| Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory perioddagger. | Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory period†.
Al-Alem L, Puttabyatappa M, Shrestha K, Choi Y, Rosewell K, Brännström M, Akin J, Jo M, Duffy DM, Curry TE., Free PMC Article | 01/8/2022 |
| Chronic high-fat diet consumption induces an alteration in plasma/brain neurotensin signaling, metabolic disturbance, systemic inflammation/oxidative stress, brain apoptosis, and dendritic spine loss. | Chronic high-fat diet consumption induces an alteration in plasma/brain neurotensin signaling, metabolic disturbance, systemic inflammation/oxidative stress, brain apoptosis, and dendritic spine loss.
Saiyasit N, Chunchai T, Apaijai N, Pratchayasakul W, Sripetchwandee J, Chattipakorn N, Chattipakorn SC. | 06/5/2021 |
| Results provide strong evidence that low endogenous levels of NTS in the pPVT contribute to an increased propensity toward excessive ethanol drinking. | Neurotensin in the posterior thalamic paraventricular nucleus: inhibitor of pharmacologically relevant ethanol drinking.
Pandey S, Badve PS, Curtis GR, Leibowitz SF, Barson JR., Free PMC Article | 04/4/2020 |
| Antipsychotic-induced dopamine supersensitivity enhances the ability of neurotensin in the nucleus accumbens to regulate dopamine-mediated behaviours, and this likely does not involve changes in local levels of NTS1 receptors or proneurotensin mRNA. Authors conclude that increasing neurotensin activity could be considered to attenuate antipsychotic-induced dopamine supersensitivity. | Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.
Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN. | 05/12/2018 |
| Results support the hypothesis that neurotensin is stimulating glutamate neurotransmission to initiate neural changes that sub-serve amphetamine sensitization and that glutamate is acting on NMDA receptors that are mostly likely composed of GluN2A, but not GluN2B, subunits. | Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.
Voyer D, Lévesque D, Rompré PP., Free PMC Article | 07/15/2017 |
| The present study revealed baseline regional differences in neurotensin-like immunoreactivity concentrations between the FSL and FRL rat strains and demonstrated that early maternal deprivation differentially affects the two strains. | Gene-environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions.
Ellenbroek BA, Angelucci F, Husum H, Mathé AA. | 02/18/2017 |
| This context-dependency was not found however for amphetamine-induced non-ambulatory and vertical activity suggesting that neurotensin can induce both a context-dependent and context-independent sensitization. | Role of context in neurotensin-induced sensitization to the locomotor stimulant effect of amphetamine.
Rouibi K, Rompré PP. | 04/4/2015 |
| neurotensin plays an important role in the regulation of spinal cardiovascular function, affecting both tone and adaptive reflexes | Intrathecal neurotensin is hypotensive, sympathoinhibitory and enhances the baroreflex in anaesthetized rat.
Zogovic B, Pilowsky PM., Free PMC Article | 08/11/2012 |
| Neurotensin plays a relevant role in the regulation of endogenous cortical glutamatergic transmission, especially by modulating the functional activity of cortical NMDA receptors. | Neurotensin regulates cortical glutamate transmission by modulating N-methyl-D-aspartate receptor functional activity: an in vivo microdialysis study.
Ferraro L, Beggiato S, Tomasini MC, Fuxe K, Tanganelli S, Antonelli T. | 06/9/2012 |
| PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin. | Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.
Jalkanen AJ, Savolainen K, Forsberg MM. | 06/9/2012 |
| regulates insulin secretion in pancreatic beta-cells | Neurotensin is a regulator of insulin secretion in pancreatic beta-cells.
Béraud-Dufour S, Abderrahmani A, Noel J, Brau F, Waeber G, Mazella J, Coppola T. | 03/12/2011 |
| suggesting a phosphodiesterase-3B-activation dependent induction of proopiomelanocortin and NT gene expression by leptin. | A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus.
Sahu A., Free PMC Article | 10/23/2010 |
| findings suggest that neurotensin promotes the dendrite outgrowth and the maturation of dendritic spines of cultured cortical neurons | Neurotensin promotes the dendrite elongation and the dendritic spine maturation of the cerebral cortex in vitro.
Gandou C, Ohtani A, Senzaki K, Shiga T. | 06/14/2010 |
| These results provide further support for the utility of the BRAT rat as a genetic animal model relevant to schizophrenia and drug discovery, and the potential of neurotensin agonists as treatments for cognitive deficits of schizophrenia. | The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog.
Feifel D, Mexal S, Melendez G, Liu PY, Goldenberg JR, Shilling PD., Free PMC Article | 01/21/2010 |
| Release of regulatory gut peptide neurotensin by acid and hyperosmolal solutions in the intestine in conscious rats. | Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats.
Rudholm T, Wallin B, Theodorsson E, Näslund E, Hellström PM. | 01/21/2010 |
| Administration of neurotensin into the substania nigra of the rat decrease passive defense reactions. | Serotoninergic mechanisms of the effects of neurotensin on passive avoidance behavior in rats.
Shugalev NP, Stavrovskaya AV, Ol'shanskii AS, Hartmann G, Lenard L. | 01/21/2010 |
| Electrophysiological results reinforce hypothesis that endogenous neurotensin neurotransmission differs in F344 and LEW rats. | Neurotensin modulation of spontaneous EPSCs in the nucleus accumbens of Lewis and Fischer 344 rats.
Yang SW, Rompré PP, Warren RA. | 01/21/2010 |
| Results demonstrate four distinct patterns of neurotensin response to methamphetamine self-administration in limbic and extrapyramidal regions. | Differential response of neurotensin to methamphetamine self-administration.
Frankel PS, Hoonakker AJ, Hanson GR. | 01/21/2010 |
| These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal. | Neurotensin protects pancreatic beta cells from apoptosis.
Coppola T, Béraud-Dufour S, Antoine A, Vincent JP, Mazella J. | 01/21/2010 |
| Neurotensin 1 is implicated in tonic pain. | Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model.
Roussy G, Dansereau MA, Doré-Savard L, Belleville K, Beaudet N, Richelson E, Sarret P. | 01/21/2010 |
| neurotensin promotes GABA release in the ventral pallidum and correspondingly inhibits cue-induced reinstatement | Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
Torregrossa MM, Kalivas PW., Free PMC Article | 01/21/2010 |
| Data support an effect of time of day and estrous cycle stage on prepulse inhibition (PPI) in female rats; diestrus and proestrus PPI are mediated in part by neurotensin. | Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats.
Kinkead B, Yan F, Owens MJ, Nemeroff CB., Free PMC Article | 01/21/2010 |
| data suggest that methionine enkephalin, neurotensin and somatostatin are released in the caudal trigeminal nucleus after electrical stimulation of the trigeminal ganglion, an experimental model of migraine | [Implication of the neuropeptides methionine enkephalin, neurotensin and somatostatin of the caudal trigeminal nucleus in the experimental migraine].
Samsam M, Coveñas R, Yajeya J, Ahangari R, Narváez JA, Montes-Gonzalo MC, González-Barón S. | 01/21/2010 |
| A lesion of the nigrostriatal pathway induced the expression of enkephalin, neurotensin, and substance P immunoreactivity in numerous pallidal cell bodies; each subgroup of neurones showed a different pattern of distribution | Enkephalin, neurotensin, and substance P immunoreactivite neurones of the rat GP following 6-hydroxydopamine lesion of the substantia nigra.
Martorana A, Fusco FR, D'Angelo V, Sancesario G, Bernardi G. | 01/21/2010 |
| Data show that although brain neuromedin N mRNA distribution largely overlaps in mice and rats, species differences exist in specific brain areas, and the distribution in mice resembles that of primates more than that of rats. | Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats.
Smits SM, Terwisscha van Scheltinga AF, van der Linden AJ, Burbach JP, Smidt MP. | 01/21/2010 |