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    HCRT hypocretin neuropeptide precursor [ Homo sapiens (human) ]

    Gene ID: 3060, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease.

    Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease.
    Nigro E, D'Arco D, Moscatelli F, Pisani A, Amicone M, Riccio E, Capuano I, Argentino F, Monda M, Messina G, Daniele A, Polito R., Free PMC Article

    06/25/2024
    Bi-allelic variants in HCRT cause autosomal recessive narcolepsy.

    Bi-allelic variants in HCRT cause autosomal recessive narcolepsy.
    Hakami W, Thabet F, Alhashem A, Alghamdi A, Alshahwan S, Alkuraya FS, Tabarki B.

    06/3/2024
    Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion.

    Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion.
    Huan R, Zhang J, Yue J, Yang S, Han G, Cheng Y, Tan Y., Free PMC Article

    05/8/2024
    The role of orexin in fatigue and sleep quality in patients with primary Sjogren's syndrome.

    The role of orexin in fatigue and sleep quality in patients with primary Sjögren's syndrome.
    Sandikci SC, Gultuna S, Ozisler C, Aydin FN.

    02/22/2024
    Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.

    Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
    Guo X, Wen J, Gao Q, Zhao Y, Zhao Y, Wang C, Xu N, Shao Y, Chang X.

    11/16/2023
    Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells.

    Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells.
    Soejima Y, Iwata N, Nishioka R, Honda M, Nakano Y, Yamamoto K, Suyama A, Otsuka F., Free PMC Article

    08/30/2023
    Orexin pathway in Parkinson's disease: a review.

    Orexin pathway in Parkinson's disease: a review.
    Alrouji M, Al-Kuraishy HM, Al-Gareeb AI, Zaafar D, Batiha GE.

    06/26/2023
    Internal and external modulation factors of the orexin system (REVIEW).

    Internal and external modulation factors of the orexin system (REVIEW).
    Maruyama T, Ueta Y.

    06/2/2023
    Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.

    Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
    Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L., Free PMC Article

    05/12/2023
    Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction.

    Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction.
    Wohlfahrt P, Jenča D, Melenovský V, Jarolím P, Dlouhá D, Šramko M, Kotrč M, Želízko M, Mrázková J, Piťha J, Adámková V, Kautzner J., Free PMC Article

    03/26/2023
    How hypocretin agonists may improve the quality of wake in narcolepsy.

    How hypocretin agonists may improve the quality of wake in narcolepsy.
    Justinussen JL, Egebjerg C, Kornum BR.

    12/24/2022
    Differences in orexin-A level in the functional brain network of HUD patients undergoing harm reduction therapy.

    Differences in orexin-A level in the functional brain network of HUD patients undergoing harm reduction therapy.
    You WR, Lin LC, Lin WC, Tsai MC., Free PMC Article

    08/27/2022
    Comparison of orexin-A and neurofilament light chain levels in patients with relapsing-remitting multiple sclerosis: a pilot study.", trans "Orexin-A- es neurofilamentum-konnyulanc feherjeszintek relapszalo-remittalo sclerosis multiplexben szenvedoknel: pilot vizsgalat.

    Comparison of orexin-A and neurofilament light chain levels in patients with relapsing-remitting multiple sclerosis: a pilot study.
    Saruhan E, Korkmaz M, Altiparmak B, Tosun K, Kutlu G.

    08/13/2022
    Relation between orexin A and epileptic seizures.

    Relation between orexin A and epileptic seizures.
    Arslan GA, Saygi S, Bodur E, Cicek C, Tezer FI.

    07/16/2022
    Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.

    Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
    Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C.

    01/22/2022
    Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-kappaB and MAPK signaling pathways in cerebral ischemia/reperfusion injury.

    Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury.
    Xu D, Kong T, Shao Z, Liu M, Zhang R, Zhang S, Kong Q, Chen J, Cheng B, Wang C.

    01/1/2022
    Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.

    Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
    Goldstein N, Tsuneki H, Bhandarkar N, Aimaretti E, Haim Y, Kon K, Sato K, Wada T, Liberty IF, Kirshtein B, Dukhno O, Maixner N, Gepner Y, Sasaoka T, Rudich A.

    12/25/2021
    Sleep dysregulation in binge eating disorder and ""food addiction"": the orexin (hypocretin) system as a potential neurobiological link.

    Sleep dysregulation in binge eating disorder and "food addiction": the orexin (hypocretin) system as a potential neurobiological link.
    Mehr JB, Mitchison D, Bowrey HE, James MH., Free PMC Article

    12/4/2021
    [Orexin A as mediator in the gut-brain dialogue].", trans "Orexina A como mediadora en el dialogo intestino-cerebro.

    [Orexin A as mediator in the gut-brain dialogue].
    Mediavilla C.

    11/13/2021
    Significance of determining plasma orexin levels and analysis of related factors for the diagnosis of patients with narcolepsy.

    Significance of determining plasma orexin levels and analysis of related factors for the diagnosis of patients with narcolepsy.
    Zhu Y, He J, Shi J, Wang Y, Ma L, Gou H, Chen Y, Zhu Y.

    08/14/2021
    Alteration of orexin-A and PKCalpha in the postmortem brain of pure-opioid and multi-drug abusers.

    Alteration of orexin-A and PKCα in the postmortem brain of pure-opioid and multi-drug abusers.
    Sadat-Shirazi MS, Soltani H, Nikpour N, Haghshenas M, Khalifeh S, Mokri A, Zarrindast MR.

    07/17/2021
    Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.

    Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
    Hu S, Niu J, Zhang R, Li X, Luo M, Sang T, Guo J, Liu J, Ding X, Li X, Ma Y, Gao R.

    05/15/2021
    Increased plasma orexin-A concentrations are associated with the non-motor symptoms in Parkinson's disease patients.

    Increased plasma orexin-A concentrations are associated with the non-motor symptoms in Parkinson's disease patients.
    Huang S, Zhao Z, Ma J, Hu S, Li L, Wang Z, Sun W, Shi X, Li M, Zheng J.

    05/8/2021
    Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.

    Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
    Steward T, Mestre-Bach G, Granero R, Sánchez I, Riesco N, Vintró-Alcaraz C, Sauchelli S, Jiménez-Murcia S, Agüera Z, Fernández-García JC, Garrido-Sánchez L, Tinahones FJ, Casanueva FF, Baños RM, Botella C, Crujeiras AB, Torre R, Fernández-Real JM, Frühbeck G, Ortega FJ, Rodríguez A, Menchón JM, Fernández-Aranda F., Free PMC Article

    10/24/2020
    Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.

    Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.
    Kong T, Qiu K, Liu M, Cheng B, Pan Y, Yang C, Chen J, Wang C.

    08/22/2020
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