| Armadillo regulates nociceptive sensitivity in the absence of injury. | Armadillo regulates nociceptive sensitivity in the absence of injury.
Hale C, Moulton J, Otis Y, Ganter G., Free PMC Article | 06/14/2023 |
| Role of Armadillo repeat 2 and kinesin-II motor subunit Klp64D for wingless signaling in Drosophila. | Role of Armadillo repeat 2 and kinesin-II motor subunit Klp64D for wingless signaling in Drosophila.
Vuong LT, Won JH, Nguyen MB, Choi KW., Free PMC Article | 02/13/2021 |
| beta-Catenin is a pH sensor with decreased stability at higher intracellular pH. | β-Catenin is a pH sensor with decreased stability at higher intracellular pH.
White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL., Free PMC Article | 09/28/2019 |
| Study showed that the highly evolutionary conserved Y654 beta-cat-D665-E-cad major interaction site of the adherens junctions complex acts as primary mechanosensor. The site activates the beta-cat pathway through its mechanical opening in vivo that enables phosphorylation by Src42A kinase. | The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo.
Röper JC, Mitrossilis D, Stirnemann G, Waharte F, Brito I, Fernandez-Sanchez ME, Baaden M, Salamero J, Farge E., Free PMC Article | 11/24/2018 |
| Manipulating Axin or APC2 levels had no effect on beta-catenin destruction complex activity when Wnt signals were absent, but, surprisingly, had opposite effects on the destruction complex when Wnt signals were present. Elevating Axin made the complex more resistant to inactivation, while elevating APC2 levels enhanced inactivation. | Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo.
Schaefer KN, Bonello TT, Zhang S, Williams CE, Roberts DM, McKay DJ, Peifer M., Free PMC Article | 06/23/2018 |
| here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout beta-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts. | Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors.
Vishal K, Brooks DS, Bawa S, Gameros S, Stetsiv M, Geisbrecht ER., Free PMC Article | 07/15/2017 |
| An absolute requirement for Armadillo for activation and repression of Wingless protein target genes | Probing the canonicity of the Wnt/Wingless signaling pathway.
Franz A, Shlyueva D, Brunner E, Stark A, Basler K., Free PMC Article | 05/6/2017 |
| The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance | Arm-Gal4 inheritance influences development and lifespan in Drosophila melanogaster.
Slade FA, Staveley BE. | 09/24/2016 |
| dissociation of tyrosine-phosphorylated Arm from DE-cadherin allows dynamic actin to reorganize, leading to ring canal expansion and cell shape changes during the course of oogenesis | Btk29A-mediated tyrosine phosphorylation of armadillo/β-catenin promotes ring canal growth in Drosophila oogenesis.
Hamada-Kawaguchi N, Nishida Y, Yamamoto D., Free PMC Article | 02/27/2016 |
| Armless may promote Wg signaling by rescuing Armadillo from proteolytic degradation. | Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling.
Reim G, Hruzova M, Goetze S, Basler K., Free PMC Article | 12/26/2015 |
| Reduced Klp64D function is suppressed by activated Arm. | Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila.
Vuong LT, Mukhopadhyay B, Choi KW. | 10/18/2014 |
| Arm activity strongly suppresses supernumerary neuroblasts induced by overexpression of klu. | Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity.
Komori H, Xiao Q, McCartney BM, Lee CY., Free PMC Article | 03/15/2014 |
| Results implicate a previously unrecognized function for miR-310/13 in dampening the activity of Arm in early somatic and germline progenitor cells, whereby inappropriate/sustained activation of Arm-mediated signaling or cell adhesion may impact normal differentiation in the Drosophila male gonad. | The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis.
Pancratov R, Peng F, Smibert P, Yang S Jr, Olson ER, Guha-Gilford C, Kapoor AJ, Liang FX, Lai EC, Flaherty MS, DasgGupta R., Free PMC Article | 09/7/2013 |
| Arm is found at the plasma membrane of all epithelial cells, as part of the cadherincatenin complex | Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development.
Roberts DM, Pronobis MI, Alexandre KM, Rogers GC, Poulton JS, Schneider DE, Jung KC, McKay DJ, Peifer M., Free PMC Article | 08/4/2012 |
| Binding of Arm to DE-cadherin is weaker in polarizing cells than in polarized cells. | Differential regulation of adherens junction dynamics during apical-basal polarization.
Huang J, Huang L, Chen YJ, Austin E, Devor CE, Roegiers F, Hong Y., Free PMC Article | 04/21/2012 |
| Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. | Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin.
Xin N, Benchabane H, Tian A, Nguyen K, Klofas L, Ahmed Y., Free PMC Article | 12/24/2011 |
| Data show that Hipk dually regulates both Wingless and Hedgehog signaling by impeding the function of the E3 ubiquitin ligase complex, thereby inhibiting Armadillo ubiquitination and subsequent degradation. | Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling.
Swarup S, Verheyen EM., Free PMC Article | 10/1/2011 |
| In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. | Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila.
Muñoz-Descalzo S, Tkocz K, Balayo T, Arias AM., Free PMC Article | 05/28/2011 |
| the Hippo pathway restricts Wnt/beta-Catenin signaling by promoting an interaction between TAZ and DVL in the cytoplasm | The Hippo pathway regulates Wnt/beta-catenin signaling.
Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. | 05/10/2010 |
| Data show that in arm mutants, even a modest reduction in the basolateral component lgl leads to a full apical domain expansion or lgl phenotype. | Epithelial polarity: interactions between junctions and apical-basal machinery.
Kaplan NA, Liu X, Tolwinski NS., Free PMC Article | 04/19/2010 |
| proper polarity in the late embryo involves the asymmetric distribution and phosphorylation of Armadillo at the membrane, and interference with this Arm phosphorylation leads to polarity defects | Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo.
Colosimo PF, Tolwinski NS., Free PMC Article | 03/22/2010 |
| Data show that wingless (wg) represses transcription of the dpp gene in the ventral leg disc, and that this repression requires a tri-partite complex of the WG mediators armadillo and dTCF, and the co-repressor Brinker. | Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex.
Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, Srivastava GP, Iron D, Gaudenz K, Nie Q, Wan FY, Waterman ML, Marsh JL., Free PMC Article | 03/15/2010 |
| differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin. | In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin.
Kremer SA, Erdeniz N, Peterson-Nedry W, Swanson EA, Wehrli M., Free PMC Article | 01/21/2010 |
| Notch can promote the degradation of activated forms of Armadillo and may buffer cells against fluctuations in Wnt signalling activity. | Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila.
Sanders PG, Muñoz-Descalzo S, Balayo T, Wirtz-Peitz F, Hayward P, Arias AM., Free PMC Article | 01/21/2010 |
| Data have identified PR55 alpha as the regulatory subunit of PP2A that controls beta-catenin phosphorylation and degradation. PR55 alpha, but not the catalytic subunit, PP2Ac, directly interacts with beta-catenin. | PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.
Zhang W, Yang J, Liu Y, Chen X, Yu T, Jia J, Liu C., Free PMC Article | 01/21/2010 |