| TERT-independent telomere elongation and shelterin dysregulation after pulmonary exposure to stainless-steel welding fume in-vivo. | TERT-independent telomere elongation and shelterin dysregulation after pulmonary exposure to stainless-steel welding fume in-vivo.
Shoeb M, Meighan T, Kodali VK, Abadin H, Faroon O, Zarus GM, Erdely A, Antonini JM., Free PMC Article | 05/28/2024 |
| Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage. | Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage.
Li J, Feng Y, Zhao J, Fang Z, Liu H., Free PMC Article | 01/28/2023 |
| Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis. | Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis.
Festa Ortega JF, Heidor R, Auriemo AP, Marques Affonso J, Pereira D' Amico T, Herz C, de Conti A, Ract J, Gioieli LA, Purgatto E, Lamy E, P Pogribny I, Salvador Moreno F. | 12/25/2021 |
| Autophagy, TERT, and mitochondrial dysfunction in hyperoxia. | Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.
Beyer AM, Norwood Toro LE, Hughes WE, Young M, Clough AV, Gao F, Medhora M, Audi SH, Jacobs ER., Free PMC Article | 11/13/2021 |
| Reactive oxygen species up-regulation inhibits TERT expression, suppresses TERT activity and facilitates premature ovarian failure. | Protective effects ROS up-regulation on premature ovarian failure by suppressing ROS-TERT signal pathway.
Jiang HL, Cao LQ, Chen HY. | 12/14/2019 |
| Curcumin may be a good candidate to improve lifespan of rADSCs through promoting TERT gene expression. | Curcumin Affects Adipose Tissue-Derived Mesenchymal Stem Cell Aging Through TERT Gene Expression.
Pirmoradi S, Fathi E, Farahzadi R, Pilehvar-Soltanahmadi Y, Zarghami N. | 09/8/2018 |
| TERT was expressed in the basilar membranes during the first postnatal week. In vitro, TERT expression in progenitor cells reached a maximum at day 4 after culture and decreased as the culture time prolonged or the cell passage number increased. These results led us to hypothesize that TERT may be involved in the development of the cochlea and in maintaining the proliferation ability of progenitor cells. | Decreased expression of TERT correlated with postnatal cochlear development and proliferation reduction of cochlear progenitor cells.
Song YL, Tian KY, Mi WJ, Ding ZJ, Qiu Y, Chen FQ, Zha DJ, Qiu JH. | 09/1/2018 |
| Proliferation rate, telomerase activity, telomere length, and differentiation to cholinergic neuron-like cells (CNLCs) were observed to increase. Though, the expression level of telomerase reverse transcriptase gene increased, but CTC1 and TEN1 genes from Ctc1-Stn1-Ten1 complex encoding proteins with regulatory function significantly decreased | Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity.
Aminizadeh N, Tiraihi T, Mesbah-Namin SA, Taheri T. | 03/4/2017 |
| Histone deacetylase inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein abundance through enhanced degradation, which decreases telomerase activity and induces senescence. | Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.
Qing H, Aono J, Findeisen HM, Jones KL, Heywood EB, Bruemmer D. | 07/16/2016 |
| These findings suggest that cardiac telomerase activity may play an important role in the maintenance of normal cardiac function. | Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts.
Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Tsuchida K., Free PMC Article | 12/26/2015 |
| TERT is a genome-independent source of mature miRNA, and the changes in telomerase activity can significantly influence the level of miRNA in cardiomyocytes. | Silencing of TERT decreases levels of miR-1, miR-21, miR-29a and miR-208a in cardiomyocytes.
Drevytska TI, Nagibin VS, Gurianova VL, Kedlyan VR, Moibenko AA, Dosenko VE. | 07/25/2015 |
| Elevated Hcy but not hypertension was related to TERT DNA hypomethylation and reduced mRNA level, thus contributing to the shortening of LTL hypertension. | DNA methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in humans and in a rat model.
Zhang DH, Wen XM, Zhang L, Cui W. | 04/4/2015 |
| Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension. | Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Shen T, Ma J, Zhang L, Yu X, Liu M, Hou Y, Wang Y, Ma C, Li S, Zhu D., Free PMC Article | 10/11/2014 |
| These data suggest that TERT plays a neuroprotective role via anti-apoptosis in neurons after oxygen and glucose deprivation | The neuroprotective role and mechanisms of TERT in neurons with oxygen-glucose deprivation.
Li J, Qu Y, Chen D, Zhang L, Zhao F, Luo L, Pan L, Hua J, Mu D. | 06/14/2014 |
| hyperglycemia and hyperinsulinemia stimulate telomerase activity and the proliferation of vascular smooth muscle cells. | The effect of telomerase activity on vascular smooth muscle cell proliferation in type 2 diabetes in vivo and in vitro.
Sun X, Han F, Yi J, Hou N, Cao Z. | 11/16/2013 |
| DEHP and its metabolite MEHP can evidently induce spermatogenic injury in young male rats, which may be associated with their induction of increased TGF-beta1 expression and decreased telomerase activity in the rat testis. | [Di-2-ethylhexyl phthalate and its metabolite single-ethylhexyl phthalate affect TGF-beta 1 expression and telomerase activity in the testis of young male rats].
Ma H, Li J, Yang JJ, Tian WC, Liu H, Zhou YZ, Zhang WT, Zhao P. | 06/29/2013 |
| Cadmium may contribute to carcinogenesis by activating telomerase, and overexpressing the mRNAs of TERT, c-myc and p53, and causing apoptosis of normal hepatocytes. | Effects of cadmium on telomerase activity, expressions of TERT, c-myc and P53, and apoptosis of rat hepatocytes.
Dai W, Chen H, Yu R, He L, Chen B, Chen X. | 04/13/2013 |
| TERT might function as an anti-apoptotic protein by inhibiting activation of caspase-3. | The neuroprotective role of TERT via an antiapoptotic mechanism in neonatal rats after hypoxia-ischemia brain injury.
Zhao F, Qu Y, Xiong T, Duan Z, Ye Q, Mu D. | 02/9/2013 |
| Fluorine possibly damages the male reproductive system by reducing the expression of TERT and PCNA. | [Effect of fluoride on expression of telomerase reverse transcriptase expression and proliferating cell nuclear antigen in germ cells of rats' testes].
Jiang Q, Song XK, Cui QH, Chen LJ. | 10/27/2012 |
| Telomerase activation is present in ovary antral granulosa cells. | [The expression and control of telomerase in preantral ovary].
Zhang J, Zheng YH, Zheng LP. | 10/6/2012 |
| The expression of TERT significantly increases after electrical stimulation of the cerebellar fastigial nucleus. TERT may bind to Bax and inhibit Bax-mediated apoptosis. | [Effects of cerebellar fastigial nucleus electrical stimulation on telomerase reverse transcriptase expression and mitochondrial apoptotic pathway in rats with focal cerebral ischemia and reperfusion].
Yang Y, Liu JL, Qin C, Li JP, Wang XL, Zhang ZX, Zhang L. | 05/5/2012 |
| p53 and telomerase control rat myocardial tissue response to hypoxia and ageing | p53 and telomerase control rat myocardial tissue response to hypoxia and ageing.
Cataldi A, Zara S, Rapino M, Zingariello M, di Giacomo V, Antonucci A., Free PMC Article | 03/3/2012 |
| The expression levels of c-kit, pou5f1 and telomerase was significantly lower in the experimental group than those in the control group (P<0.05). | Decreased expression of c-kit and telomerase in a rat model of chronic endometrial ischemia.
Hu J, Yuan R., Free PMC Article | 07/16/2011 |
| A role is found for telomerase in early cell senescence of olfactory ensheathing glia and protection from oxidative damage. | Telomerase protects adult rodent olfactory ensheathing glia from early senescence.
Llamusà MB, Rubio MP, Ramón-Cueto A. | 07/2/2011 |
| TERT could be induced by hypoxia ischemia brain damage in neonatal rats, and might have a protective role in regulating cell apoptosis. | [Telomerase reverse transcriptase expression and cell apoptosis during hypoxia ischemia brain damage in neonatal rats].
Zhao F, Qu Y, Tang B, Mao M, Mu D. | 01/15/2011 |