| Sema3A ameliorates the pathological progression of osteoarthritis by modulating mitochondrial damage in chondrocytes. | Sema3A ameliorates the pathological progression of osteoarthritis by modulating mitochondrial damage in chondrocytes.
Guo Z, Qin Y, Li Y, Tang P. | 03/14/2024 |
| Pure platelet-rich plasma promotes semaphorin-3A expression: a novel insight to ameliorate intervertebral disk degeneration in vitro. | Pure platelet-rich plasma promotes semaphorin-3A expression: a novel insight to ameliorate intervertebral disk degeneration in vitro.
Huang J, Lian SL, Han JH, Lu ZC, Ding Y., Free PMC Article | 11/3/2023 |
| Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues. | Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues.
Qiu Q, Yu X, Chen Q, He X. | 05/4/2023 |
| Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/beta-catenin signaling pathway. | Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/β-catenin signaling pathway.
Sun Z, Yan K, Liu S, Yu X, Xu J, Liu J, Li S. | 03/12/2022 |
| Neuropilin-1 receptor in the rapid and selective estrogen-induced neurovascular remodeling of rat uterus. | Neuropilin-1 receptor in the rapid and selective estrogen-induced neurovascular remodeling of rat uterus.
Richeri A, Vierci G, Martínez GF, Latorre MP, Chalar C, Brauer MM. | 06/19/2021 |
| miR-30b overexpression and Sema3A siRNA could statistically significantly promote the growth of axons while inhibiting the growth of dendrites from retinal ganglion cells. | MicroRNA-30b regulates the polarity of retinal ganglion cells by inhibiting semaphorin-3A.
Chan-Juan H, Sen L, Li-Qianyu A, Jian Y, Rong-Di Y., Free PMC Article | 06/20/2020 |
| Study found that agonist activity directed at the alpha2 but not the alpha1 subunit of the GABAA receptor is required to inhibit the collapse response to Sema3A in dissociated cortical neurons. | Anesthetics disrupt growth cone guidance cue sensing through actions on the GABA(A) α2 receptor mediated by the immature chloride gradient.
Xu J, Xu M, Wang Y, Mathena RP, Wen J, Zhang P, Furmanski O, Mintz CD., Free PMC Article | 05/16/2020 |
| markedly suppressed in annulus fibrosis tissues of an intervertebral disc degeneration model | Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis.
Mima Y, Suzuki S, Fujii T, Morikawa T, Tamaki S, Takubo K, Shimoda M, Miyamoto T, Watanabe K, Matsumoto M, Nakamura M, Fujita N. | 12/21/2019 |
| Stimulation with oxygen glucose deprivation induces neuronal expression of VEGF165 and regulates the migration of vascular endothelial cells, thereby enhancing their participation in angiogenesis, which may involve Sema3A. | Roles of Sema3A and VEGF165 in cortical neurons and vascular endothelial cells during oxygen glucose deprivation stimulation.
Yang Y, Li C, Wang R, Wang H, Ma Q, He Y, Zhang P. | 08/31/2019 |
| Sema3A is a target of miR-145-5p in the adipose-derived stem cells.Sema3a role in the osteogenesis and adipogenesis. | miR-145-5p suppresses osteogenic differentiation of adipose-derived stem cells by targeting semaphorin 3A.
Liu X, Zhu W, Wang L, Wu J, Ding F, Song Y. | 06/15/2019 |
| High glucose up-regulates Sema3A expression by activating mTOR signaling in diabetic keratinocytes. | High glucose up-regulates Semaphorin 3A expression via the mTOR signaling pathway in keratinocytes: A potential mechanism and therapeutic target for diabetic small fiber neuropathy.
Wu LY, Li M, Qu ML, Li X, Pi LH, Chen Z, Zhou SL, Yi XQ, Shi XJ, Wu J, Wang S. | 04/27/2019 |
| Sema3A controls olfactory ensheathing cell migration through cofilin activation during olfactory nerve layer formation. | Semaphorin 3A as an inhibitive factor for migration of olfactory ensheathing cells through cofilin activation is involved in formation of olfactory nerve layer.
Wang Y, Bao X, Wu S, Shen X, Zhang F, Lv Z, Wu Q, Xie C, Liu H, Lin J, Teng H, Huang Z. | 03/9/2019 |
| decreased expression of Sema3A in bone mesenchymal stem cells from type 2 diabetes mellitus rats compared with bone mesenchymal stem cells from normal rats. | Semaphorin 3A promotes osteogenic differentiation of BMSC from type 2 diabetes mellitus rats.
Qiao Q, Xu X, Song Y, Song S, Zhu W, Li F. | 10/27/2018 |
| decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis | Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis.
Lin Y, Xing Q, Qin W, de Melo MAS, Zou R, Xu M, Zhang X, Xu HHK, Lin Z., Free PMC Article | 08/18/2018 |
| describe microfabrication and substrate stripe micropatterning of Sema3A | Photolithography-Based Substrate Microfabrication for Patterning Semaphorin 3A to Study Neuronal Development.
Shelly M, Lee SI, Suarato G, Meng Y, Pautot S., Free PMC Article | 02/17/2018 |
| describe methods to visualize endocytosed Semaphorin3A (Sema3A) molecules and to characterize the rate and pathway of internalization in primary rat neuronal cultures using semiconductor quantum dot nanoparticles | Visualizing and Characterizing Semaphorin Endocytic Events Using Quantum Dot-Conjugated Proteins.
Carcea I, Benson DL. | 02/17/2018 |
| a Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during the period of naturally occurring cell death during development of the peripheral nervous system. | Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.
Wehner AB, Abdesselem H, Dickendesher TL, Imai F, Yoshida Y, Giger RJ, Pierchala BA., Free PMC Article | 09/23/2017 |
| Data suggest that voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic GluA2 localization and branch formation. | Voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic development.
Yamashita N, Aoki R, Chen S, Jitsuki-Takahashi A, Ohura S, Kamiya H, Goshima Y. | 12/17/2016 |
| Semaphorin 3A deficiency could improve hypoxia-induced myocardial injury via resisting inflammatory factors secretion, viability decline, cardiomyocyte apoptosis, reactive oxygen species release, ATP generation decline. | Semaphorin 3A deficiency improves hypoxia-induced myocardial injury via resisting inflammation and cardiomyocytes apoptosis.
Zhao C, Liu J, Zhang M, Wu Y. | 12/17/2016 |
| Upregulation of Sema3A increased cardiac electrical stability and reduced ventricular arrhythmias (VA). Sema3A silencing lead to sympathetic hyperinnervation, increased myocardial norepinephrine content and inducible VAs. | Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction.
Hu H, Xuan Y, Xue M, Cheng W, Wang Y, Li X, Yin J, Li X, Yang N, Shi Y, Yan S., Free PMC Article | 10/8/2016 |
| we show that SynIII phosphorylation at the CDK5 site is induced by activation of the semaphorin-3A (Sema3A) pathway, which is implicated in migration and orientation of cortical pyramidal neurons | Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo.
Perlini LE, Szczurkowska J, Ballif BA, Piccini A, Sacchetti S, Giovedì S, Benfenati F, Cancedda L., Free PMC Article | 01/16/2016 |
| Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections. | Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.
Wu KY, He M, Hou QQ, Sheng AL, Yuan L, Liu F, Liu WW, Li G, Jiang XY, Luo ZG., Free PMC Article | 05/16/2015 |
| Data suggest amechanism by which retrograde semaphorin 3A (Sema3A) signalling regulates the glutamate receptor localization through trafficking of cis-interacting PlexA4 with GluA2 along dendrites. | Plexin-A4-dependent retrograde semaphorin 3A signalling regulates the dendritic localization of GluA2-containing AMPA receptors.
Yamashita N, Usui H, Nakamura F, Chen S, Sasaki Y, Hida T, Suto F, Taniguchi M, Takei K, Goshima Y. | 12/6/2014 |
| This study delineate a Semaphorin-dependent signaling pathway that promotes dendritic complexity via the actin regulatory protein Farp1. | Activity-dependent regulation of dendritic complexity by semaphorin 3A through Farp1.
Cheadle L, Biederer T., Free PMC Article | 07/26/2014 |
| Overexpression of Sema3a in myocardial infarction border zone could reduce the inducibility of ventricular arrhythmias by reducing sympathetic hyper-reinnervation after infarction. | Overexpression of Sema3a in myocardial infarction border zone decreases vulnerability of ventricular tachycardia post-myocardial infarction in rats.
Chen RH, Li YG, Jiao KL, Zhang PP, Sun Y, Zhang LP, Fong XF, Li W, Yu Y., Free PMC Article | 01/11/2014 |