| results provide the first structural evidence for the previously observed pH and voltage modulation of ZIP2-mediated metal transport, identify the substrate-binding site, and suggest a structure-based transport mechanism for the ZIP2 transporter. | Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2).
Gyimesi G, Albano G, Fuster DG, Hediger MA, Pujol-Giménez J., Free PMC Article | 12/14/2019 |
| Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. | Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2.
Franz MC, Pujol-Giménez J, Montalbetti N, Fernandez-Tenorio M, DeGrado TR, Niggli E, Romero MF, Hediger MA., Free PMC Article | 02/9/2019 |
| Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. | Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.
Pfaender S, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau S, Bockmann J, Huguet G, Bourgeron T, Boeckers TM, Grabrucker AM., Free PMC Article | 12/22/2018 |
| the splice switch to DeltaC-ZIP2 as well as decreased expression of other ZIPs caused zinc deficiency, which is sufficient for induction of MUC5AC. | Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.
Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T., Free PMC Article | 08/18/2018 |
| ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype | Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.
Giacconi R, Costarelli L, Malavolta M, Cardelli M, Galeazzi R, Piacenza F, Gasparini N, Basso A, Mariani E, Fulop T, Rink L, Dedoussis G, Herbein G, Jajte J, Provinciali M, Busco F, Mocchegiani E. | 10/22/2016 |
| results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes | ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.
Inoue Y, Hasegawa S, Ban S, Yamada T, Date Y, Mizutani H, Nakata S, Tanaka M, Hirashima N., Free PMC Article | 12/20/2014 |
| Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls. | Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature.
Sun P, Wang S, Jiang Y, Tao Y, Tian Y, Zhu K, Wan H, Zhang L, Zhang L. | 04/26/2014 |
| Increased expression of Zip2 gene is closely associated with immunity of pulmonary tuberculosis patients, suggesting that the Zip2 gene may play a key role in initial infection control. | Up-regulation of Slc39A2(Zip2) mRNA in peripheral blood mononuclear cells from patients with pulmonary tuberculosis.
Tao YT, Huang Q, Jiang YL, Wang XL, Sun P, Tian Y, Wu HL, Zhang M, Meng SB, Wang YS, Sun Q, Zhang LY. | 03/1/2014 |
| Expression of two Zn2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age. | ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.
Leung KW, Gvritishvili A, Liu Y, Tombran-Tink J. | 01/26/2013 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| regulation of ZIP2 protein in human breast cancer xenografts | Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.
Zhang LY, Wang XL, Sun DX, Liu XX, Hu XY, Kong F. | 01/21/2010 |
| Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease. | A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.
Giacconi R, Muti E, Malavolta M, Cardelli M, Pierpaoli S, Cipriano C, Costarelli L, Tesei S, Saba V, Mocchegiani E, Giacconi R, Muti E, Malavolta M, Cardelli M, Pierpaoli S, Cipriano C, Costarelli L, Tesei S, Saba V, Mocchegiani E. | 01/21/2010 |
| Gene expression regulation of ZIPs after zinc supplementation. | Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
Kahmann L, Uciechowski P, Warmuth S, Plümäkers B, Gressner AM, Malavolta M, Mocchegiani E, Rink L. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.
Giacconi R, Muti E, Malavolta M, Cardelli M, Pierpaoli S, Cipriano C, Costarelli L, Tesei S, Saba V, Mocchegiani E, Giacconi R, Muti E, Malavolta M, Cardelli M, Pierpaoli S, Cipriano C, Costarelli L, Tesei S, Saba V, Mocchegiani E. | 04/3/2008 |
| ZiP2 and Zip3 are down regulated in malignant cells | hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.
Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC., Free PMC Article | 01/21/2010 |