| Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1. | Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1.
Zhang SS, Wu YJ, Pan S, Wang QH, Chen WG, Wang ZF, Xu JY, Zuo J, Yin Q. | 01/28/2023 |
| Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation. | Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation.
Radziejewska A, Suliburska J, Kołodziejski P, Chmurzynska A. | 08/21/2021 |
| Folate deficiency alters the expression of folate transporters RFC and folate exporter ABCG2 in the adult group differently than weanling group and young group both at the transcriptional and translational level, which in turn was found to be epigenetically regulated by promoter methylation of the RFC and ABCG2 genes. | Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation.
Ahmad Najar R, Rahat B, Hussain A, Thakur S, Kaur J, Kaur J, Hamid A. | 12/9/2017 |
| decreased levels of PCFT and RFC expression in rat PPM are due to decreased association of these proteins with lipid rafts (LR) at the PPM | Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion.
Wani NA, Nada R, Kaur J., Free PMC Article | 07/21/2012 |
| Data suggest that malabsorption of folate in colon associated with alcoholism is due, in part, to down-regulation of folate transporter expression and association with lipid rafts (for both RFC/Slc19a1 and proton-coupled folate transporter/Slc46a1). | Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats.
Wani NA, Hamid A, Khanduja KL, Kaur J. | 04/21/2012 |
| Downregulation in the expression of the PCFT and the RFC in colon results in reduced levels of these transporters in colon apical membrane lipid rafts as a mechanism of folate malabsorption during chronic alcoholism. | Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism.
Wani NA, Kaur J. | 01/29/2011 |
| Fusions of GFP with the shorter ORFs of all alternative slc19a1 transcripts containing 6-7 predicted TMD were expressed less efficiently and not sorted to the plasma membrane | Alternative transcripts of rat slc19a1: defective sorting and inefficient expression of alternative splicing products--an addendum.
Schrader S, Kneuer C, Said HM, Honscha W. | 01/21/2010 |
| in IEC-6 cells, folate transport at neutral pH is mediated predominantly by RFC; however, the folate transport activity at pH 5.5 is RFC independent. | Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function.
Wang Y, Rajgopal A, Goldman ID, Zhao R. | 01/21/2010 |
| Three minor mRNA forms resulted from absent splicing of intron III, a shortened exon III, and a shortened exon IV. The minor transcripts were predicted to result in translation products with 7 or 6 instead of 12 transmembrane domains. | Alternative transcripts of rat slc19a1: cloning, genomic organisation, tissue specific promoters and alternative splicing.
Kneuer C, Schrader S, Honscha W. | 01/21/2010 |
| cloned and sequenced the renal sodium-dependent methotrexate carrier-1 and characterized its substrate spectrum | Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization.
Kneuer C, Honscha KU, Honscha W. | 01/21/2010 |
| Reduced folate carrier/Slc19a1 is the major (if not the only) folate uptake system that is functional in intestinal epithelial cells. | Role of reduced folate carrier in intestinal folate uptake.
Balamurugan K, Said HM. | 01/21/2010 |