| CaMK4 is a downstream effector of the alpha1G T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells. | CaMK4 is a downstream effector of the α(1G) T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells.
Zheng Z, Wang X, Wang Y, King JAC, Xie P, Wu S. | 12/11/2021 |
| Recombinant adenovirus encoding enhanced green fluorescent protein-CaV3.1 subunit (Ad-EGFP-CaV3.1) efficiently transduced rat and human islets as well as dispersed islet cells. Ad-EGFP-CaV3.1 transduction reduced phosphorylated FoxO1 in the cytoplasm of rat INS-1E cells, elevated FoxO1 nuclear retention, and decreased syntaxin 1A, SNAP-25, and synaptotagmin III. | Enhanced expression of β cell Ca(V)3.1 channels impairs insulin release and glucose homeostasis.
Yu J, Shi Y, Zhao K, Yang G, Yu L, Li Y, Andersson EM, Ämmälä C, Yang SN, Berggren PO., Free PMC Article | 05/16/2020 |
| The present work demonstrated that miR-137 and its target T-type CaV 3.1 channel modulate the dedifferentiation and proliferation of rat cerebrovascular smooth muscle cells under simulated microgravity by regulating calcineurin/NFATc3 pathway. | miR-137 and its target T-type Ca(V) 3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway.
Zhang B, Chen L, Bai YG, Song JB, Cheng JH, Ma HZ, Ma J, Xie MJ., Free PMC Article | 04/18/2020 |
| Results confirm the idea that T-channels critically support rebound burst firing following periods of membrane hyperpolarization, similar to those that occur during inhibitory synaptic potentials in the ventral tegmental area. Behavioral results indicate that deletion of CaV3.1 channels disrupts the hyperlocomotion. | Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.
Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM., Free PMC Article | 02/23/2019 |
| Results show that the decrease in Cav3.1 channel expression and Ca2+ current component that they carry in thalamocortical relay neurons serves as a protective measure against early onset of spike-wave discharges and absence seizures | Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy.
Sharop BR, Boldyriev OI, Batiuk MY, Shtefan NL, Shuba YM. | 10/1/2016 |
| Results suggest that T-type Ca channels Cav3.1, Cav3.2 and Cav3.3 are potential therapeutic targets for the treatment of spinal nerve ligation-induced neuropathic pain. | Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
Yue J, Liu L, Liu Z, Shu B, Zhang Y. | 09/7/2013 |
| Inhibition of Cav3.1 wild type by Ni(2+) conformed to two sites binding. | Complex modulation of Ca(v)3.1 T-type calcium channel by nickel.
Nosal OV, Lyubanova OP, Naidenov VG, Shuba YM., Free PMC Article | 06/15/2013 |
| L- and T-type Ca(2+) channels are expressed in cerebral arterial smooth muscle and both conductances contribute to myogenic tone. | Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development.
Abd El-Rahman RR, Harraz OF, Brett SE, Anfinogenova Y, Mufti RE, Goldman D, Welsh DG., Free PMC Article | 02/23/2013 |
| T-type Ca(2)+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes. | T-type Ca²+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes.
Ferron L, Ruchon Y, Renaud JF, Capuano V., Free PMC Article | 07/16/2011 |
| Cav3.1 T-type channels interact with divalent calcium ion-dependent steps of the mitogenic signaling cascade as a central component of vascular remodeling in disease. | Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells.
Pluteanu F, Cribbs LL., Free PMC Article | 04/23/2011 |
| Downregulation of CaV3.1 T-type calcium channel attenuates energy deficiency-mediated calcium accumulation and cell death. | Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca2+ channel.
Pastukh V, Chen H, Wu S, Jong CJ, Alexeyev M, Schaffer SW., Free PMC Article | 08/23/2010 |
| These results indicate that both glucocorticoid receptor and NFkappaB are necessary, but not sufficient, to trigger an increase in Ca(v)3.1 mRNA amount. | Regulation of T-type Cav3.1 channels expression by synthetic glucocorticoid dexamethasone in neonatal cardiac myocytes.
BenMohamed F, Ferron L, Ruchon Y, Gouadon E, Renaud JF, Capuano V. | 01/21/2010 |
| Ca(v)3.1 and Ca(v)3.2 T-type calcium channels are differentially regulated by hypoxia/reoxygenation injury, and, therefore, they may serve different functions in the myocyte in response to hypoxic injury. | T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes.
Pluteanu F, Cribbs LL., Free PMC Article | 01/21/2010 |
| CaV3.1 structural analysis and comparison to CaV1.2 channel | Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture.
Walsh CP, Davies A, Butcher AJ, Dolphin AC, Kitmitto A., Free PMC Article | 01/21/2010 |
| Our data identify a new fast calcium signaling pathway in Purkinje cell dendritic spines triggered by short burst of parallel fiber inputs and mediated by Ca(v)3.1 T-type calcium channels and mGluR1s. | Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
Hildebrand ME, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, Schneider T, Hescheler J, Kano M, Sakimura K, Watanabe M, Dieudonné S, Snutch TP., Free PMC Article | 01/21/2010 |
| Both L- and T-type channels mediate Ca(2+) entry during conducted vasoconstriction to local KCl in mesenteric arterioles. | The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles.
Braunstein TH, Inoue R, Cribbs L, Oike M, Ito Y, Holstein-Rathlou NH, Jensen LJ. | 01/21/2010 |
| Alternative splicing of Ca(v)3 channels regulates surface expression and may underlie disease states in which T-channel current density is increased | Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.
Shcheglovitov A, Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E., Free PMC Article | 01/21/2010 |
| Our data suggest an involvement of CaV3.1 in intracellular Ca2+regulation in mature OHCs | The CaV3.1 T-type Ca2+channel contributes to voltage-dependent calcium currents in rat outer hair cells.
Inagaki A, Ugawa S, Yamamura H, Murakami S, Shimada S. | 01/21/2010 |
| Ca(V)3.1 channels were not found in sperm. | Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice.
Escoffier J, Boisseau S, Serres C, Chen CC, Kim D, Stamboulian S, Shin HS, Campbell KP, De Waard M, Arnoult C. | 01/21/2010 |
| mRNA transcripts for the voltage-gated Ca2+ channel alpha 1G subunit have been detected in rat astrocytes. | Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes.
Latour I, Hamid J, Beedle AM, Zamponi GW, Macvicar BA. | 01/21/2010 |
| T-type calcium channels may play role in expression of neuropathic state. Selective T-type calcium channel blockers may have significant potential in treatment of neuropathic pain. | Reversal of experimental neuropathic pain by T-type calcium channel blockers.
Dogrul A, Gardell LR, Ossipov MH, Tulunay FC, Lai J, Porreca F. | 01/21/2010 |
| activation of Cav3.1 T-type Ca2+ channels in PMVECs provides a unique cytosolic Ca2+ source important for Gq-linked agonist-induced von Willebrand factor release | Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells.
Zhou C, Chen H, Lu F, Sellak H, Daigle JA, Alexeyev MF, Xi Y, Ju J, van Mourik JA, Wu S., Free PMC Article | 01/21/2010 |