| ATP6AP2 is robustly expressed in pancreatic beta cells and neuroendocrine tumors, and plays a role in maintaining cellular viability. | ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability.
Taguchi T, Kimura K, Suzuki A, Fujishima R, Shimizu N, Hoshiyama A, Masaki T, Inoue M, Kato Y, Satomi T, Takano K, Imada T, Sasaki S, Miyatsuka T., Free PMC Article | 06/15/2023 |
| Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease. | Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease.
Li J, Liang M, Zeng T, Qiu M, Zhang M, Jiang S, Tan L, Li A. | 03/19/2022 |
| The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule. | The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
Figueiredo M, Daryadel A, Sihn G, Müller DN, Popova E, Rouselle A, Nguyen G, Bader M, Wagner CA., Free PMC Article | 02/5/2022 |
| (Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR-YAP pathway. | (Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR-YAP pathway.
Yu S, Dong X, Yang M, Yu Q, Xiong J, Chen J, Dong B, Su Q., Free PMC Article | 11/13/2021 |
| Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis. | Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis.
Yildirim D, Bender O, Karagoz ZF, Helvacioglu F, Bilgic MA, Akcay A, Ruzgaresen NB. | 07/24/2021 |
| (Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway. | (Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Gao X, Zhang S, Wang D, Cheng Y, Jiang Y, Liu Y., Free PMC Article | 06/5/2021 |
| (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis. | (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/β-catenin pathways in glomerulonephritis.
Urushihara M, Kondo S, Kinoshita Y, Ozaki N, Jamba A, Nagai T, Fujioka K, Hattori T, Kagami S. | 11/28/2020 |
| COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats. | COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.
Wang F, Sun Y, Luo R, Lu X, Yang B, Yang T., Free PMC Article | 11/28/2020 |
| Atp6ap2 is critical for regulating the stored insulin pool and a balanced regulation of granule turnover is key to maintaining beta cell function and diabetes prevention | Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.
Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL., Free PMC Article | 04/11/2020 |
| PRR mediates myocardial injury, apoptosis, and the inflammatory response, likely through a PRR/extracellular signal-regulated kinase/reactive oxygen species pathway. | (Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy.
Dong X, Yu S, Wang Y, Yang M, Xiong J, Hei N, Dong B, Su Q, Chen J., Free PMC Article | 12/14/2019 |
| Activation of renal PRR and intrarenal renin angiotensin system occurs during albumin overload in rats. | Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.
Fang H, Deng M, Zhang L, Lu A, Su J, Xu C, Zhou L, Wang L, Ou JS, Wang W, Yang T., Free PMC Article | 09/21/2019 |
| Findings indicate that prorenin/renin receptor expression changes differently during pregnancy and preeclampsia in tissues related to cardiovascular functions and suggest a probable participation of the receptor during normal and preeclamptic pregnancy in the rat. | (Pro)renin/renin receptor expression during normal and preeclamptic pregnancy in rats.
Avila-Ramírez MA, Esteban-Martínez RL, López-Moctezuma E, Anguiano-Robledo L, Hernández-Campos ME, López-Sánchez P. | 01/12/2019 |
| From the data the authors assume that activation of (Pro) renin receptor (P)RR and V-ATPase may play an important role in tubulointerstitial fibrosis with possible involvement of interaction of V-ATPase B2 subunit and (P)RR. | Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis.
Liu Y, Zuo S, Li X, Fan J, Cao X, Yu X, Yang Q., Free PMC Article | 01/27/2018 |
| Renal PRR has a role in regulation of K(+) homeostasis through a local mechanism involving intrarenal renin-angiotensin-aldosterone system and coordinated regulation of membrane Na(+)- and K(+)-transporting proteins. | (Pro)Renin receptor regulates potassium homeostasis through a local mechanism.
Xu C, Lu A, Wang H, Fang H, Zhou L, Sun P, Yang T., Free PMC Article | 10/7/2017 |
| Prorenin receptor may be involved in the regulation of renal function and high salt-induced disorders. | Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron.
Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M. | 09/10/2016 |
| Soluble prorenin receptor via beta-catenin enhances urine concentration capability as a target of liver X receptor. | Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.
Lu X, Wang F, Xu C, Soodvilai S, Peng K, Su J, Zhao L, Yang KT, Feng Y, Zhou SF, Gustafsson JÅ, Yang T., Free PMC Article | 09/3/2016 |
| increased expression of placental (pro)renin receptor in pre-eclampsia rats. | Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia.
Thomason J, Reyes M, Allen SR, Jones RO, Beeram MR, Kuehl TJ, Suzuki F, Uddin MN. | 06/28/2016 |
| expressed in normal adrenal gland | Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism.
Recarti C, Seccia TM, Caroccia B, Gonzales-Campos A, Ceolotto G, Lenzini L, Petrelli L, Belloni AS, Rainey WE, Nussberger J, Rossi GP. | 04/16/2016 |
| These findings suggest that increased (P)RR plays a role in the development of ischemic acute kidney injury mediating possibly through activation of a renin-angiotensin system-independent pathway. | Role of intrarenal (pro)renin receptor in ischemic acute kidney injury in rats.
Ono M, Sakao Y, Tsuji T, Ohashi N, Yasuda H, Nishiyama A, Fujigaki Y, Kato A. | 02/27/2016 |
| Report that (pro)renin receptor blockade attenuates lipopolysaccharide-induced acute lung injury. | Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade.
Ishii K, Takeuchi H, Fukunaga K, Hirano Y, Suda K, Hagiwara T, Miyasho T, Yamada S, Nakamura R, Takahashi T, Wada N, Kawakubo H, Saikawa Y, Omori T, Betsuyaku T, Ichihara A, Kitagawa Y. | 01/16/2016 |
| during the early phase of ANG II-dependent hypertension, the increased (P)RR and COX-2 expression in the renal medulla may contribute to attenuate the vasoconstrictor effects of ANG II on renal hemodynamics | Renal medullary cyclooxygenase-2 and (pro)renin receptor expression during angiotensin II-dependent hypertension.
Gonzalez AA, Green T, Luffman C, Bourgeois CR, Gabriel Navar L, Prieto MC., Free PMC Article | 03/7/2015 |
| Pro)renin receptor and insulin resistance: possible roles of angiotensin II-dependent and -independent pathways. [review] | (Pro)renin receptor and insulin resistance: possible roles of angiotensin II-dependent and -independent pathways.
Rafiq K, Mori H, Masaki T, Nishiyama A. | 04/12/2014 |
| Prorenin receptor expressing cell density is stimulated by high-fat diet in visceral adipose tissue. | Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue.
Achard V, Tassistro V, Boullu-Ciocca S, Grino M. | 07/14/2012 |
| The (P)RR promoter is enriched with activating histone codes in the kidneys of spontaneously hypertensive rats. | Enrichment of (pro)renin receptor promoter with activating histone codes in the kidneys of spontaneously hypertensive rats.
Lee HA, Lee DY, Lee HJ, Han HS, Kim I. | 06/30/2012 |
| Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway. | Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
Huang J, Siragy HM., Free PMC Article | 04/21/2012 |