| Novel association between a transient receptor potential cation channel subfamily M member 5 expression quantitative trait locus rs35197079 and decreased susceptibility of gestational diabetes mellitus in a Chinese population. | Novel association between a transient receptor potential cation channel subfamily M member 5 expression quantitative trait locus rs35197079 and decreased susceptibility of gestational diabetes mellitus in a Chinese population.
Li X, Lai L, Su J, Chen S, Lin S, Wang B, Gao J, Zhang L, Yao K, Duan S., Free PMC Article | 02/5/2022 |
| Association of TRPM5 Asn235Ser Polymorphism and Trace Elements/Minerals in Chronic Gastritis Patients: a Case-Control Study. | Association of TRPM5 Asn235Ser Polymorphism and Trace Elements/Minerals in Chronic Gastritis Patients: a Case-Control Study.
Koc G, Soyocak A, Duzgun Ergun D, Pastaci Ozsobaci N, Andac-Ozturk S, Ergun S. | 01/15/2022 |
| Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance. | Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance.
Mardaryev A, van Lessen M, Alam M, Jimenez Acosta F, Bíró T, Paus R. | 12/18/2021 |
| TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes. | TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
Sakaguchi T, Okumura R, Ono C, Okuzaki D, Kawai T, Okochi Y, Tanimura N, Murakami M, Kayama H, Umemoto E, Kioka H, Ohtani T, Sakata Y, Miyake K, Okamura Y, Baba Y, Takeda K. | 05/22/2021 |
| genetic association studies in populations in Northern Europe, Maghreb, and Sri Lanka: Data suggest that SNPs in TAS2R50 (rs1376251), TRPM5 (rs800345), and TAS2R16 (rs860170) are associated with cultural food preferences; TAS2R16 (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TAS2R = taste receptor type 2) | A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Risso DS, Giuliani C, Antinucci M, Morini G, Garagnani P, Tofanelli S, Luiselli D. | 03/17/2018 |
| Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis | Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis.
Oztuzcu S, Onat AM, Pehlivan Y, Alibaz-Oner F, Donmez S, Cetin GY, Yolbas S, Bozgeyik I, Yilmaz N, Ozgen M, Cagatay Y, Kisacik B, Koca SS, Pamuk ON, Sayarlioglu M, Direskeneli H, Demiryurek AT. | 09/3/2016 |
| The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores | GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P., Free PMC Article | 02/6/2016 |
| In a Turkish population, genetic polymorphism in TRPM5 genes modify individual susceptibility to metabolic syndrome. | Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome.
Tabur S, Oztuzcu S, Duzen IV, Eraydin A, Eroglu S, Ozkaya M, Demiryürek AT. | 12/5/2015 |
| TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via an NCX to trigger MUC5AC secretion | TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.
Mitrovic S, Nogueira C, Cantero-Recasens G, Kiefer K, Fernández-Fernández JM, Popoff JF, Casano L, Bard FA, Gomez R, Valverde MA, Malhotra V., Free PMC Article | 04/25/2015 |
| TrpM5 expression was similar throughout the olfactory glomeruli. | Differential localization of NT-3 and TrpM5 in glomeruli of the olfactory bulb of mice.
Rolen SH, Salcedo E, Restrepo D, Finger TE., Free PMC Article | 12/20/2014 |
| The TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing primary open angle glaucoma in the Turkish population. | Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.
Okumus S, Demiryürek S, Gürler B, Coskun E, Bozgeyik I, Oztuzcu S, Kaydu E, Celik O, Erbagcı I, Demiryürek AT., Free PMC Article | 09/22/2014 |
| AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese. | A candidate gene study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in chinese hepatitis B patients.
Peng L, Guo J, Zhang Z, Liu L, Cao Y, Shi H, Wang J, Wang J, Friedman SL, Sninsky JJ., Free PMC Article | 03/22/2014 |
| extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition. | Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain.
Uchida K, Tominaga M., Free PMC Article | 02/8/2014 |
| common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus | Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.
Ketterer C, Müssig K, Heni M, Dudziak K, Randrianarisoa E, Wagner R, Machicao F, Stefan N, Holst JJ, Fritsche A, Häring HU, Staiger H. | 11/12/2011 |
| results suggest TRPM5 may play a role in upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands | Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line.
Buber MT, Cerne R, Cortés RY, Bryant RW, Lee SP. | 06/25/2011 |
| TRPM5 gene is imprinted, with preferential expression from the paternal allele. | Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.
Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B. | 10/27/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation between common variation in genes encoding sweet taste signaling components and human sucrose perception.
Fushan AA, Simons CT, Slack JP, Drayna D. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q. | 12/2/2009 |
| regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system | Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.
Liu D, Liman ER., Free PMC Article | 01/21/2010 |
| TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i | TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.
Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R., Free PMC Article | 01/21/2010 |
| understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations--{REVIEW} | TRPM5 and taste transduction.
Liman ER. | 01/21/2010 |
| data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms | Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains.
Liu D, Zhang Z, Liman ER. | 01/21/2010 |