| Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia | Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.
Reinstein E, Orvin K, Tayeb-Fligelman E, Stiebel-Kalish H, Tzur S, Pimienta AL, Bazak L, Bengal T, Cohen L, Gaton DD, Bormans C, Landau M, Kornowski R, Shohat M, Behar DM. | 12/19/2015 |
| ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells | Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.
Wang H, Han M, Whetsell W Jr, Wang J, Rich J, Hallahan D, Han Z., Free PMC Article | 05/10/2014 |
| this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. | New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).
Zencir S, Banerjee M, Dobson MJ, Ayaydin F, Fodor EA, Topcu Z, Mohanty S., Free PMC Article | 09/21/2013 |
| The study provided the first evidence showing that TIP-1 modulates p53 protein stability and is involved in the radioresistance of malignant gliomas. | Expression of TIP-1 confers radioresistance of malignant glioma cells.
Han M, Wang H, Zhang HT, Han Z., Free PMC Article | 03/2/2013 |
| The study reports the identification of 18 new glutaminase-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase-interacting protein partner proteins. | Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif.
Banerjee M, Zoetewey DL, Ovee M, Mazumder S, Petrenko VA, Samoylova TI, Mohanty S., Free PMC Article | 11/17/2012 |
| this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers. | The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.
Han M, Wang H, Zhang HT, Han Z., Free PMC Article | 08/18/2012 |
| HPV16 E6, Tip-1 and ARHGEF16 may cooperate to activate Cdc42 and support a potential link between the expression of HPV16 E6 and Cdc42 activation. | The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
Oliver AW, He X, Borthwick K, Donne AJ, Hampson L, Hampson IN., Free PMC Article | 11/18/2011 |
| This is the first study reporting BAI2 as an interaction partner of GIP. | Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.
Zencir S, Ovee M, Dobson MJ, Banerjee M, Topcu Z, Mohanty S., Free PMC Article | 10/15/2011 |
| TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3. | Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.
Yan X, Zhou H, Zhang J, Shi C, Xie X, Wu Y, Tian C, Shen Y, Long J. | 01/21/2010 |
| the overexpression, efficient refolding, single-step purification, and biophysical characterization of recombinant human TIP-1 with three different C-terminal target protein recognition sequence motifs by CD, fluorescence, and NMR methods | Probing the structure and function of human glutaminase-interacting protein: a possible target for drug design.
Banerjee M, Huang C, Marquez J, Mohanty S. | 01/21/2010 |
| HPV16 E6 protein may increase cell motility by augmenting GTP RhoA mediated activation of RhoA kinases and that this is dependent on the expression of the Tip-1 protein | The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein.
Hampson L, Li C, Oliver AW, Kitchener HC, Hampson IN. | 01/21/2010 |
| TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway | The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.
Kanamori M, Sandy P, Marzinotto S, Benetti R, Kai C, Hayashizaki Y, Schneider C, Suzuki H. | 01/21/2010 |
| TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand. | TIP-1 has PDZ scaffold antagonist activity.
Alewine C, Olsen O, Wade JB, Welling PA., Free PMC Article | 01/21/2010 |