| Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development. | Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development.
Rjiba K, Mougou-Zerelli S, Hamida IH, Saad G, Khadija B, Jelloul A, Slimani W, Hasni Y, Dimassi S, Khelifa HB, Sallem A, Kammoun M, Abdallah HH, Gribaa M, Bignon-Topalovic J, Chelly S, Khairi H, Bibi M, Kacem M, Saad A, Bashamboo A, McElreavey K., Free PMC Article | 03/8/2023 |
| SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway. | SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway.
Du Z, Chen X, Zhu P, Sun W, Lv Q, Cheng S, Yang X, Yu X., Free PMC Article | 10/22/2022 |
| SOX8 promotes cetuximab resistance via HGF/MET bypass pathway activation in colorectal cancer. | SOX8 promotes cetuximab resistance via HGF/MET bypass pathway activation in colorectal cancer.
Piao HY, Qu JL, Liu YP. | 07/30/2022 |
| Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia. | Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia.
Wu S, Shao M, Zhang Y, Shi D. | 01/1/2022 |
| The oncogenic role of SOX8 in endometrial carcinoma. | The oncogenic role of SOX8 in endometrial carcinoma.
Tian W, Li Z, Bai L, Chen L, Yan Y, Li H, Han Y, Teng F, Gao C, Xue F, Wang Y., Free PMC Article | 10/16/2021 |
| Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells. | Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells.
Sun H, Wang H, Wang X, Aoki Y, Wang X, Yang Y, Cheng X, Wang Z, Wang X., Free PMC Article | 05/22/2021 |
| High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma. | High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma.
Chen S, Li H, Li X, Chen W, Zhang X, Yang Z, Chen Z, Chen J, Zhang Y, Shi D, Song M., Free PMC Article | 05/22/2021 |
| Low expression of CircRNA HIPK3 promotes osteoarthritis chondrocyte apoptosis by serving as a sponge of miR-124 to regulate SOX8. | Low expression of CircRNA HIPK3 promotes osteoarthritis chondrocyte apoptosis by serving as a sponge of miR-124 to regulate SOX8.
Wu Q, Yuan ZH, Ma XB, Tang XH. | 05/8/2021 |
| Variation analysis of SOX8 gene in Chinese men with non-obstructive azoospermia or oligozoospermia. | Variation analysis of SOX8 gene in Chinese men with non-obstructive azoospermia or oligozoospermia.
Zhang X, Ning Y, Liu W, Zhang T, Qin Y, Zhao S, Cao Y, Zhang H. | 01/16/2021 |
| High SOX8 expression is associated with progression of triple-negative breast cancer. | SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.
Tang H, Chen B, Liu P, Xie X, He R, Zhang L, Huang X, Xiao X, Xie X. | 05/30/2020 |
| These observations demonstrate that Sox8 is a novel player essential for the differentiation of M cells and antigen-specific IgA response in the gut. | Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.
Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K., Free PMC Article | 05/9/2020 |
| A transactivation domain in the middle of the proteins (TAM) synergizes with a C-terminal one (TAC). TAM comprises amphipathic alpha-helices predicted to form a protein-binding pocket and overlapping with minimal transactivation motifs (9-aa-TAD). One 9-aa-TAD sequence includes an evolutionarily conserved and functionally required EPhi[D/E]QYPhi motif. | The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism.
Haseeb A, Lefebvre V., Free PMC Article | 01/11/2020 |
| SOX8 is over-expressed in patients with high T stage, which affects the outcome of prognosis in CRC patients. High expression of SOX8 usually has a poor independent prognostic factor for CRC. | Over-expression of SOX8 predicts poor prognosis in colorectal cancer: A retrospective study.
Wang Y, Yang W, Liu T, Bai G, Liu M, Wang W., Free PMC Article | 07/13/2019 |
| These data demonstrate that SOX8 plays an important role in human reproduction and SOX8 mutations contribute to a spectrum of phenotypes including 46, XY DSD, male infertility and 46, XX POI. | Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies.
Portnoi MF, Dumargne MC, Rojo S, Witchel SF, Duncan AJ, Eozenou C, Bignon-Topalovic J, Yatsenko SA, Rajkovic A, Reyes-Mugica M, Almstrup K, Fusee L, Srivastava Y, Chantot-Bastaraud S, Hyon C, Louis-Sylvestre C, Validire P, de Malleray Pichard C, Ravel C, Christin-Maitre S, Brauner R, Rossetti R, Persani L, Charreau EH, Dain L, Chiauzzi VA, Mazen I, Rouba H, Schluth-Bolard C, MacGowan S, McLean WHI, Patin E, Rajpert-De Meyts E, Jauch R, Achermann JC, Siffroi JP, McElreavey K, Bashamboo A., Free PMC Article | 02/2/2019 |
| SOX8 bounds to the promoter region of FZD7 and induces the FZD7-mediated activation of the Wnt/beta-catenin pathway and confers chemoresistance and stemness properties and mediates epithelial mesenchymal transition in chemoresistant tongue squamous cell carcinoma. | SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway.
Xie SL, Fan S, Zhang SY, Chen WX, Li QX, Pan GK, Zhang HQ, Wang WW, Weng B, Zhang Z, Li JS, Lin ZY. | 10/13/2018 |
| Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8. | miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer.
Xie C, Han Y, Liu Y, Han L, Liu J., Free PMC Article | 07/25/2015 |
| SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. | Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells.
Herlofsen SR, Høiby T, Cacchiarelli D, Zhang X, Mikkelsen TS, Brinchmann JE. | 01/10/2015 |
| SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin levels in hepatocellular carcinoma | Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma.
Zhang S, Zhu C, Zhu L, Liu H, Liu S, Zhao N, Wu J, Huang X, Zhang Y, Jin J, Ji T, Ding X. | 10/25/2014 |
| The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis. | MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.
International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F., Free PMC Article | 08/10/2013 |
| SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful. | Differential expression of SOX2 and SOX17 in testicular germ cell tumors.
Nonaka D. | 01/21/2010 |
| Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut. | Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
Hoff S, Zeller F, von Weyhern CW, Wegner M, Schemann M, Michel K, Rühl A. | 01/21/2010 |