| The palmitoylation status of KChIP2 determines its subcellular distribution in cardiac myocytes. Stress promotes nuclear entry of KChIP2, diverting it from ion channel modulation at the plasma membrane to other functions in the nuclear compartment. | Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.
Murthy A, Workman SW, Jiang M, Hu J, Sifa I, Bernas T, Tang W, Deschenes I, Tseng GN., Free PMC Article | 07/18/2020 |
| polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca(2+) regulation of Kv4 channels | A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca(2+) regulation of Kv4 channels.
Murphy JG, Hoffman DA., Free PMC Article | 05/25/2019 |
| Binding of Ca(2+) to KChIP2 EF-hands can acutely modulate Kv4.3/KChIP2 channel inactivation gating. | Modulation of human Kv4.3/KChIP2 channel inactivation kinetics by cytoplasmic Ca(2).
Groen C, Bähring R. | 02/23/2019 |
| although there is a baseline presence of KChIP2 in the nucleus both in vivo and in vitro, KChIP2 does not directly regulate transcriptional activity. Moreover, the nuclear transport of KChIP2 is not dependent on Ca(2+). Thus, KChIP2 does not function as a conventional transcription factor in the heart. | Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling.
Winther SV, Tuomainen T, Borup R, Tavi P, Antoons G, Thomsen MB., Free PMC Article | 05/12/2018 |
| Our results do not support the notion that accessory KChIP2 binding is a prerequisite for dendritic trafficking and functional surface expression of Kv4.2 channels, however, accessory KChIP2 binding may play a potential role in Kv4.2 modulation during intrinsic plasticity processes. | Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons.
Prechtel H, Hartmann S, Minge D, Bähring R., Free PMC Article | 03/17/2018 |
| Results identify the KChIP2/miR-34 axis as a central regulator in developing cardiac electrical dysfunction. | KChIP2 is a core transcriptional regulator of cardiac excitability.
Nassal DM, Wan X, Liu H, Maleski D, Ramirez-Navarro A, Moravec CS, Ficker E, Laurita KR, Deschênes I., Free PMC Article | 11/18/2017 |
| A novel KCNQ1-G229D mutation identified in a juvenile-onset AF patient altered the IKs activity and kinetics, thereby increasing the arrhythmogenicity to AF. | A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.
Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M. | 04/30/2016 |
| mutations cause a gainoffunction of KV4.3/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation. | Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.
You T, Mao W, Cai B, Li F, Xu H., Free PMC Article | 03/26/2016 |
| The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Delta2-39. | The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Δ2-39.
Hovind LJ, Campbell DL., Free PMC Article | 10/29/2011 |
| KChIP2 differentially regulates total and cell surface Kv4.2 protein expression and Kv4 current densities. | Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.
Foeger NC, Marionneau C, Nerbonne JM., Free PMC Article | 11/27/2010 |
| The I(to) activator NS5806 modified Kv4.3/KChIP2 gating in several ways that inhibit current. | Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.
Lundby A, Jespersen T, Schmitt N, Grunnet M, Olesen SP, Cordeiro JM, Calloe K., Free PMC Article | 11/13/2010 |
| The cytoplasmic accessory subunit KChIP2 also assembles with Kv4.2 to increase peak current, shift V1/2 ~5mV, slow time to peak ~10%, slow inactivation ~100%, and speed recovery from inactivation ~250% without overshoot. | The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.
Levy DI, Cepaitis E, Wanderling S, Toth PT, Archer SL, Goldstein SA., Free PMC Article | 11/6/2010 |
| N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 channel/KCHIP2 complex activities. | Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.
Cotella D, Radicke S, Bortoluzzi A, Ravens U, Wettwer E, Santoro C, Sblattero D. | 08/30/2010 |
| Down-regulated atrial KChIP2 and Kv4.3 mRNA expressions in rheumatic heart disease patients with chronic atrial fibrillation might be one of the molecular bases responsible for the down-regulation of the I(to) current density of AF. | [Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation].
Tan XQ, Yang Y, Liu ZF, Bai ZR, Zhou W, Pei J, Chen GL, Zeng XR. | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| KChIP2c and KCNE2 simultaneously participate in recapitulation of the electrophysiological properties of transient outward current in cardiac myocytes | Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells.
Liu WJ, Wang HT, Chen WW, Deng JX, Jiang Y, Liu J. | 01/21/2010 |
| KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. | Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.
Jerng HH, Pfaffinger PJ., Free PMC Article | 01/21/2010 |
| These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. | Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells.
Venn N, Haynes LP, Burgoyne RD., Free PMC Article | 01/21/2010 |
| Regulation of Kv4.3 current by KChIP2 splice variants | Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?
Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF. | 01/21/2010 |
| KChIP-2 is a Ca2+-dependent repressor of the immune response. | Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.
Savignac M, Pintado B, Gutierrez-Adan A, Palczewska M, Mellström B, Naranjo JR., Free PMC Article | 01/21/2010 |
| Kv4.2 and K+ channel-interacting protein 2 make up a complex of Ito channels | Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.
Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. | 01/21/2010 |
| Data show that KChIP1, KChIP2.1, and KChIP2.2 could form homo- as well as hetero-oligomers, and that this oligomerization did not perturb their interaction with Kv4.2 potassium channel. | Protein-protein interactions of KChIP proteins and Kv4.2.
Lin YL, Chen CY, Cheng CP, Chang LS. | 01/21/2010 |
| Both Kv4.3 and KChIP2 may contribute to epicardial-endocardial gradients in the transient outward current in normal and failing hearts. | Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts.
Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A, Nattel S., Free PMC Article | 01/21/2010 |
| Analysis with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 protein | Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide.
Ren X, Shand SH, Takimoto K. | 01/21/2010 |
| the C-terminal domain of Kv4.2 plays a critical role in voltage-dependent activation and functional expression that is mediated by direct interaction between the Kv4.2 C terminus and KChIP2 | C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2.
Han W, Nattel S, Noguchi T, Shrier A. | 01/21/2010 |