| Liver specific disruption of Glutaredoxin 3 leads to iron accumulation and impaired cellular iron homeostasis. | Liver specific disruption of Glutaredoxin 3 leads to iron accumulation and impaired cellular iron homeostasis.
Cheng N, Donelson J, Breton G, Nakata PA. | 02/27/2023 |
| Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. | Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis.
Cheng N, Mo Q, Donelson J, Wang L, Breton G, Rodney GG, Wang J, Hirschi KD, Wehrens XHT, Nakata PA., Free PMC Article | 03/19/2022 |
| PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response. | PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response.
Pandya P, Braiman A, Isakov N. | 08/22/2020 |
| Grx3 CKO mice exhibited increase of ROS production, impaired Ca2+ handling, left ventricular hypertrophy and heart failure. | Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure.
Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N., Free PMC Article | 05/2/2020 |
| Grx3 is a key regulator of ROS in vivo and is involved in pregnancy-dependent mammary gland development and secretory activation through modulating cellular ROS. | Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N., Free PMC Article | 07/1/2017 |
| Data show that protein kinase C-interacting cousin of thioredoxin (PICOT) alleviates myocardial I/R injury by regulating intracellular reactive oxygen species (ROS) and free iron levels, and suggest that PICOT presents a therapeutic strategy for myocardial I/R injury. | PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species.
Kim J, Kim J, Kook H, Park WJ. | 06/24/2017 |
| investigation of role of Grx3: embryos absent Grx3 were small, morphological defects, early embryonic lethality; mRNA ubiquitously expressed in developing embryos, adult tissues; induced during oxidative stress; necessary for cell cycle progression | A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.
Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD., Free PMC Article | 09/10/2011 |
| These data suggest that AM and PICOT might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins. | PICOT is a molecule which binds to anamorsin.
Saito Y, Shibayama H, Tanaka H, Tanimura A, Matsumura I, Kanakura Y. | 07/30/2011 |
| Demonstrated a differential expression of PICOT in various cell types, with a predominant cytosolic staining of epithelial cells and low or undetectable levels of PICOT in the stroma. | Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium.
Ohayon A, Babichev Y, Galperin M, Altman A, Isakov N., Free PMC Article | 09/6/2010 |
| the precise PICOT protein level significantly affects the process of cardiac hypertrophy and cardiomyocyte contractility. | PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility.
Cha H, Kim JM, Oh JG, Jeong MH, Park CS, Park J, Jeong HJ, Park BK, Lee YH, Jeong D, Yang DK, Bernecker OY, Kim DH, Hajjar RJ, Park WJ., Free PMC Article | 01/21/2010 |
| PICOT regulated FcepsilonRI-mediated signals in RBL-2H3 cells and acted as a positive regulator on IL-4 and TNF-alpha expression, NFAT and degranulation and a negative regulator on a JNK signal pathway. | PICOT, protein kinase C theta-interacting protein, is a novel regulator of FcepsilonRI-mediated mast cell activation.
Kato N, Motohashi S, Okada T, Ozawa T, Mashima K. | 01/21/2010 |
| PICOT inhibits cardiac hypertrophy induced by pressure overload; overexpression increased ventricular function and cardiomyocyte contractility measured by ejection fraction & end-systolic pressure of transgenic hearts & peak shortening of cardiomyocytes | PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility.
Jeong D, Cha H, Kim E, Kang M, Yang DK, Kim JM, Yoon PO, Oh JG, Bernecker OY, Sakata S, Le TT, Cui L, Lee YH, Kim DH, Woo SH, Liao R, Hajjar RJ, Park WJ. | 01/21/2010 |