| Silencing UBE2K inhibits the growth of glioma cells by inducing the autophagy-related apoptosis. | Silencing UBE2K inhibits the growth of glioma cells by inducing the autophagy-related apoptosis.
Xin Z, Holgersson K, Zhu P, Tan H, Shi G, Szekely L, Wu T. | 07/29/2024 |
| Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology. | Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology.
Sahu M, Rani N, Kumar P. | 06/6/2024 |
| Hypoxia-induced UBE2K promotes the malignant progression of HCC. | Hypoxia-induced UBE2K promotes the malignant progression of HCC.
Ouyang G, Fu W, Guo J, Lu Q, Yao Y, Ge L, Zhao J, Zhang J, Hu X, Li S, Xu Q, Huang D, Zhang Y. | 05/19/2023 |
| UBE2K promotes the malignant progression of hepatocellular carcinoma by regulating c-Myc. | UBE2K promotes the malignant progression of hepatocellular carcinoma by regulating c-Myc.
Lei X, Hu X, Lu Q, Yao Y, Sun W, Ma Q, Huang D, Xu Q. | 01/7/2023 |
| The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. | The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Fatima A, Irmak D, Noormohammadi A, Rinschen MM, Das A, Leidecker O, Schindler C, Sánchez-Gaya V, Wagle P, Pokrzywa W, Hoppe T, Rada-Iglesias A, Vilchez D., Free PMC Article | 06/19/2021 |
| Expression of UBE2K's transcript has been shown to be dysregulated in the brain of individuals with a psychiatric illness and in the blood transcript expression was associated with positive symptom severity in schizophrenia. | Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.
Meiklejohn H, Mostaid MS, Luza S, Mancuso SG, Kang D, Atherton S, Rothmond DA, Weickert CS, Opazo CM, Pantelis C, Bush AI, Everall IP, Bousman CA. | 07/4/2020 |
| The data indicate that active site gate opening and closing rates for E2-25K are precisely balanced. | Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.
Rout MK, Lee BL, Lin A, Xiao W, Spyracopoulos L., Free PMC Article | 10/12/2019 |
| Crystal structure of the Ube2K/E2-25K and K48-linked diubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis. | Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Lee JG, Youn HS, Kang JY, Park SY, Kidera A, Yoo YJ, Eom SH. | 05/18/2019 |
| Hip2 works as a regulator in UV-induced cell cycle arrest and re-entry. | Hip2 ubiquitin-conjugating enzyme has a role in UV-induced G1/S arrest and re-entry.
Hong NH, Tak YJ, Rhim H, Kang S. | 04/6/2019 |
| The crystal structure of a Ube2K~ubiquitin conjugate has been described, and it was shown that even though it is monomeric, Ube2K can synthesize Lys48-linked ubiquitin chains. | The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.
Middleton AJ, Day CL., Free PMC Article | 09/24/2016 |
| Hip2, a ubiquitin-conjugating enzyme, can overcome radiation-induced G2/M cell cycle arrest and trigger the entry into mitosis. | Hip2 ubiquitin-conjugating enzyme overcomes radiation-induced G2/M arrest.
Bae Y, Jung SH, Kim GY, Rhim H, Kang S. | 03/1/2014 |
| An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K. | Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.
Helms KM, Wilson RC, Ogungbe IV, Setzer WN, Twigg PD. | 03/3/2012 |
| one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate. | The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.
Wilson RC, Edmondson SP, Flatt JW, Helms K, Twigg PD., Free PMC Article | 04/16/2011 |
| Results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death. | Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.
Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, Lee W., Free PMC Article | 02/26/2011 |
| This study suggests that Hip2 might be involved in the regulation of Smac-mediated apoptosis. | Hip2 interacts with and destabilizes Smac/DIABLO.
Bae Y, Kho CW, Lee SY, Rhim H, Kang S. | 08/23/2010 |
| Results suggest that in permeabilized, US11-expressing cells polyubiquitination of the MHC class I heavy chain substrate can be catalyzed by E2-25K. | E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.
Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V., Free PMC Article | 01/21/2010 |
| E2-25K is involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death. | Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
de Pril R, Fischer DF, Roos RA, van Leeuwen FW. | 01/21/2010 |