytes and this is mediated via the activation and nuclear translocation of Akt | Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt.
Plante I, Charbonneau M, Cyr DG. | 01/21/2010 |
| In the current experiments, immunoblot and immunohistochemical protocols were used to investigate the regional distribution and cellular localization of Cx36 in putative CO2-chemosensitive brainstem regions in both neonatal and adult rats. | Connexin36 distribution in putative CO2-chemosensitive brainstem regions in rat.
Solomon IC. | 01/21/2010 |
| analysis of functional regulatory regions of the connexin32 gene promoter | Identification of functional regulatory regions of the connexin32 gene promoter.
Field JM, Tate LA, Chipman JK, Minchin SD. | 01/21/2010 |
| role of Cx32 in forming channels permeable to adenosine, AMP, ADP, ATP | Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP.
Goldberg GS, Moreno AP, Lampe PD. | 01/21/2010 |