| Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS). | LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
Shao Z, Lee X, Huang G, Sheng G, Henderson CE, Louvard D, Sohn J, Pepinsky B, Mi S., Free PMC Article | 08/19/2017 |
| hypoxia or GSN overexpression induces HIF-1alpha expression and reduces the expression of survival markers p-Akt and Bcl-2 in H9c2 cardiomyoblast cells | Hypoxia Augments Increased HIF-1α and Reduced Survival Protein p-Akt in Gelsolin (GSN)-Dependent Cardiomyoblast Cell Apoptosis.
Yeh YL, Hu WS, Ting WJ, Shen CY, Hsu HH, Chung LC, Tu CC, Chang SH, Day CH, Tsai Y, Huang CY. | 01/28/2017 |
| These findings suggested a potential role of GSN in the pathophysiology of the brain at the early stage of subarachnoid hemorrhage. | Expression of Cytoplasmic Gelsolin in Rat Brain After Experimental Subarachnoid Hemorrhage.
Xie GB, Wang CX, Zhou CH, Li H, Zhang XS, Zhou XM, Zhang L, Hang CH, Zhou ML, Shi JX. | 04/2/2016 |
| our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex | The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M., Free PMC Article | 10/17/2015 |
| It was concluded that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-IIdelta, binding of CaMK-IIdelta and gelsolin to actin filaments, and cleavage of gelsolin. | Involvement of CaMK-IIδ and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells.
Liu Y, Templeton DM. | 01/5/2013 |
| We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease | Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Wen JJ, Garg NJ., Free PMC Article | 08/11/2012 |
| This report indicates that structural differences between plasma and cytoplasmic gelsolin do not play a key role in their complex formation with Abeta. | Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein.
Ji L, Chauhan A, Chauhan V. | 01/21/2010 |
| Gelsolin is found at high levels (comparable to plasma) in mesenteric lymph. Following hemorrhagic shock, gelsolin levels decrease significantly, possibly due to consumption by the actin scavenging system. | Gelsolin is depleted in post-shock mesenteric lymph.
Jordan JR, Moore EE, Damle SS, Eckels P, Johnson JL, Roach JP, Redzic JS, Hansen KC, Banerjee A., Free PMC Article | 01/21/2010 |
| Results suggest that the spatiotemporal upregulation of gelsolin in the hippocampus is induced by entorhinal deafferentation. | Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation.
Dong JH, Ying GX, Liu X, Wang WY, Wang Y, Ni ZM, Zhou CF. | 01/21/2010 |
| gelsolin modulates the actin cytoskeleton and regulates vacuolar H+-ATPase recycling | Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.
Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. | 01/21/2010 |
| Gelsolin is a component of Sertoli cell intercellular adhesion complexes, and plays a role in the disassembly of actin filaments and in the resulting release of sperm. | Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells.
Guttman JA, Janmey P, Vogl AW. | 01/21/2010 |
| observed ubiquitous increase of gelsolin in senescent states of cells and tissues, and increased sensitivity to apoptosis-induction by gelsolin down-regulation, suggests that it would be partly responsible for age-related apoptosis resistance. | Aging-associated increase of gelsolin for apoptosis resistance.
Ahn JS, Jang IS, Kim DI, Cho KA, Park YH, Kim K, Kwak CS, Chul Park S. | 01/21/2010 |