| P2X7 receptors exhibit at least three modes of allosteric antagonism. | P2X(7) receptors exhibit at least three modes of allosteric antagonism.
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE., Free PMC Article | 10/10/2024 |
| Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors. | Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors.
De Salis SKF, Chen JZ, Skarratt KK, Fuller SJ, Balle T. | 09/13/2024 |
| LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury. | LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury.
Wang Y, Chen Z, Liu Q, Lv Y. | 07/15/2024 |
| Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function. | Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function.
Rupert M, Bhattacharya A, Sivcev S, Knezu M, Cimicka J, Zemkova H. | 08/24/2023 |
| Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7. | Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7.
Hu QQ, He XF, Ma YQ, Ma LQ, Qu SY, Wang HZ, Kang YR, Chen LH, Li X, Liu BY, Shao XM, Fang JF, Liang Y, Fang JQ, Jiang YL., Free PMC Article | 08/7/2023 |
| Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis. | Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis.
Xiao J, Li Y, Zhang J, Xu G, Zhang J. | 06/19/2023 |
| Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways. | Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Liu C, Tian Q, Wang J, He P, Han S, Guo Y, Yang C, Wang G, Wei H, Li M. | 01/28/2023 |
| Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn. | Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn.
Sun S, Jiang W, Yan X, Zhang J, Gao L, Wu C, Zhu B, Wu L. | 01/11/2023 |
| Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCepsilon/P38MAPK/NF-kappaB Signaling Pathway in Rats. | Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats.
Chen L, Wang H, Xing J, Shi X, Huang H, Huang J, Xu C., Free PMC Article | 12/10/2022 |
| P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling. | P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling.
Wu P, Wu X, Zhou G, Wang Y, Liu X, Lv R, Liu Y, Wen Q. | 11/19/2022 |
| New insights into P2X7 receptor regulation: Ca(2+)-calmodulin and GDP bind to the soluble P2X7 ballast domain. | New insights into P2X7 receptor regulation: Ca(2+)-calmodulin and GDP bind to the soluble P2X7 ballast domain.
Sander S, Müller I, Garcia-Alai MM, Nicke A, Tidow H., Free PMC Article | 11/5/2022 |
| HMGB1-NLRP3-P2X7R pathway participates in PM2.5-induced hippocampal neuron impairment by regulating microglia activation. | HMGB1-NLRP3-P2X7R pathway participates in PM(2.5)-induced hippocampal neuron impairment by regulating microglia activation.
Liu C, She Y, Huang J, Liu Y, Li W, Zhang C, Zhang T, Yu L. | 08/13/2022 |
| Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes. | Aβ(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Dias L, Madeira D, Dias R, Tomé ÂR, Cunha RA, Agostinho P., Free PMC Article | 08/6/2022 |
| P2X7 receptor-mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats. | P2X7 receptor-mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats.
Staal R, Khayrullina T, Christensen R, Hestehave S, Zhou H, Cajina M, Nattini ME, Gandhi A, Fallon SM, Schmidt M, Zorn SH, Brodbeck RM, Chandrasena G, Segerdahl M, Breysse N, Hopper AT, Möller T, Munro G. | 06/18/2022 |
| Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways. | Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.
Prendecki M, McAdoo SP, Turner-Stokes T, Garcia-Diaz A, Orriss I, Woollard KJ, Behmoaras J, Cook HT, Unwin R, Pusey CD, Aitman TJ, Tam FW., Free PMC Article | 06/11/2022 |
| Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation. | Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation.
Wu YY, Zhang HL, Lu X, Du H, Li YC, Zhang PA, Xu GY., Free PMC Article | 05/14/2022 |
| P2X7 receptor: the regulator of glioma tumor development and survival. | P2X7 receptor: the regulator of glioma tumor development and survival.
Matyśniak D, Chumak V, Nowak N, Kukla A, Lehka L, Oslislok M, Pomorski P., Free PMC Article | 04/23/2022 |
| P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models. | P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models.
Wu P, Zhou G, Wu X, Lv R, Yao J, Wen Q., Free PMC Article | 04/2/2022 |
| Astragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis. | Astragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis.
Jia X, Xie L, Liu Y, Liu T, Yang P, Hu J, Peng Z, Luo K, Du M, Chen C., Free PMC Article | 03/26/2022 |
| High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus. | High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus.
Zhao YF, Ren WJ, Zhang Y, He JR, Yin HY, Liao Y, Rubini P, Deussing JM, Verkhratsky A, Yuan ZQ, Illes P, Tang Y., Free PMC Article | 03/12/2022 |
| Dissecting activation steps in P2X7 receptors. | Dissecting activation steps in P2X7 receptors.
Gusic M, Benndorf K, Sattler C. | 11/27/2021 |
| P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors. | P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
Tan SL, Barri M, Atakpa-Adaji P, Taylor CW, St John Smith E, Murrell-Lagnado RD., Free PMC Article | 10/30/2021 |
| Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus. | Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus.
Lee DS, Kim JE., Free PMC Article | 10/9/2021 |
| P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells. | P2Y(13) and P2X(7) receptors modulate mechanically induced adenosine triphosphate release from mast cells.
Shen D, Shen X, Schwarz W, Grygorczyk R, Wang L. | 10/2/2021 |
| P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-kappaB/NLRP3 Crosstalk. | P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L., Free PMC Article | 09/4/2021 |