| Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling. | Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
Thonda S, Puttapaka SN, Kona SV, Kalivendi SV. | 12/4/2021 |
| Abeta1-42 oligomers trigger an aberrant plasticity mechanism according to which Abeta1-42 oligomers can downregulate Abeta generation through the modulation of ADAM10 synaptic availability. | Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena.
Marcello E, Musardo S, Vandermeulen L, Pelucchi S, Gardoni F, Santo N, Antonucci F, Di Luca M., Free PMC Article | 02/1/2020 |
| This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation. | Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
Boccalini G, Sassoli C, Bani D, Nistri S. | 04/27/2019 |
| our results indicate a positive role of PLD1 in synaptogenesis by inhibiting the ADAM10 mediated N-cadherin cleavage and provide new therapeutic clues for some neurological diseases. | PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.
Luo LD, Li G, Wang Y., Free PMC Article | 02/2/2019 |
| In this study, we demonstrated that ADAM10 plays an important role in PAX2-induced EMT in the renal tubular epithelia | PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Hou L, Du Y, Zhao C, Wu Y., Free PMC Article | 12/22/2018 |
| Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells. | Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
Li J, Ouyang Q, Chen CW, Chen QB, Li XN, Xiang ZH, Yuan HB. | 06/2/2018 |
| These results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1. | Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin.
Dursun E, Gezen-Ak D., Free PMC Article | 12/23/2017 |
| TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19 | Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Ramdas V, McBride M, Denby L, Baker AH., Free PMC Article | 07/5/2014 |
| Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis. | MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury.
Warren KM, Reeves TM, Phillips LL., Free PMC Article | 05/25/2013 |
| PACAP38 is involved in the modulation of dendritic spine morphology in hippocampal neurons; the ADAM10-N-cadherin signaling pathway plays a crucial role in this modification of the excitatory glutamatergic synapse. | The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway.
Gardoni F, Saraceno C, Malinverno M, Marcello E, Verpelli C, Sala C, Di Luca M. | 02/16/2013 |
| These results strongly suggest that TACE/ADAM17 participates in in vivo apoptosis of male germ cells induced by DNA damage. | Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis.
Lizama C, Rojas-Benitez D, Antonelli M, Ludwig A, Moreno RD. | 02/4/2012 |
| alpha- and gamma-secretase processing of nectin-1 is a Ca(2+)/calmodulin-regulated event that occurs under conditions of activity-dependent synaptic plasticity and ADAM10 and gamma-secretase are responsible for these cleavage events. | Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).
Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST., Free PMC Article | 08/23/2010 |
| Elevation of ADAM10 is associated with thoracic aortic aneurysm. | Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.
Geng L, Wang W, Chen Y, Cao J, Lu L, Chen Q, He R, Shen W. | 08/9/2010 |
| during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve. | Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve.
Jangouk P, Dehmel T, Meyer Zu Hörste G, Ludwig A, Lehmann HC, Kieseier BC. | 01/21/2010 |
| ADAM10 expression was induced in dentate gyrus of hippocampus. The spatiotemporal expression of ADAM10 suggests that its regulation after the KA-induced status epilepticus could be related to neuroprotection. | ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
Ortiz RM, Kärkkäinen I, Huovila AP, Honkaniemi J. | 01/21/2010 |
| experiments establish amyloid precursor protein, nicastrin, and presenilin-1 as resident lysosomal membrane proteins and indicate that gamma-secretase is a lysosomal protease | Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ. | 01/21/2010 |
| gamma-secretase activation and ErbB4 intracellular domain nuclear translocation are required for oligodendrocyte maturation induced by neuregulin | Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes.
Lai C, Feng L. | 01/21/2010 |