| Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. | Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.
Branciamore S, Gogoshin G, Rodin AS, Myers AJ., Free PMC Article | 07/10/2024 |
| Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population. | Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population.
Hong M, Jung J, Jin HS, Hwang D. | 08/27/2022 |
| HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. | HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC.
Mei J, Jiang G, Chen Y, Xu Y, Wan Y, Chen R, Liu F, Mao W, Zheng M, Xu J., Free PMC Article | 07/23/2022 |
| Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer. | Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.
Liu D, Hofman P. | 06/25/2022 |
| Identification of three novel HLA-DRA alleles by next-generation sequencing. | Identification of three novel HLA-DRA alleles by next-generation sequencing.
Suzuki S, Shigenari A, Ito S, Kulski JK, Shiina T. | 05/14/2022 |
| Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population. | Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population.
Nygård L, Laine AP, Kiviniemi M, Toppari J, Härkönen T, Knip M, Veijola R, Lempainen J, Ilonen J. | 03/19/2022 |
| Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection. | Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection.
Luo Y, Xue Y, Tang G, Lin Q, Song H, Liu W, Yin B, Huang J, Wei W, Mao L, Wang F, Sun Z., Free PMC Article | 02/19/2022 |
| The rs3129882/rs4248166 in HLA-DRA and rs34372695 in SYT11 are not associated with sporadic Parkinson's disease in Central Chinese population. | The rs3129882/rs4248166 in HLA-DRA and rs34372695 in SYT11 are not associated with sporadic Parkinson's disease in Central Chinese population.
Li J, Jian L, Huang J, Xiong N, Wang T. | 01/15/2022 |
| Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo. | Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.
Hoh BP, Zhang X, Deng L, Yuan K, Yew CW, Saw WY, Hoque MZ, Aghakhanian F, Phipps ME, Teo YY, Subbiah VK, Xu S., Free PMC Article | 10/9/2021 |
| Insights into the polymorphism in HLA-DRA and its evolutionary relationship with HLA haplotypes. | Insights into the polymorphism in HLA-DRA and its evolutionary relationship with HLA haplotypes.
Matern BM, Olieslagers TI, Voorter CEM, Groeneweg M, Tilanus MGJ. | 07/10/2021 |
| Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells. | Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells.
Perros AJ, Esguerra-Lallen A, Rooks K, Chong F, Engkilde-Pedersen S, Faddy HM, Hewlett E, Naidoo R, Tung JP, Fraser JF, Tesar P, Ziegenfuss M, Smith S, O'Brien D, Flower RL, Dean MM., Free PMC Article | 05/1/2021 |
| The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide. | The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide.
Salutari I, Martin R, Caflisch A. | 11/21/2020 |
| Loss of HLA-DR expression is associated with colorectal cancer development. | Characterising the prognostic potential of HLA-DR during colorectal cancer development.
Dunne MR, Phelan JJ, Michielsen AJ, Maguire AA, Dunne C, Martin P, Noonan S, Tosetto M, Geraghty R, Fennelly D, Sheahan K, Ryan EJ, O'Sullivan J., Free PMC Article | 07/25/2020 |
| Cd64 is up-regulated in neutrophils, but HLA-DR antigens are down-regulated in monocytes in septic shock patients. | A novel one-step extracellular staining for flow cytometry: Proof-of-concept on sepsis-related biomarkers.
Bourgoin P, Hayman J, Rimmelé T, Venet F, Malergue F, Monneret G. | 05/9/2020 |
| Identified an intergenic variant between HLADRA and HLA-DRB that is associated with Ulcerative Colitis prognosis, but not with susceptibility, and confirmed its clinical impact on 30-year outcomes. | An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis.
Lee HS, Yang SK, Hong M, Jung S, Kim BM, Moon JW, Park SH, Ye BD, Oh SH, Kim KM, Yoon YS, Yu CS, Baek J, Lee CH, Han B, Liu J, Haritunians T, McGovern DPB, Song K. | 04/11/2020 |
| We report that risk for type 1 diabetes in HLA-DR3 homozygotes is increased significantly by a previously unreported haplotype of three single nucleotide polymorphisms (SNPs) within the first intron of HLA-DRA1. | Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.
Aydemir Ö, Noble JA, Bailey JA, Lernmark Å, Marsh P, Andersson Svärd A, Bearoff F, Blankenhorn EP, Mordes JP, Better Diabetes Diagnosis (BDD) Study Group., Free PMC Article | 02/15/2020 |
| The dynamic changes in HLA-DRA expression in peripheral blood can accurately reflect the immune status of sepsis patients, and the reduction in HLA-DRA may be an important reason for the abnormal T cell differentiation. | Dynamic changes in human HLA-DRA gene expression and Th cell subsets in sepsis: Indications of immunosuppression and associated outcomes.
Xu J, Li J, Xiao K, Zou S, Yan P, Xie X, Xie L. | 01/18/2020 |
| This study demonstrated that only the non-suicidal depressed subgroup revealed significantly lower microglial reaction, i.e., a decreased density of HLA-DR positive microglia versus both depressed suicide victims and controls. | Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders.
Brisch R, Steiner J, Mawrin C, Krzyżanowska M, Jankowski Z, Gos T., Free PMC Article | 02/3/2018 |
| Low HLA-DRA expression is associated with sepsis. | Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
Winkler MS, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A., Free PMC Article | 10/7/2017 |
| In this prospective study we evaluated dynamic changes in monocyte HLA-DR expression during sepsis in relation to changes in HLA-DRA gene expression and Class II transactivator (CIITA), measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). | Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis.
Cajander S, Tina E, Bäckman A, Magnuson A, Strålin K, Söderquist B, Källman J., Free PMC Article | 07/22/2017 |
| Case-control study in Han Chinese from the southwest of the country suggests that risk of ALS is increased by the AA genotype at rs9268856 in the HLA-DRA/HLA-DRB5 gene, but not by the SNPs rs9268877 in HLA-DRA/HLA-DRB5, rs1980493 in BTNL2 or rs302668 in RAB38/CTSC | HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort.
Yang X, Zheng J, Tian S, Chen Y, An R, Zhao Q, Xu Y. | 06/3/2017 |
| Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins. | Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.
Sun Z, Jha HC, Pei YG, Robertson ES., Free PMC Article | 05/13/2017 |
| The frequency of CD14(+)HLA-DR-/low MDSCs could be considered as a poor prognostic predictor in small-cell lung cancer (SCLC) and the elimination of MDSCs during medical interventions may improve the prognosis of SCLC patients. | Increased circulating CD14(+)HLA-DR-/low myeloid-derived suppressor cells are associated with poor prognosis in patients with small-cell lung cancer.
Tian T, Gu X, Zhang B, Liu Y, Yuan C, Shao L, Guo Y, Fan K. | 07/2/2016 |
| This meta-analysis showed that the HLA-DRA rs3129882 A/G polymorphism was not a risk factor for Parkinson's disease in Chinese. | HLA-DRA rs3129882 A/G polymorphism was not a risk factor for Parkinson's disease in Chinese-based populations: a meta-analysis.
Ma ZG, Liu TW, Bo YL. | 03/5/2016 |
| CD14+HLA-DR(-/low) cells were significantly increased in gastric cancer tissue and were shown to have a critical role in CD4+T-cell immunosuppression. | Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer.
Li G, Wu K, Tao K, Lu X, Ma J, Mao Z, Li H, Shi L, Li J, Niu Y, Xiang F, Wang G. | 01/16/2016 |