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    HLA-DMA major histocompatibility complex, class II, DM alpha [ Homo sapiens (human) ]

    Gene ID: 3108, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prognostic gene HLA-DMA associated with cell cycle and immune infiltrates in LUAD.

    Prognostic gene HLA-DMA associated with cell cycle and immune infiltrates in LUAD.
    Huang YJ, He JK, Duan X, Hou R, Shi J., Free PMC Article

    12/28/2023
    Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.

    Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.
    Liu D, Hofman P.

    06/25/2022
    Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM.

    Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM.
    Meurer T, Crivello P, Metzing M, Kester M, Megger DA, Chen W, van Veelen PA, van Balen P, Westendorf AM, Homa G, Layer SE, Turki AT, Griffioen M, Horn PA, Sitek B, Beelen DW, Falkenburg JHF, Arrieta-Bolaños E, Fleischhauer K.

    07/3/2021
    The ARL15 and HLA-DMA gene polymorphisms are associated with RA risk in Northwestern Han Chinese population.

    [Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].
    Wang J, Qi X, Zhang X, Yan W, You C.

    08/11/2018
    pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

    pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.
    Jiang W, Strohman MJ, Somasundaram S, Ayyangar S, Hou T, Wang N, Mellins ED., Free PMC Article

    09/24/2016
    study therefore reveals that HLA-DM polymorphic residues have a considerable impact on HLA-DM catalytic activity.

    HLA-DMA polymorphisms differentially affect MHC class II peptide loading.
    Álvaro-Benito M, Wieczorek M, Sticht J, Kipar C, Freund C.

    03/21/2015
    The structure of the HLA-DM-HLA-DR complex shows major rearrangements of the HLA-DR peptide-binding groove.

    Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.
    Pos W, Sethi DK, Call MJ, Schulze MS, Anders AK, Pyrdol J, Wucherpfennig KW., Free PMC Article

    03/2/2013
    DMA*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans

    Analysis of HLA-DM polymorphisms in the Chinese Han population.
    Feng ML, Liu RZ, Shen T, Zhao YL, Zhu ZY, Liu DZ.

    08/11/2012
    Multiple mechanisms, operating along the biosynthetic pathway of class II molecules, contribute to DM-mediated increases in the abundance of low-CLIP-affinity alleles.

    DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
    Rinderknecht CH, Roh S, Pashine A, Belmares MP, Patil NS, Lu N, Truong P, Hou T, Macaubas C, Yoon T, Wang N, Busch R, Mellins ED., Free PMC Article

    09/20/2010
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
    Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, Therwath A, Schächter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF, ANRS Genomic Group.

    02/11/2009
    Observational study of genotype prevalence. (HuGE Navigator)

    [HLA-DM polymorphisms in Guizhou Han individuals].
    Jiang HM, Wang YX, Wang Y.

    09/17/2008
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)See all PubMed (3) articles03/13/2008
    Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)

    Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese.
    Zhu X, Zhang Y, Wang Q, Wang F.

    03/13/2008
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (11) articles

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium.

    High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA.

    HLA-DM polymorphism and risk of trichloroethylene induced medicamentosa-like dermatitis.
    Yue F, Huang HL, Huang JX, Liang LY, Huang ZL, Wei QY, Chen XM.

    [HLA-DM gene polymorphism in Cantonese with condyloma acuminata].
    Yang WL, Yang J, Chen SQ, Xie FY, Huang XY, Ye T.

    [Relationship of trichloroethylene-induced medicamentosa like dermatitis to HLA-DMA and HLA-DMB].
    Yue F, Huang HL, Huang ZL, Li LY, Liang LY, Chen XM.

    Association of HLA-DM polymorphism with the production of antiphospholipid antibodies.
    Sanchez ML, Katsumata K, Atsumi T, Romero FI, Bertolaccini ML, Funke A, Amengual O, Kondeatis E, Vaughan RW, Cox A, Hughes GR, Khamashta MA.

    HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis.
    Morel J, Roch-Bras F, Molinari N, Sany J, Eliaou JF, Combe B.

    Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination.
    Dhiman N, Ovsyannikova IG, Pinsky NA, Vierkant RA, Jacobsen SJ, Jacobson RM, Poland GA.

    Association of TAP and HLA-DM genes with psoriasis in Koreans.
    Pyo CW, Hur SS, Kim YK, Kim TY, Kim TG.

    Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia.
    Bitti PP, Murgia BS, Ticca A, Ferrai R, Musu L, Piras ML, Puledda E, Campo S, Durando S, Montomoli C, Clayton DG, Mander AP, Bernardinelli L.

    03/13/2008
    HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.

    HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.
    Moxley G, Han J, Moxley G, Han J.

    01/21/2010
    HLA-DMA may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism.

    [Association of human leukocyte antigen non-classical genes with type 1 diabetes].
    Sang YM, Yan C, Zhu C, Ni GC, Hu YM.

    01/21/2010
    glycosylation promotes, but is not essential for, DMalphabeta ER exit; single DMalpha chains cannot fully oxidize without DMbeta, while DMbeta forms disulfide-linked homodimers without DMalpha

    The DMalpha and DMbeta chain cooperate in the oxidation and folding of HLA-DM.
    van Lith M, Benham AM.

    01/21/2010
    The results suggest that HLA-DMA*0104 may represent a novel allele of susceptibility to systemic lupus erythematosus.

    Polymorphism of HLA-DMA and DMB alleles in patients with systemic lupus erythematosus.
    Morel J, Simoes Cda S, Avinens O, Sany J, Combe B, Eliaou JF, Morel J, Simoes Cda S, Avinens O, Sany J, Combe B, Eliaou JF.

    01/21/2010
    The absence of HLA-DR/DM interactions at the limiting membrane prevents local loading of MHC class II molecules in phagosomes

    Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.
    Zwart W, Griekspoor A, Kuijl C, Marsman M, van Rheenen J, Janssen H, Calafat J, van Ham M, Janssen L, van Lith M, Jalink K, Neefjes J.

    01/21/2010
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