| HINT1 Gene Polymorphisms, Smoking Behaviour, and Personality Traits: A Haplotype Case-Control Study. | HINT1 Gene Polymorphisms, Smoking Behaviour, and Personality Traits: A Haplotype Case-Control Study.
Suchanecka A, Boroń A, Chmielowiec K, Strońska-Pluta A, Masiak J, Lachowicz M, Chmielowiec J, Trybek G, Grzywacz A., Free PMC Article | 07/29/2024 |
| The HINT1 Gene rs2526303 Polymorphism and Its Association with Personality Traits in Cigarette Smokers. | The HINT1 Gene rs2526303 Polymorphism and Its Association with Personality Traits in Cigarette Smokers.
Suchanecka A, Boroń A, Chmielowiec K, Strońska-Pluta A, Masiak J, Lachowicz M, Chmielowiec J, Janiszewska-Olszowska J, Grzywacz A., Free PMC Article | 01/30/2024 |
| Association of the rs3864283 Polymorphism Located in the HINT1 Gene with Cigarette Use and Personality Traits. | Association of the rs3864283 Polymorphism Located in the HINT1 Gene with Cigarette Use and Personality Traits.
Suchanecka A, Boroń A, Chmielowiec K, Strońska-Pluta A, Masiak J, Lachowicz M, Chmielowiec J, Grzywacz A., Free PMC Article | 08/28/2023 |
| HINT1 neuropathy in Lithuania: clinical, genetic, and functional profiling. | HINT1 neuropathy in Lithuania: clinical, genetic, and functional profiling.
Malcorps M, Amor-Barris S, Burnyte B, Vilimiene R, Armirola-Ricaurte C, Grigalioniene K, Ekshteyn A, Morkuniene A, Vaitkevicius A, De Vriendt E, Baets J, Scherer SS, Ambrozaityte L, Utkus A, Jordanova A, Peeters K., Free PMC Article | 10/22/2022 |
| HINT1-related neuropathy in Greek patients with Charcot-Marie-Tooth disease. | HINT1-related neuropathy in Greek patients with Charcot-Marie-Tooth disease.
Kontogeorgiou Z, Voudommatis C, Kartanou C, Pandis D, Breza M, Zambelis T, Stefanis L, Panas M, Koutsis G, Karadima G. | 05/7/2022 |
| HINT1 founder mutation causing axonal neuropathy with neuromyotonia in South America: A case report. | HINT1 founder mutation causing axonal neuropathy with neuromyotonia in South America: A case report.
de Aguiar Coelho Silva Madeiro B, Peeters K, Santos de Lima EL, Amor-Barris S, De Vriendt E, Jordanova A, Cartaxo Muniz MT, da Cunha Correia C., Free PMC Article | 03/26/2022 |
| Integrated analysis of ceRNA network reveals potential prognostic Hint1-related lncRNAs involved in hepatocellular carcinoma progression. | Integrated analysis of ceRNA network reveals potential prognostic Hint1-related lncRNAs involved in hepatocellular carcinoma progression.
Zhang C, Bao T, Ke Y, Liu X, Wang X, Liao W, He Y, Wang L., Free PMC Article | 03/12/2022 |
| Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5'-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells. | Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5'-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells.
Krakowiak A, Czernek L, Pichlak M, Kaczmarek R., Free PMC Article | 02/26/2022 |
| HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression. | HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y. | 01/8/2022 |
| Human HINT1 Mutant Proteins that Cause Axonal Motor Neuropathy Exhibit Anomalous Interactions with Partner Proteins. | Human HINT1 Mutant Proteins that Cause Axonal Motor Neuropathy Exhibit Anomalous Interactions with Partner Proteins.
Cortés-Montero E, Rodríguez-Muñoz M, Sánchez-Blázquez P, Garzón-Niño J. | 10/30/2021 |
| Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for beta-catenin or MITF in colon cancer and melanoma cells. | Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells.
Jung TY, Jin GR, Koo YB, Jang MM, Kim CW, Lee SY, Kim H, Lee CY, Lee SY, Ju BG, Kim HS., Free PMC Article | 08/14/2021 |
| HINT1 neuropathy in Norway: clinical, genetic and functional profiling. | HINT1 neuropathy in Norway: clinical, genetic and functional profiling.
Amor-Barris S, Høyer H, Brauteset LV, De Vriendt E, Strand L, Jordanova A, Braathen GJ, Peeters K., Free PMC Article | 07/3/2021 |
| Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A. | Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.
Strom A, Tong CL, Wagner CR. | 05/8/2021 |
| HINT1 gene pathogenic variants: the most common cause of recessive hereditary motor and sensory neuropathies in Russian patients. | HINT1 gene pathogenic variants: the most common cause of recessive hereditary motor and sensory neuropathies in Russian patients.
Shchagina OA, Milovidova TB, Murtazina AF, Rudenskaya GE, Nikitin SS, Dadali EL, Polyakov AV. | 10/10/2020 |
| The human HINT1 mutants reported to cause ARAN-NM all exhibited deficiencies in their sumoylase activity, thus suggesting a role for HINT1 isopeptidase activity in the pathogenesis of this human motor disease. | The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.
Cortés-Montero E, Rodríguez-Muñoz M, Sánchez-Blázquez P, Garzón J., Free PMC Article | 07/25/2020 |
| Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1), disrupts its interaction with the microphthalmia-associated transcription factor (MITF), and eventually activates the transcription of genes downstream of MITF in response to immunostimulation. | Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.
Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, Motzik A, Zheng M, Kang J, Zhong G, Liu C, Fang P, Guo M, Razin E, Wang J., Free PMC Article | 02/8/2020 |
| The c.335C>T (p.R119W) of the HINT1 gene probably underlies neuromyotonia and axonal neuropathy in this pedigree. | [Analysis of HINT1 gene variant in a case with neuromyotonia and axonal neuropathy].
Xu J, Yang Y, Liu Y. | 09/28/2019 |
| HINT1 mutations R37P, G93D and W123* destabilize the HINT1 dimer and significantly reduce catalytic activity and HINT1 inhibitor binding activity. The H112N mutant is dimeric and lacks catalytic activity, but has high affinity to AMP and a HINT1 inhibitor. Catalytic activity and dimeric structure of the surface mutants, C84R and G89V are similar to wild-type HINT1. | Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.
Shah RM, Maize KM, West HT, Strom AM, Finzel BC, Wagner CR. | 09/7/2019 |
| Two homozygous missense mutations in HINT1 gene were identified in two cases of axonal neuropathy with neuromyotonia. | Novel mutations in HINT1 gene cause the autosomal recessive axonal neuropathy with neuromyotonia.
Wang Z, Lin J, Qiao K, Cai S, Zhang VW, Zhao C, Lu J. | 03/9/2019 |
| the role of HINT1 neuropsychiatric disorders was summarized [review] | Emerging Roles of Histidine Triad Nucleotide Binding Protein 1 in Neuropsychiatric Diseases.
Dang YH, Liu ZW, Liu P, Wang JB. | 02/16/2019 |
| Thus, hHint1 appears to be structurally sensitive to irreversible inactivation by copper, which may be of neurotoxicological and pharmacological significance. | Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.
Shah R, Chou TF, Maize KM, Strom A, Finzel BC, Wagner CR. | 09/16/2017 |
| Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides). These results provide mechanistic insights underpinning histidine nucleophilic catalysis in general and human Hint1 catalysis, in particular, thus aiding the design of future proTides and the elucidation of the natural function of the Hint family of enzymes. | Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
Shah R, Maize KM, Zhou X, Finzel BC, Wagner CR. | 08/5/2017 |
| We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies--{REVIEW} | Axonal neuropathy with neuromyotonia: there is a HINT.
Peeters K, Chamova T, Tournev I, Jordanova A., Free PMC Article | 04/29/2017 |
| Underexpression of Hint1 is associated with invasion of hepatocellular carcinoma. | Hint1 suppresses migration and invasion of hepatocellular carcinoma cells in vitro by modulating girdin activity.
Wu XS, Bao TH, Ke Y, Sun DY, Shi ZT, Tang HR, Wang L. | 02/18/2017 |
| first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide | Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Dolot R, Kaczmarek R, Sęda A, Krakowiak A, Baraniak J, Nawrot B. | 12/17/2016 |